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Cell contamination and branching process in random environment with immigration
Probability · Submitted 13 May 2008
abstract compiled · 2026-09-23 · no language-model review
The authors' main claim We determine the asymptotic behavior of the number of parasites in a cell line, which follows a branching process in random environment with state dependent immigration.
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The abstract, sentence by sentence
We consider a branching model for a population of dividing cells infected by parasites. Each cell receives parasites by inheritance from its mother cell and independent contamination from outside the population. Parasites multiply randomly inside the cell and are shared randomly between the two daughter cells when the cell divides. The law of the number of parasites which contaminate a given cell depends only on whether the cell is already infected or not. We determine the asymptotic behavior of the number of parasites in a cell line, which follows a branching process in random environment with state dependent immigration. We then derive a law of large numbers for the asymptotic proportions of cells with a given number of parasites. The main tools are branching processes in random environment and laws of large numbers for Markov tree.
background contribution method result interpretation main claim
| # | sentence | role | the authors' own work | states the main conclusion | strength |
|---|---|---|---|---|---|
| s0 | We consider a branching model for a population of dividing cells infected by parasites. | contribution 0.60 | 0.48 | 0.03 | asserted 0.88 |
| s1 | Each cell receives parasites by inheritance from its mother cell and independent contamination from outside the population. | method 0.93 | 0.13 | 0.02 | asserted 1.00 |
| s2 | Parasites multiply randomly inside the cell and are shared randomly between the two daughter cells when the cell divides. | method 0.94 | 0.16 | 0.03 | asserted 1.00 |
| s3 | The law of the number of parasites which contaminate a given cell depends only on whether the cell is already infected or not. | method 0.93 | 0.23 | 0.04 | asserted 1.00 |
| s4 | We determine the asymptotic behavior of the number of parasites in a cell line, which follows a branching process in random environment with state dependent immigration. | result 0.66 | 0.95 | 0.47 | asserted 1.00 |
| s5 | We then derive a law of large numbers for the asymptotic proportions of cells with a given number of parasites. | result 0.82 | 0.95 | 0.28 | asserted 1.00 |
| s6 | The main tools are branching processes in random environment and laws of large numbers for Markov tree. | method 1.00 | 0.34 | 0.03 | asserted 0.98 |
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Original abstract
We consider a branching model for a population of dividing cells infected by parasites. Each cell receives parasites by inheritance from its mother cell and independent contamination from outside the population. Parasites multiply randomly inside the cell and are shared randomly between the two daughter cells when the cell divides. The law of the number of parasites which contaminate a given cell depends only on whether the cell is already infected or not. We determine the asymptotic behavior of the number of parasites in a cell line, which follows a branching process in random environment with state dependent immigration. We then derive a law of large numbers for the asymptotic proportions of cells with a given number of parasites. The main tools are branching processes in random environment and laws of large numbers for Markov tree.
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Other models on cell lineage with differentiation have been investigated, see for example Bansaye [ref] on parasite infection and Evans and Steinsaltz [ref] on asymptotic models relying on super-Brownian motion.
Detection of cellular aging in a Galton-Watson process · Introduction · 0.99
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