Searching for New Physics with Charm

I provide a comprehensive review of indirect searches for New Physics with charmed mesons. I discuss current theoretical and experimental challenges and successes in understanding decays and mixings of those mesons. I argue that in many New Physics scenarios strong constraints, that surpass those from other search techniques, could be placed on the allowed model parameter space using the existent data from studies of charm transitions. This has direct implications for direct searches of physics beyond the Standard Model at the LHC.