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Randomization-Based Causal Inference from Unbalanced 2^2 Split-Plot Designs
Methodology · Submitted 11 Feb 2016
abstract compiled · 2026-09-23 · no language-model review
The authors' main claim Superiority over existing model-based alternatives is reported under a variety of settings for both binary and continuous outcomes.
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The abstract, sentence by sentence
Given two 2-level factors of interest, a 2^2 split-plot design} (a) takes each of the $2^2=4$ possible factorial combinations as a treatment, (b) identifies one factor as `whole-plot,' (c) divides the experimental units into blocks, and (d) assigns the treatments in such a way that all units within the same block receive the same level of the whole-plot factor. Assuming the potential outcomes framework, we propose in this paper a randomization-based estimation procedure for causal inference from 2^2 designs that are not necessarily balanced. Sampling variances of the point estimates are derived in closed form as linear combinations of the between- and within-block covariances of the potential outcomes. Results are compared to those under complete randomization as measures of design efficiency. Interval estimates are constructed based on conservative estimates of the sampling variances, and the frequency coverage properties evaluated via simulation. Asymptotic connections of the proposed approach to the model-based super-population inference are also established. Superiority over existing model-based alternatives is reported under a variety of settings for both binary and continuous outcomes.
background contribution method result interpretation main claim
| # | sentence | role | the authors' own work | states the main conclusion | strength |
|---|---|---|---|---|---|
| s0 | Given two 2-level factors of interest, a 2^2 split-plot design} (a) takes each of the $2^2=4$ possible factorial combinations as a treatment, (b) identifies one factor as `whole-plot,' (c) divides the experimental units into blocks, and (d) assigns the treatments in such a way that all units within the same block receive the same level of the whole-plot factor. | background 1.00 | 0.06 | 0.02 | asserted 0.99 |
| s1 | Assuming the potential outcomes framework, we propose in this paper a randomization-based estimation procedure for causal inference from 2^2 designs that are not necessarily balanced. | contribution 0.99 | 0.93 | 0.10 | asserted 0.98 |
| s2 | Sampling variances of the point estimates are derived in closed form as linear combinations of the between- and within-block covariances of the potential outcomes. | method 0.51 | 0.94 | 0.06 | asserted 1.00 |
| s3 | Results are compared to those under complete randomization as measures of design efficiency. | method 0.76 | 0.83 | 0.05 | asserted 0.87 |
| s4 | Interval estimates are constructed based on conservative estimates of the sampling variances, and the frequency coverage properties evaluated via simulation. | method 0.95 | 0.94 | 0.04 | asserted 0.97 |
| s5 | Asymptotic connections of the proposed approach to the model-based super-population inference are also established. | contribution 0.61 | 0.84 | 0.04 | asserted 1.00 |
| s6 | Superiority over existing model-based alternatives is reported under a variety of settings for both binary and continuous outcomes. | result 0.96 | 0.88 | 0.68 | asserted 1.00 |
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Original abstract
Given two 2-level factors of interest, a 2^2 split-plot design} (a) takes each of the $2^2=4$ possible factorial combinations as a treatment, (b) identifies one factor as `whole-plot,' (c) divides the experimental units into blocks, and (d) assigns the treatments in such a way that all units within the same block receive the same level of the whole-plot factor. Assuming the potential outcomes framework, we propose in this paper a randomization-based estimation procedure for causal inference from 2^2 designs that are not necessarily balanced. Sampling variances of the point estimates are derived in closed form as linear combinations of the between- and within-block covariances of the potential outcomes. Results are compared to those under complete randomization as measures of design efficiency. Interval estimates are constructed based on conservative estimates of the sampling variances, and the frequency coverage properties evaluated via simulation. Asymptotic connections of the proposed approach to the model-based super-population inference are also established. Superiority over existing model-based alternatives is reported under a variety of settings for both binary and continuous outcomes.
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