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Low-Dimensional Stochastic Modeling of the Electrical Properties of Biological Tissues
Computational Engineering, Finance, and Science · Submitted 22 Nov 2016
abstract compiled · 2026-09-23 · no language-model review
The authors' main claim It is shown how the number of parameters can be significantly reduced by the Karhunen-Loeve expansion.
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The abstract, sentence by sentence
Uncertainty quantification plays an important role in biomedical engineering as measurement data is often unavailable and literature data shows a wide variability. Using state-of-the-art methods one encounters difficulties when the number of random inputs is large. This is the case, e.g., when using composite Cole-Cole equations to model random electrical properties. It is shown how the number of parameters can be significantly reduced by the Karhunen-Loeve expansion. The low-dimensional random model is used to quantify uncertainties in the axon activation during deep brain stimulation. Numerical results for a Medtronic 3387 electrode design are given.
background contribution method result interpretation main claim
| # | sentence | role | the authors' own work | states the main conclusion | strength |
|---|---|---|---|---|---|
| s0 | Uncertainty quantification plays an important role in biomedical engineering as measurement data is often unavailable and literature data shows a wide variability. | background 1.00 | 0.06 | 0.03 | asserted 1.00 |
| s1 | Using state-of-the-art methods one encounters difficulties when the number of random inputs is large. | background 0.76 | 0.13 | 0.03 | asserted 0.98 |
| s2 | This is the case, e.g., when using composite Cole-Cole equations to model random electrical properties. | background 0.94 | 0.10 | 0.03 | asserted 0.82 |
| s3 | It is shown how the number of parameters can be significantly reduced by the Karhunen-Loeve expansion. | method 0.68 | 0.88 | 0.40 | asserted 1.00 |
| s4 | The low-dimensional random model is used to quantify uncertainties in the axon activation during deep brain stimulation. | contribution 0.67 | 0.90 | 0.33 | asserted 1.00 |
| s5 | Numerical results for a Medtronic 3387 electrode design are given. | result 0.78 | 0.88 | 0.07 | asserted 0.98 |
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The paper
Original abstract
Uncertainty quantification plays an important role in biomedical engineering as measurement data is often unavailable and literature data shows a wide variability. Using state-of-the-art methods one encounters difficulties when the number of random inputs is large. This is the case, e.g., when using composite Cole-Cole equations to model random electrical properties. It is shown how the number of parameters can be significantly reduced by the Karhunen-Loeve expansion. The low-dimensional random model is used to quantify uncertainties in the axon activation during deep brain stimulation. Numerical results for a Medtronic 3387 electrode design are given.
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