RECORD
A UV-cured nanofibrous membrane of vinylbenzylated gelatin-poly({\epsilon}-caprolactone) dimethacrylate co-network by scalable free surface electrospinning
Applied Physics · Submitted 27 May 2018
abstract compiled · 2026-09-23 · no language-model review
The authors' main claim These results therefore support the use of PCL DMA as hydrophobic, biodegradable crosslinker and provide new insight on the scalable design of water insoluble, mechanical competent gelatin membranes for healthcare applications.
The compiled record
The paper's own sentences, arranged. Each label is drawn from a closed vocabulary; the number beside it is the probability the classifier gave that label. Numbers in the tables are the authors', checked by code. No sentence in this record was written by a model.
Open the compiled record
The abstract, sentence by sentence
Electrospun nanofibrous membranes of natural polymers, such as gelatin, are fundamental in the design of regenerative devices. Crosslinking of electrospun fibres from gelatin is required to prevent dissolution in water, to retain the original nanofibre morphology after immersion in water, and to improve the thermal and mechanical properties, although this is still challenging to accomplish in a controlled fashion. In this study, we have investigated the scalable manufacture and structural stability in aqueous environment of a UV-cured nanofibrous membrane fabricated by free surface electrospinning (FSES) of aqueous solutions containing vinylbenzylated gelatin and poly(epsilon-caprolactone) dimethacrylate (PCL-DMA). Vinylbenzylated gelatin was obtained via chemical functionalisation with photopolymerisable 4-vinylbenzyl chloride (4VBC) groups, so that the gelatin and PCL phase in electrospun fibres were integrated in a covalent UV-cured co-network at the molecular scale, rather than being simply physically mixed. UV-cured nanofibrous membranes did not dissolve in water and showed enhanced thermal and mechanical properties, with respect to as-spun samples, indicating the effectiveness of the photo-crosslinking reaction. In addition, UV-cured gelatin/PCL membranes displayed increased structural stability in water with respect to PCL-free samples and were highly tolerated by G292 osteosarcoma cells. These results therefore support the use of PCL DMA as hydrophobic, biodegradable crosslinker and provide new insight on the scalable design of water insoluble, mechanical competent gelatin membranes for healthcare applications.
background contribution method result interpretation main claim
| # | sentence | role | the authors' own work | states the main conclusion | strength |
|---|---|---|---|---|---|
| s0 | Electrospun nanofibrous membranes of natural polymers, such as gelatin, are fundamental in the design of regenerative devices. | background 1.00 | 0.05 | 0.02 | asserted 1.00 |
| s1 | Crosslinking of electrospun fibres from gelatin is required to prevent dissolution in water, to retain the original nanofibre morphology after immersion in water, and to improve the thermal and mechanical properties, although this is still challenging to accomplish in a controlled fashion. | background 0.73 | 0.06 | 0.03 | asserted 1.00 |
| s2 | In this study, we have investigated the scalable manufacture and structural stability in aqueous environment of a UV-cured nanofibrous membrane fabricated by free surface electrospinning (FSES) of aqueous solutions containing vinylbenzylated gelatin and poly(epsilon-caprolactone) dimethacrylate (PCL-DMA). | contribution 0.98 | 0.95 | 0.07 | asserted 0.88 |
| s3 | Vinylbenzylated gelatin was obtained via chemical functionalisation with photopolymerisable 4-vinylbenzyl chloride (4VBC) groups, so that the gelatin and PCL phase in electrospun fibres were integrated in a covalent UV-cured co-network at the molecular scale, rather than being simply physically mixed. | method 0.87 | 0.90 | 0.06 | asserted 1.00 |
| s4 | UV-cured nanofibrous membranes did not dissolve in water and showed enhanced thermal and mechanical properties, with respect to as-spun samples, indicating the effectiveness of the photo-crosslinking reaction. | result 0.99 | 0.96 | 0.20 | asserted 0.88 |
| s5 | In addition, UV-cured gelatin/PCL membranes displayed increased structural stability in water with respect to PCL-free samples and were highly tolerated by G292 osteosarcoma cells. | result 1.00 | 0.94 | 0.16 | asserted 1.00 |
| s6 | These results therefore support the use of PCL DMA as hydrophobic, biodegradable crosslinker and provide new insight on the scalable design of water insoluble, mechanical competent gelatin membranes for healthcare applications. | interpretation 1.00 | 0.72 | 0.88 | hedged possibility 0.51 |
What was examined, and what was not
- arXiv listing abstract v2
- full text
- figures and tables
- references and citing sentences
- relations to other papers
- P abstract
- S sections
- T body sentences
- C citations
- R cross-paper relations
The paper
Original abstract
Electrospun nanofibrous membranes of natural polymers, such as gelatin, are fundamental in the design of regenerative devices. Crosslinking of electrospun fibres from gelatin is required to prevent dissolution in water, to retain the original nanofibre morphology after immersion in water, and to improve the thermal and mechanical properties, although this is still challenging to accomplish in a controlled fashion. In this study, we have investigated the scalable manufacture and structural stability in aqueous environment of a UV-cured nanofibrous membrane fabricated by free surface electrospinning (FSES) of aqueous solutions containing vinylbenzylated gelatin and poly(epsilon-caprolactone) dimethacrylate (PCL-DMA). Vinylbenzylated gelatin was obtained via chemical functionalisation with photopolymerisable 4-vinylbenzyl chloride (4VBC) groups, so that the gelatin and PCL phase in electrospun fibres were integrated in a covalent UV-cured co-network at the molecular scale, rather than being simply physically mixed. UV-cured nanofibrous membranes did not dissolve in water and showed enhanced thermal and mechanical properties, with respect to as-spun samples, indicating the effectiveness of the photo-crosslinking reaction. In addition, UV-cured gelatin/PCL membranes displayed increased structural stability in water with respect to PCL-free samples and were highly tolerated by G292 osteosarcoma cells. These results therefore support the use of PCL DMA as hydrophobic, biodegradable crosslinker and provide new insight on the scalable design of water insoluble, mechanical competent gelatin membranes for healthcare applications.
Human review
Discussion
Know something about this paper? Leave a comment, or highlight any passage above to comment on it.