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Automated inference of production rules for glycans
Logic in Computer Science · Submitted 5 Jul 2021
abstract compiled · 2026-09-23 · no language-model review
The authors' main claim In this paper, we present the first SMT-solver-based iterative method that infers the assembly process of the glycans by analyzing the set of glycans from a cell.
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The abstract, sentence by sentence
Glycans are tree-like polymers made up of sugar monomer building blocks. They are found on the surface of all living cells, and distinct glycan trees act as identity markers for distinct cell types. Proteins called GTase enzymes assemble glycans via the successive addition of monomer building blocks. The rules by which the enzymes operate are not fully understood. In this paper, we present the first SMT-solver-based iterative method that infers the assembly process of the glycans by analyzing the set of glycans from a cell. We have built a tool based on the method and applied it to infer rules based on published glycan data.
background contribution method result interpretation main claim
| # | sentence | role | the authors' own work | states the main conclusion | strength |
|---|---|---|---|---|---|
| s0 | Glycans are tree-like polymers made up of sugar monomer building blocks. | background 1.00 | 0.04 | 0.02 | asserted 1.00 |
| s1 | They are found on the surface of all living cells, and distinct glycan trees act as identity markers for distinct cell types. | background 1.00 | 0.04 | 0.02 | asserted 1.00 |
| s2 | Proteins called GTase enzymes assemble glycans via the successive addition of monomer building blocks. | background 1.00 | 0.04 | 0.02 | asserted 1.00 |
| s3 | The rules by which the enzymes operate are not fully understood. | gap 0.97 | 0.04 | 0.02 | asserted 0.99 |
| s4 | In this paper, we present the first SMT-solver-based iterative method that infers the assembly process of the glycans by analyzing the set of glycans from a cell. | contribution 0.88 | 0.96 | 0.57 | asserted 1.00 |
| s5 | We have built a tool based on the method and applied it to infer rules based on published glycan data. | contribution 0.66 | 0.96 | 0.20 | asserted 1.00 |
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The paper
Original abstract
Glycans are tree-like polymers made up of sugar monomer building blocks. They are found on the surface of all living cells, and distinct glycan trees act as identity markers for distinct cell types. Proteins called GTase enzymes assemble glycans via the successive addition of monomer building blocks. The rules by which the enzymes operate are not fully understood. In this paper, we present the first SMT-solver-based iterative method that infers the assembly process of the glycans by analyzing the set of glycans from a cell. We have built a tool based on the method and applied it to infer rules based on published glycan data.
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