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Carbon nanotube substrates enhance SARS-CoV-2 spike protein ion yields in matrix assisted laser desorption-ionization mass spectrometry

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arxiv 2210.04853 v1 pith:DLRSIS4E submitted 2022-10-10 physics.bio-ph physics.app-ph

T. Schenkel , A. M. Snijders , K. Nakamura , P.A. Seidl , B. Mak , L. Obst-Huebl , H. Knobel , I. Pong
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A. Persaud J. van Tilborg T. Ostermayr S. Steinke E. A. Blakely Q. Ji A. Javey R. Kapadia C.G.R. Geddes E. Esarey
This is my paper · ORCID
classification physics.bio-phphysics.app-ph
keywords masssubstratesyieldsproteinsars-cov-2spectrometryspikeassisted
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Nanostructured surfaces enhance ion yields in matrix assisted laser desorption-ionization mass spectrometry (MALDI-MS). The spike protein complex, S1, is one fingerprint signature of Sars-CoV-2 with a mass of 75 kDa. Here, we show that MALDI-MS yields of Sars-CoV-2 spike protein ions in the 100 kDa range are enhanced 50-fold when the matrix-analyte solution is placed on substrates that are coated with a dense forest of multi-walled carbon nanotubes, compared to yields from uncoated substrates. Nanostructured substrates can support the development of mass spectrometry techniques for sensitive pathogen detection and environmental monitoring.

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