RECORD
Quantitative pulsatility measurements using 3D Dynamic Ultrasound Localization Microscopy
Medical Physics · Submitted 25 Mar 2023
abstract compiled · 2026-09-23 · no language-model review
The authors' main claim Our study provides the first step towards a new biomarker that would allow the detection of dynamic abnormalities in microvessels in the whole brain volume, which could be linked to early signs of neurodegenerative diseases.
The compiled record
The paper's own sentences, arranged. Each label is drawn from a closed vocabulary; the number beside it is the probability the classifier gave that label. Numbers in the tables are the authors', checked by code. No sentence in this record was written by a model.
Open the compiled record
The abstract, sentence by sentence
A rise in blood flow velocity variations (i.e., pulsatility) in the brain, caused by the stiffening of upstream arteries, is associated with cognitive impairment and neurodegenerative diseases. The study of this phenomenon requires brain-wide pulsatility measurements, with high penetration depth and high spatiotemporal resolution. The development of Dynamic Ultrasound Localization Microscopy (DULM), based on ULM, has enabled pulsatility measurements in the rodent brain in 2D. However, 2D imaging accesses only one slice of the brain and measures biased velocities due to 2D projection. Herein, we present 3D DULM, which can extract quantitative pulsatility measurements in the cat brain with craniotomy and in the whole mouse brain through the skull, showing a wide range of flow hemodynamics in both large and small vessels. We highlighted a decrease in pulsatility along the vascular tree in the cat brain, and performed an intra-animal validation of the method by showing consistent measurements between the two sides of the Willis circle in the mouse brain. Our study provides the first step towards a new biomarker that would allow the detection of dynamic abnormalities in microvessels in the whole brain volume, which could be linked to early signs of neurodegenerative diseases.
background contribution method result interpretation main claim
| # | sentence | role | the authors' own work | states the main conclusion | strength |
|---|---|---|---|---|---|
| s0 | A rise in blood flow velocity variations (i.e., pulsatility) in the brain, caused by the stiffening of upstream arteries, is associated with cognitive impairment and neurodegenerative diseases. | background 1.00 | 0.05 | 0.05 | asserted 1.00 |
| s1 | The study of this phenomenon requires brain-wide pulsatility measurements, with high penetration depth and high spatiotemporal resolution. | background 0.66 | 0.05 | 0.03 | asserted 0.99 |
| s2 | The development of Dynamic Ultrasound Localization Microscopy (DULM), based on ULM, has enabled pulsatility measurements in the rodent brain in 2D. | background 0.96 | 0.21 | 0.03 | asserted 1.00 |
| s3 | However, 2D imaging accesses only one slice of the brain and measures biased velocities due to 2D projection. | gap 0.90 | 0.10 | 0.03 | asserted 1.00 |
| s4 | Herein, we present 3D DULM, which can extract quantitative pulsatility measurements in the cat brain with craniotomy and in the whole mouse brain through the skull, showing a wide range of flow hemodynamics in both large and small vessels. | contribution 0.98 | 0.96 | 0.35 | asserted 1.00 |
| s5 | We highlighted a decrease in pulsatility along the vascular tree in the cat brain, and performed an intra-animal validation of the method by showing consistent measurements between the two sides of the Willis circle in the mouse brain. | result 0.99 | 0.98 | 0.17 | asserted 1.00 |
| s6 | Our study provides the first step towards a new biomarker that would allow the detection of dynamic abnormalities in microvessels in the whole brain volume, which could be linked to early signs of neurodegenerative diseases. | interpretation 0.65 | 0.43 | 0.71 | hedged possibility 0.93 |
What was examined, and what was not
- arXiv listing abstract v1
- full text
- figures and tables
- references and citing sentences
- relations to other papers
- P abstract
- S sections
- T body sentences
- C citations
- R cross-paper relations
The paper
Original abstract
A rise in blood flow velocity variations (i.e., pulsatility) in the brain, caused by the stiffening of upstream arteries, is associated with cognitive impairment and neurodegenerative diseases. The study of this phenomenon requires brain-wide pulsatility measurements, with high penetration depth and high spatiotemporal resolution. The development of Dynamic Ultrasound Localization Microscopy (DULM), based on ULM, has enabled pulsatility measurements in the rodent brain in 2D. However, 2D imaging accesses only one slice of the brain and measures biased velocities due to 2D projection. Herein, we present 3D DULM, which can extract quantitative pulsatility measurements in the cat brain with craniotomy and in the whole mouse brain through the skull, showing a wide range of flow hemodynamics in both large and small vessels. We highlighted a decrease in pulsatility along the vascular tree in the cat brain, and performed an intra-animal validation of the method by showing consistent measurements between the two sides of the Willis circle in the mouse brain. Our study provides the first step towards a new biomarker that would allow the detection of dynamic abnormalities in microvessels in the whole brain volume, which could be linked to early signs of neurodegenerative diseases.
Human review
Discussion
Know something about this paper? Leave a comment, or highlight any passage above to comment on it.