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Combining exchangeable p-values

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arxiv 2404.03484 v5 pith:4TYBUBNP submitted 2024-04-04 math.ST stat.TH

classification math.STstat.TH
keywords p-valuesexchangeablerulescombiningdependentwhenalphaarbitrarily
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abstract

The problem of combining p-values is an old and fundamental one, and the classic assumption of independence is often violated or unverifiable in many applications. There are many well-known rules that can combine a set of arbitrarily dependent p-values (for the same hypothesis) into a single p-value. We show that essentially all these existing rules can be strictly improved when the p-values are exchangeable, or when external randomization is allowed (or both). For example, we derive randomized and/or exchangeable improvements of well known rules like ``twice the median'' and ``twice the average'', as well as geometric and harmonic means. Exchangeable p-values are often produced one at a time (for example, under repeated tests involving data splitting), and our rules can combine them sequentially as they are produced, stopping when the combined p-values stabilize. Our work also improves rules for combining arbitrarily dependent p-values, since the latter becomes exchangeable if they are presented to the analyst in a random order. The main technical advance is to show that all existing combination rules can be obtained by calibrating the p-values to e-values (using an $\alpha$-dependent calibrator), averaging those e-values, converting to a level-$\alpha$ test using Markov's inequality, and finally obtaining p-values by combining this family of tests; the improvements are delivered via recent randomized and exchangeable variants of Markov's inequality.

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  1. Asymptotics in Multiple Hypotheses Testing under Dependence: beyond Normality

    math.ST 2024-11 conditional novelty 6.0 of 10

    For equicorrelated test statistics with light-tailed noise, the Bonferroni family-wise error rate goes to zero as the number of hypotheses grows, generalizing a known normal result.

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