RECORD
An eikonal model with re-excitability for fast simulations in cardiac electrophysiology
Computational Engineering, Finance, and Science · Submitted 29 Oct 2024
abstract compiled · 2026-09-23 · no language-model review
The authors' main claim The eikonal model is qualitatively accurate in the simulation of re-entries and can be potentially ran in real-time, opening the door to its clinical applicability.
The compiled record
The paper's own sentences, arranged. Each label is drawn from a closed vocabulary; the number beside it is the probability the classifier gave that label. Numbers in the tables are the authors', checked by code. No sentence in this record was written by a model.
Open the compiled record
The abstract, sentence by sentence
Precision cardiology based on cardiac digital twins requires accurate simulations of cardiac arrhythmias. However, detailed models, such as the monodomain model, are computationally costly and have limited applicability in practice. Thus, it desirable to have fast models that can still represent the main physiological features presented during cardiac arrhythmias. The eikonal model is an approximation of the monodomain model that is widely used to describe the arrival times of the electrical wave. However, the standard eikonal model does not generalize to the complex re-entrant dynamics that characterize the cardiac arrhythmias. In this work, we propose an eikonal model that includes the tissue re-excitability, which allows to describe re-entries. The re-excitability properties are inferred from the monodomain model. Our eikonal model also handles the tissue anisotropy and heterogeneity. We compare the eikonal model to the monodomain model in various numerical experiments in the atria and the ventricles. The eikonal model is qualitatively accurate in the simulation of re-entries and can be potentially ran in real-time, opening the door to its clinical applicability.
background contribution method result interpretation main claim
| # | sentence | role | the authors' own work | states the main conclusion | strength |
|---|---|---|---|---|---|
| s0 | Precision cardiology based on cardiac digital twins requires accurate simulations of cardiac arrhythmias. | background 1.00 | 0.05 | 0.03 | asserted 1.00 |
| s1 | However, detailed models, such as the monodomain model, are computationally costly and have limited applicability in practice. | background 0.79 | 0.06 | 0.02 | asserted 1.00 |
| s2 | Thus, it desirable to have fast models that can still represent the main physiological features presented during cardiac arrhythmias. | background 0.73 | 0.05 | 0.04 | asserted 0.74 |
| s3 | The eikonal model is an approximation of the monodomain model that is widely used to describe the arrival times of the electrical wave. | background 1.00 | 0.05 | 0.02 | asserted 1.00 |
| s4 | However, the standard eikonal model does not generalize to the complex re-entrant dynamics that characterize the cardiac arrhythmias. | gap 0.95 | 0.11 | 0.03 | asserted 1.00 |
| s5 | In this work, we propose an eikonal model that includes the tissue re-excitability, which allows to describe re-entries. | contribution 0.99 | 0.94 | 0.25 | asserted 1.00 |
| s6 | The re-excitability properties are inferred from the monodomain model. | method 0.97 | 0.77 | 0.03 | asserted 1.00 |
| s7 | Our eikonal model also handles the tissue anisotropy and heterogeneity. | contribution 0.72 | 0.71 | 0.05 | asserted 1.00 |
| s8 | We compare the eikonal model to the monodomain model in various numerical experiments in the atria and the ventricles. | method 0.93 | 0.96 | 0.04 | asserted 0.94 |
| s9 | The eikonal model is qualitatively accurate in the simulation of re-entries and can be potentially ran in real-time, opening the door to its clinical applicability. | result 0.58 | 0.89 | 0.87 | hedged possibility 0.59 |
What was examined, and what was not
- arXiv listing abstract v1
- full text
- figures and tables
- references and citing sentences
- relations to other papers
- P abstract
- S sections
- T body sentences
- C citations
- R cross-paper relations
The paper
Original abstract
Precision cardiology based on cardiac digital twins requires accurate simulations of cardiac arrhythmias. However, detailed models, such as the monodomain model, are computationally costly and have limited applicability in practice. Thus, it desirable to have fast models that can still represent the main physiological features presented during cardiac arrhythmias. The eikonal model is an approximation of the monodomain model that is widely used to describe the arrival times of the electrical wave. However, the standard eikonal model does not generalize to the complex re-entrant dynamics that characterize the cardiac arrhythmias. In this work, we propose an eikonal model that includes the tissue re-excitability, which allows to describe re-entries. The re-excitability properties are inferred from the monodomain model. Our eikonal model also handles the tissue anisotropy and heterogeneity. We compare the eikonal model to the monodomain model in various numerical experiments in the atria and the ventricles. The eikonal model is qualitatively accurate in the simulation of re-entries and can be potentially ran in real-time, opening the door to its clinical applicability.
Human review
How the literature uses it
1 arXiv paper cite this in 1 sentence
What it cites
Uses the method or tool of 2 papers
-
The actual solution of the local minimization problem in Eq. [ref] is carried out analytically [ref] .
GEASI: Geodesic-based Earliest Activation Sites Identification in cardiac models · Fast marching method · 0.91
-
The actual solution of the local minimization problem in Eq. [ref] is carried out analytically [ref] .
Digital twinning of cardiac electrophysiology models from the surface ECG: a geodesic backpropagation approach · Fast marching method · 0.91
Discussion
Know something about this paper? Leave a comment, or highlight any passage above to comment on it.