REVIEW 4 major objections 4 minor 38 references
SAM-Mamba: Mamba Guided SAM Architecture for Generalized Zero-Shot Polyp Segmentation
T0 review · 4 major / 4 minor · reviewed 2026-08-11 · deepseek-v4-flash
Pith's one-line read A Mamba-Prior module injected into a frozen SAM encoder improves polyp segmentation on seen and unseen colonoscopy datasets, beating the CNN and ViT baselines it is compared with.
desk verdict A novel SAM+Mamba adapter architecture worth a serious look, but the SOTA claim is built on borrowed baseline numbers that were never re-run under the same protocol. read the letter →
The pith
A machine-rendered reading of the paper's core claim, the machinery that carries it, and where it could break.
The reading
What carries the argument
The load-bearing component is the Mamba-Prior module, whose named pieces are Multi-scale Spatial Decomposition (MSD), Channel Saliency and Context Accumulation, and Mamba Channel Interaction. MSD builds a spatial feature pyramid with parallel 3x3, 5x5, and 7x7 convolutions; global max and average pooling then separate each scale into salient and contextual cues; and two Mamba layers—state-space models that process sequences with linear complexity—encode long-range dependencies over those channel distributions. The gated Mamba outputs are multiplied back into the multi-scale feature map and concatenated to form the prior, which enters SAM's frozen ViT blocks through cross-attention adapters. A pseudo-mask produced from the adapted encoder is later fed to SAM's decoder as the prompt, removing the need for user-supplied points or boxes, and the network is trained in two stages: encoder-side adapters first under deep supervision, then the decoder with the full mask loss.
What would settle it
Re-running CTNet, MEGANet, Polyp-PVT, and the other compared methods under SAM-Mamba's exact protocol (1,450 training images, 352x352 inputs, same augmentation, same evaluation protocol) and finding that any baseline reaches or exceeds 78.2% mIoU on ETIS or 77.1% mIoU on CVC-ColonDB would show the claimed zero-shot margins are not reproducible.
Extended reading notes
Core claim
The central claim is that a Mamba-based prior, rather than unfreezing SAM or adding many parameters, is what unlocks strong polyp segmentation with zero-shot generalization. The Mamba-Prior module decomposes the input image at three spatial scales using 3x3, 5x5, and 7x7 convolutions, pools the scales into separate saliency and context channels, and runs both through Mamba layers that model long-range channel dependencies at linear cost; the gated outputs are then multiplied back into the original feature map to form a domain prior that is injected into SAM's frozen ViT blocks through cross-attention adapters. On the seen datasets the model reaches 92.4% mean Dice on Kvasir-SEG and 94.2% on CVC-ClinicDB, while on the unseen CVC-ColonDB and ETIS datasets it reports 77.1% and 78.2% mean intersection-over-union, ahead of every compared CNN and ViT baseline. Ablations attribute the gain to the combination of multi-scale decomposition and Mamba, with single-scale variants losing several points on unseen datasets.
Load-bearing premise
The claimed superiority rests on baseline numbers quoted from other papers, with the paper itself noting in Section 4.3 that PEFNet's numbers come from M2UNet, rather than on re-runs under SAM-Mamba's exact protocol; if those quoted numbers were obtained under different preprocessing, training, or evaluation details, the margins could shrink or disappear.
Editorial extensions
If this is right
- If the reported numbers hold, a frozen SAM encoder plus a Mamba-Prior module beats specialized CNN and ViT polyp segmenters on both seen and unseen benchmark datasets.
- The pseudo-mask prompting pipeline makes the model usable as a fully automatic colonoscopy screening tool, since no point, box, or text prompt is required at inference.
- The module adds only about 9.5% more parameters (from 94M to 103M), so the accuracy gain does not depend on full fine-tuning of SAM.
- According to the ablations, multi-scale decomposition is necessary for generalization: single-kernel variants lose roughly 3–4 points on the unseen datasets, while the full multi-scale-plus-Mamba configuration is best everywhere.
Reading between the lines
- A direct test the paper leaves open is whether the Mamba-Prior transfers to other SAM-based medical segmentation tasks, such as organ or lesion segmentation; the same style of gain would be expected if the prior is the active ingredient.
- Because all baselines are quoted from prior publications rather than re-run, re-benchmarking them in one codebase with identical preprocessing and evaluation would either confirm or erode the reported margins.
- The module's combination of multi-scale spatial decomposition and saliency/context separation is not tied to SAM in principle; applying it to other foundation-segmentation backbones could reveal whether the benefit comes from the prior or from SAM's frozen representation.
- The abstract claims superiority over Adapter-based models, but no adapter-only baseline appears in the reported tables; a head-to-head comparison with existing SAM-adapter methods would make that claim testable.
Editorial analysis
A structured set of objections, weighed in public.
Referee Report
Summary. The paper proposes SAM-Mamba, an adapter-based fine-tuning of the Segment Anything Model (SAM) for polyp segmentation. A Mamba-Prior module, composed of multi-scale spatial decomposition (MSD), channel saliency/context pooling, and Mamba channel interaction, injects domain priors into the frozen SAM encoder. The method is trained on Kvasir-SEG and CVC-ClinicDB and evaluated in a zero-shot generalization setting on CVC-300, CVC-ColonDB, and ETIS. The authors report that SAM-Mamba outperforms CNN-, ViT-, and adapter-based models, and they provide quantitative comparisons against 14 baselines plus ablation studies.
Significance. If the claimed results are protocol-equivalent, SAM-Mamba would represent a strong new state of the art for generalized zero-shot polyp segmentation, with notable margins on unseen datasets. The architectural idea of combining SSM-based Mamba layers with SAM adapters is motivated, and the ablation study provides some evidence that the MSD and Mamba components each help. The release of code and models via GitHub is a strength that supports reproducibility. However, the significance is currently conditional, because the headline comparison relies on borrowed baseline numbers and contains an internal contradiction.
major comments (4)
- [§4.3, Table 1] The text states that on CVC-ClinicDB SAM-Mamba "outperforms peers in key metrics such as mIoU, Fβ, and Sα," but Table 1 shows MEGANet at 89.4 mIoU versus 88.7 for SAM-Mamba. The mIoU claim is therefore contradicted by the paper's own table. Please correct either the table or the text, and ensure that all reported "outperforms" statements are consistent with the numbers shown.
- [Abstract, §4.3, Tables 1-3] The abstract and Section 4.3 claim superiority over "Adapter-based models," but no adapter-based baseline appears in Tables 1-3; the only adapter comparison is the internal ablation in Table 4. Without at least one external adapter-based baseline (e.g., Medical SAM Adapter or a comparable SAM fine-tuning method) evaluated under the same protocol, the claim as stated is not supported by the presented evidence.
- [§4.2, §4.3] All baseline results are taken from the original papers, and PEFNet's numbers are taken from M2UNet, while SAM-Mamba is trained with 352x352 input, multi-scale augmentation, and 200 epochs. Since no baseline is re-run under SAM-Mamba's protocol, protocol differences in preprocessing, training split, and evaluation could account for part of the reported gains (e.g., +4.0 and +3.8 mIoU on CVC-ColonDB and ETIS). The zero-shot superiority claim needs either a like-for-like comparison for the most competitive baselines or an explicit justification that the borrowed numbers are protocol-equivalent.
- [§4.3, Tables 2-3] The claim of "outperforming all SOTA models" on unseen datasets is stated as a margin over the next best method, but on several metrics the advantage is small or reversed (e.g., SAM-Mamba's Fβ on CVC-300 is 88.8 versus CTNet's 89.4, and its E^max on CVC-ClinicDB is below several baselines). Please report the comparison more precisely, and avoid selective metric reporting when summarizing results.
minor comments (4)
- [§3.2.3, Figure 1] The notation f(θ) is used to describe the pseudo-mask extraction, but f(θ) is never formally defined in the text; please specify what this function and its parameter space θ represent.
- [Equation (3)] In Equation (3), the second concatenation operand is written as "MC_o ⊙ M*", which appears to be a typo for "M^C_o ⊙ M*"; please ensure superscript notation is consistent throughout.
- [Table 2] In the CVC-300 block, the CFA-Net row lists Fβ=93.8 and Sα=87.5; since Fβ is normally bounded by structural similarity, please verify these entries or explain why their relative ordering is plausible.
- [Abstract, Title] The dagger symbol after "SAM-Mamba" in the abstract and the footnote marker do not appear to be resolved anywhere in the text; please either add the promised footnote or remove the symbol.
Circularity Check
No significant circularity: the paper is an empirical architecture study whose results come from external benchmark evaluation, not from a derivation that reduces to its inputs.
full rationale
SAM-Mamba is an empirical architecture paper. Its central claim, outperforming prior CNN, ViT, and adapter-based methods on polyp segmentation, is supported by evaluations on five public datasets under the standard PraNet-style split, with the model trained on the seen split and tested on unseen datasets. There is no fitted parameter, no theory-derived constant, and no equation in Sections 3.2.1–3.2.4 whose output is defined in terms of the claimed result; the Mamba-Prior module and adapters are trained with Dice/BCE losses against ground truth and then evaluated externally. The paper's use of the authors' Kvasir-SEG dataset is citation of a public benchmark, not load-bearing self-citation. The note in Section 4.3 that PEFNet results are sourced from M2UNet and that other baselines are taken from their original works is a transparency statement about borrowed metrics; it raises a legitimate protocol-comparability concern, but it is not circularity because SAM-Mamba's own numbers are independently computed and the quoted baseline numbers do not by construction determine the reported margins. No step in the paper reduces a prediction to a fit or renames an input as an output, so the appropriate finding is no significant circularity.
Assumptions & free parameters
free parameters (6)
- Learning rate =
1e-5
- Training epochs =
200
- Input resolution =
352x352
- MSD kernel sizes =
{3,5,7}
- Loss weights (w in Dice/BCE) =
not specified
- MSD output channels C0 =
not specified
assumptions (4)
- domain assumption SAM's frozen pretrained features are transferable to polyp images through adapter-based fine-tuning
- domain assumption The PraNet benchmark split and the six evaluation metrics are valid proxies for clinical polyp segmentation quality
- ad hoc to paper Global max/avg pooling followed by Mamba channel interaction captures useful multi-scale context for polyps
- domain assumption Baseline results reported in prior papers are directly comparable to the authors' runs
Cite this review
Pith. "Pith review of SAM-Mamba: Mamba Guided SAM Architecture for Generalized Zero-Shot Polyp Segmentation." pith.science (2026). https://pith.science/paper/P3P2N4ZA
@misc{pith2026241208482,
author = {Pith},
title = {Pith review of: SAM-Mamba: Mamba Guided SAM Architecture for Generalized Zero-Shot Polyp Segmentation},
year = {2026},
howpublished = {\url{https://pith.science/paper/P3P2N4ZA}},
note = {Machine review of arXiv:2412.08482}
}
read the original abstract
Polyp segmentation in colonoscopy is crucial for detecting colorectal cancer. However, it is challenging due to variations in the structure, color, and size of polyps, as well as the lack of clear boundaries with surrounding tissues. Traditional segmentation models based on Convolutional Neural Networks (CNNs) struggle to capture detailed patterns and global context, limiting their performance. Vision Transformer (ViT)-based models address some of these issues but have difficulties in capturing local context and lack strong zero-shot generalization. To this end, we propose the Mamba-guided Segment Anything Model (SAM-Mamba) for efficient polyp segmentation. Our approach introduces a Mamba-Prior module in the encoder to bridge the gap between the general pre-trained representation of SAM and polyp-relevant trivial clues. It injects salient cues of polyp images into the SAM image encoder as a domain prior while capturing global dependencies at various scales, leading to more accurate segmentation results. Extensive experiments on five benchmark datasets show that SAM-Mamba outperforms traditional CNN, ViT, and Adapter-based models in both quantitative and qualitative measures. Additionally, SAM-Mamba demonstrates excellent adaptability to unseen datasets, making it highly suitable for real-time clinical use.
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