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arxiv: 2509.02376 · v2 · submitted 2025-09-02 · 📊 stat.ME · math.ST· stat.TH

Resampling-based multi-resolution false discovery exceedance control

Pith reviewed 2026-05-18 19:54 UTC · model grok-4.3

classification 📊 stat.ME math.STstat.TH
keywords false discovery exceedancemultiple testingresamplingsimultaneous controlfalse discovery proportionfamilywise error rateconfidence envelopes
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The pith

A resampling method outputs one threshold but bounds the false discovery proportion for all stricter thresholds at once.

A machine-rendered reading of the paper's core claim, the machinery that carries it, and where it could break.

The paper generalizes a popular resampling approach for multiple testing so that a single chosen rejection threshold comes with guarantees that hold simultaneously for every stricter threshold. Specifically, the false discovery proportion stays below a fixed level gamma with probability at least one minus alpha for the chosen threshold and all stricter ones alike. For very small sets of hypotheses this implies zero false discoveries with high probability. The method keeps power comparable to the strongest existing non-simultaneous false discovery exceedance procedures and requires only the same assumptions those procedures already use. A reader would care because the extra simultaneous layer supplies more robust error control in dependent data without an obvious power penalty.

Core claim

The proposed procedure outputs a single rejection threshold q but ensures that with probability 1-α, simultaneously over all stricter thresholds, the corresponding false discovery proportions are also below γ. In particular, for a small set of hypotheses the false discovery bound is 0. Despite these additional simultaneous guarantees the method has power comparable to the most powerful non-simultaneous false discovery exceedance procedure. The method remains valid under the same assumptions and can be viewed as an extension of prior simultaneous approaches that for the first time permits confidence envelopes whose shape depends on the data.

What carries the argument

Multi-resolution false discovery exceedance control, a resampling extension that enforces simultaneous false discovery proportion bounds across all stricter thresholds from one chosen cutoff.

If this is right

  • The procedure forces the familywise error rate to zero for small collections of hypotheses.
  • Power stays comparable to the strongest existing non-simultaneous false discovery exceedance methods.
  • Validity continues to rest on exactly the same assumptions required by earlier false discovery exceedance procedures.
  • The approach supplies confidence envelopes whose shape can depend on the observed data, removing a previous restriction on simultaneous methods.

Where Pith is reading between the lines

These are editorial extensions of the paper, not claims the author makes directly.

  • Analysts could obtain layered error statements at several significance levels from a single computation.
  • The construction may transfer to other resampling-based error rates that currently lack simultaneous versions.
  • Fields that routinely explore data at varying stringency levels might adopt the procedure to reduce the chance of post-hoc threshold adjustments.
  • The result suggests that simultaneous properties can often be added to existing false discovery exceedance methods with little extra cost.

Load-bearing premise

The underlying resampling step must correctly capture the dependence structure among the test statistics.

What would settle it

Repeated simulations or real-data applications in which the observed false discovery proportion for at least one stricter threshold exceeds γ with frequency greater than α would show that the simultaneous guarantee fails.

Figures

Figures reproduced from arXiv: 2509.02376 by Jesse Hemerik.

Figure 1
Figure 1. Figure 1: The power of the single-step FDX method as depending on [PITH_FULL_IMAGE:figures/full_fig_p014_1.png] view at source ↗
Figure 2
Figure 2. Figure 2: Scatterplot showing the number of rejections of the new method versus the number [PITH_FULL_IMAGE:figures/full_fig_p015_2.png] view at source ↗
Figure 3
Figure 3. Figure 3: The power of the new method (“New”) versus Romano-Shaikh (“RS”), [PITH_FULL_IMAGE:figures/full_fig_p019_3.png] view at source ↗
Figure 4
Figure 4. Figure 4: The power of the fast (“New”, “HSG”, “RW”) and computationally intensive [PITH_FULL_IMAGE:figures/full_fig_p020_4.png] view at source ↗
read the original abstract

MaxT is a highly popular resampling-based multiple testing procedure, which controls the Familywise Error Rate (FWER) and is powerful under dependence. This paper generalizes maxT to what we term ``multi-resolution'' False Discovery eXceedance (FDX) control. Basic FDX control means ensuring that the FDP -- the proportion of false discoveries among all rejections -- is at most $\gamma$ with probability at least $1-\alpha$. Here $\gamma$ and $\alpha$ are prespecified, small values between 0 and 1. The proposed method is in addition simultaneous, in the following way: the procedure outputs a single rejection threshold $q$, but ensures that with probability $1-\alpha$, simultaneously over all stricter thresholds, the corresponding FDPs are also below $\gamma$. In particular, for a small set of hypotheses, the FDP bound is 0, i.e., the FWER is 0. Despite these additional, simultaneous guarantees, our method has power comparable to Romano-Wolf, the most powerful non-simultaneous FDX method. Further, our method is valid under the same assumptions. Thus, this paper shows that FDX methods can often be made simultaneous almost for free. The proposed method can be formulated as an extension of simultaneous approaches such as Hemerik, Solari and Goeman (2019), for the first time allowing for confidence envelopes with a data-dependent shape -- thus resolving a major limitation of such methods.

Editorial analysis

A structured set of objections, weighed in public.

Desk editor's note, referee report, simulated authors' rebuttal, and a circularity audit. Tearing a paper down is the easy half of reading it; the pith above is the substance, this is the friction.

Referee Report

2 major / 2 minor

Summary. The manuscript proposes a resampling-based generalization of the MaxT procedure for multi-resolution false discovery exceedance (FDX) control. It outputs a single data-dependent threshold q such that, with probability at least 1-α, the false discovery proportion remains below a prespecified γ simultaneously for all stricter thresholds q' ≤ q (including FWER control when the number of rejections is small). The method is presented as an extension of Hemerik-Solari-Goeman simultaneous envelopes to data-dependent shapes via resampling, with validity claimed under the same assumptions as standard FDX procedures and power comparable to the Romano-Wolf method.

Significance. If the validity argument holds, the result would be significant for the multiple-testing literature: it shows that simultaneous FDX control can be obtained with little or no power loss relative to non-simultaneous resampling methods, while resolving the fixed-shape limitation of prior envelope approaches. This could be useful in dependent high-dimensional settings where both FDX control and interpretability across resolution levels matter. The paper correctly credits the underlying resampling framework and the Hemerik et al. (2019) envelopes.

major comments (2)
  1. [§3.2] §3.2, Theorem 1 (or the main validity result): the claim that the simultaneous FDP control over the entire path q' ≤ q follows directly from the marginal MaxT resampling quantiles is not fully supported by the standard subset-pivotality or exchangeability assumptions used for single-threshold FDX. An additional uniform convergence or monotonicity argument on the empirical FDP process appears necessary to guarantee that the resampling envelope dominates the joint tail; without it the multi-resolution property does not automatically inherit.
  2. [§4.1] §4.1–4.2 (simulation design): the reported power comparisons with Romano-Wolf are useful, but the tables do not separately tabulate the empirical probability that the simultaneous guarantee is violated (i.e., sup_{q'≤q} FDP(q') > γ). This quantity is load-bearing for the central claim and should be reported under both global-null and sparse-alternative regimes.
minor comments (2)
  1. [§2.3] Notation for the data-dependent shape function in the envelope construction is introduced without an explicit display equation; adding a displayed definition would improve readability.
  2. [Abstract] The abstract states that the method is 'valid under the same assumptions' as prior FDX methods, but the precise list of assumptions (e.g., whether positive regression dependence or only exchangeability is required) is only given later; moving a concise statement to the abstract or introduction would help.

Simulated Author's Rebuttal

2 responses · 0 unresolved

We thank the referee for their thoughtful and constructive comments on our manuscript. We address each major comment below and describe the revisions we plan to make.

read point-by-point responses
  1. Referee: [§3.2] §3.2, Theorem 1 (or the main validity result): the claim that the simultaneous FDP control over the entire path q' ≤ q follows directly from the marginal MaxT resampling quantiles is not fully supported by the standard subset-pivotality or exchangeability assumptions used for single-threshold FDX. An additional uniform convergence or monotonicity argument on the empirical FDP process appears necessary to guarantee that the resampling envelope dominates the joint tail; without it the multi-resolution property does not automatically inherit.

    Authors: We appreciate the referee's careful reading. The threshold q is defined as the infimum of values where the resampling envelope lies below γ, and the monotonicity of the rejection sets (stricter thresholds yield subsets of rejections) together with the marginal validity of the maxT quantiles ensures that the bound holds simultaneously over q' ≤ q. Nevertheless, we agree that an explicit supporting argument would strengthen the presentation. In the revision we will insert a short lemma in Section 3 establishing that the empirical FDP process is non-increasing in the threshold under the maintained exchangeability conditions; combined with the marginal controls this yields the joint guarantee without requiring additional uniform-convergence assumptions beyond those already used for single-threshold FDX. revision: yes

  2. Referee: [§4.1] §4.1–4.2 (simulation design): the reported power comparisons with Romano-Wolf are useful, but the tables do not separately tabulate the empirical probability that the simultaneous guarantee is violated (i.e., sup_{q'≤q} FDP(q') > γ). This quantity is load-bearing for the central claim and should be reported under both global-null and sparse-alternative regimes.

    Authors: We concur that reporting the finite-sample violation rate of the simultaneous guarantee is a valuable diagnostic. In the revised manuscript we will augment the simulation tables in Sections 4.1 and 4.2 with an additional column (or a new supplementary table) that records the Monte Carlo estimate of P(sup_{q' ≤ q} FDP(q') > γ) for our procedure, under both the global-null and sparse-alternative regimes. This will be computed at the nominal α level and compared against the theoretical bound. revision: yes

Circularity Check

1 steps flagged

Minor self-citation to prior simultaneous FDX work; core multi-resolution extension independently motivated and not reduced to fitted inputs

specific steps
  1. self citation load bearing [Abstract]
    "The proposed method can be formulated as an extension of simultaneous approaches such as Hemerik, Solari and Goeman (2019), for the first time allowing for confidence envelopes with a data-dependent shape -- thus resolving a major limitation of such methods."

    The simultaneous multi-resolution guarantee and validity under identical assumptions are positioned as following from the cited prior work by overlapping authors; while presented as a novel extension, the load-bearing justification for inheriting the full envelope control without additional uniformity arguments reduces to this self-citation chain rather than a standalone derivation.

full rationale

The paper presents a resampling-based generalization of maxT for simultaneous multi-resolution FDX control, claiming validity under the same assumptions as prior FDX methods and power comparable to Romano-Wolf. It explicitly formulates the method as an extension of Hemerik-Solari-Goeman (2019) to allow data-dependent shapes. This constitutes one minor self-citation (author overlap) that is not load-bearing for the central claim, as the multi-resolution property and simultaneous guarantee are motivated independently via the resampling construction rather than by redefining or fitting quantities inside the paper. No self-definitional steps, fitted inputs renamed as predictions, or ansatz smuggling appear in the provided abstract or description. The derivation remains self-contained against external resampling benchmarks.

Axiom & Free-Parameter Ledger

2 free parameters · 1 axioms · 0 invented entities

The central claim rests on the validity of the base resampling procedure for FWER control and on the prespecified parameters gamma and alpha; no new entities are introduced.

free parameters (2)
  • gamma
    Prespecified upper bound on the false discovery proportion
  • alpha
    Prespecified probability level for the exceedance control
axioms (1)
  • domain assumption Resampling procedure (as in MaxT) controls the relevant error rate under the dependence structure present in the data
    Invoked when the abstract states the new method is valid under the same assumptions as prior FDX methods

pith-pipeline@v0.9.0 · 5792 in / 1300 out tokens · 46790 ms · 2026-05-18T19:54:47.853545+00:00 · methodology

discussion (0)

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Reference graph

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    " write newline "" before.all 'output.state := FUNCTION n.dashify 't := "" t empty not t #1 #1 substring "-" = t #1 #2 substring "--" = not "--" * t #2 global.max substring 't := t #1 #1 substring "-" = "-" * t #2 global.max substring 't := while if t #1 #1 substring * t #2 global.max substring 't := if while FUNCTION format.date year duplicate empty "emp...