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arxiv: 2605.16146 · v1 · pith:4X7K2QLWnew · submitted 2026-05-15 · 🧬 q-bio.NC

The Complex Brain Hypothesis: Resolving the Entropy-Content Conundrum in Minimal Phenomenal Experience

Pith reviewed 2026-05-19 18:30 UTC · model grok-4.3

classification 🧬 q-bio.NC
keywords minimal phenomenal experiencecomplex brain hypothesisentropic brain hypothesisbrain complexityentropyconsciousnessmeditationpsychedelics
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The pith

Brain complexity, not entropy, better indexes the difference between minimal and high-content phenomenal experiences.

A machine-rendered reading of the paper's core claim, the machinery that carries it, and where it could break.

The paper advances the Complex Brain Hypothesis to resolve a puzzle for the Entropic Brain Hypothesis. Recent studies show that minimal phenomenal experiences, such as those in certain meditation states, can exhibit elevated brain entropy even though they lack the rich content seen in psychedelic experiences. The authors argue that complexity, shaped by the grain of inference the brain uses to resolve uncertainty, distinguishes these states: fine-grained inference produces proliferating content while coarse-grained inference yields contentless awareness. A sympathetic reader would care because this distinction preserves the link between entropy and certain altered states while explaining why entropy alone does not track phenomenal richness.

Core claim

The Complex Brain Hypothesis proposes that the richness of experience differentiating MPEs from HCPEs is better indexed by complexity than by entropy. Brain complexity is modulated by the grain of inference through which the brain resolves uncertainty: some HCPEs exemplify a fine-grained regime, in which loosened constraints amplify fluctuations into proliferating content, whereas some MPEs exemplify a coarse-grained regime, in which a simpler model dissolves variety into an experience of 'contentless' awareness. Both regimes can be associated with elevated brain entropy, but they diverge in phenomenology and perturbational signatures.

What carries the argument

The Complex Brain Hypothesis (CBH), which holds that richness of experience is indexed by complexity rather than entropy and is modulated by the grain of inference used to resolve uncertainty.

If this is right

  • Both minimal and high-content states can exhibit high entropy while differing in their complexity signatures.
  • Phenomenal richness depends on whether the brain's model operates at a fine or coarse grain of inference.
  • Perturbational complexity or related measures should differ between MPEs and HCPEs even when entropy is similarly elevated.
  • MPEs become a key test case that refines rather than contradicts the Entropic Brain Hypothesis.
  • Computational theories of consciousness must incorporate granularity of inference to explain contentless awareness.

Where Pith is reading between the lines

These are editorial extensions of the paper, not claims the author makes directly.

  • Interventions that shift inference granularity, such as specific meditation techniques, could predictably move a person between minimal and content-rich states.
  • The framework suggests entropy and complexity should be measured jointly in future studies of altered states to avoid conflating them.
  • If the distinction holds, it may help explain why some high-entropy states feel empty while others feel filled with content.

Load-bearing premise

That recent neuroimaging studies of meditation-induced and possibly 5-MeO-DMT-induced states show increased neurophysiological entropy, while the Entropic Brain Hypothesis treats entropy as a direct marker of phenomenal richness.

What would settle it

A direct comparison showing that complexity measures fail to differentiate MPEs from HCPEs more effectively than entropy measures do, or that perturbational signatures do not diverge between the two despite matched entropy levels.

Figures

Figures reproduced from arXiv: 2605.16146 by Edmundo Lopez-Sola, Jakub Vohryzek, Jonas Mago, Karl Friston, Michael Lifshitz, Robin Carhart-Harris, Shamil Chandaria.

Figure 1
Figure 1. Figure 1: Free energy as a trade-off between complexity and accuracy. The variational free energy F can be decomposed into a complexity term and an accuracy term. Complexity corresponds to the Kullback–Leibler divergence between posterior and prior beliefs, 𝐷{"#}[𝑄(𝑥)||𝑃(𝑥)], and reflects the degree to which posterior beliefs must deviate from prior expectations to account for sensory data. Accuracy corresponds to t… view at source ↗
Figure 2
Figure 2. Figure 2: The entropy–content conundrum. The entropic brain hypothesis (EBH) implies a monotonic mapping from phenomenological content to entropy. This would predict that minimal-content states are associated with low entropy while content-rich states are associated with high entropy. However, empirical evidence indicates that both MPEs (e.g., jhāna, 5-MeO￾DMT) and HCPEs (e.g., LSD, psilocybin, N,N-DMT) exhibit elev… view at source ↗
Figure 4
Figure 4. Figure 4: Solving the conundrum: complexity, entropy and phenomenal richness. Conceptual illustration of the relationship between model complexity (black), entropy (red), and phenomenal richness. The left panels recapitulate the three regimes of inference in [PITH_FULL_IMAGE:figures/full_fig_p012_4.png] view at source ↗
Figure 5
Figure 5. Figure 5: Entropy and complexity in the coffee–cream mixing process (adapted from Aaronson et al., 2014). As black coffee and white cream mix, entropy increases monotonically, reflecting the growing number of particle configurations consistent with the systems state. At coarse-grained scales, however, complexity rises during the formation of structured swirls and then collapses once the mixture becomes uniform, illu… view at source ↗
Figure 6
Figure 6. Figure 6: Entropy rises in both HCPEs and absorptive states, but complexity diverges depending on the inferential regime. The red curve depicts the entropy of posterior beliefs or their neuronal parameterization; it increases monotonically as prior constraints are relaxed. The purple curve represents complexity under fine-grained HCPE inference: unattenuated sensory fluctuations are amplified into proliferating cont… view at source ↗
Figure 7
Figure 7. Figure 7: Three-dimensional extension of the entropic brain hypothesis. (a) A three￾dimensional schematic showing how adding a third variable, here labeled wakefulness, separates states with low phenomenal richness and high entropy (MPE) or low entropy (sleep). When this surface is projected onto the two-dimensional plane, the pattern in panel (b) emerges. (b) [PITH_FULL_IMAGE:figures/full_fig_p017_7.png] view at source ↗
read the original abstract

Minimal Phenomenal Experiences (MPEs) are states of consciousness in which wakefulness is preserved but phenomenal content is low or absent. The Entropic Brain Hypothesis (EBH) is a model of conscious processes that regards the entropy of spontaneous brain activity as a marker of 'phenomenal richness', exemplified by high-content psychedelic experiences (HCPEs). Yet recent human neuroimaging studies of MPEs induced by meditation -- and possibly 5-MeO-DMT -- suggest that these states, defined by their phenomenological simplicity, also show signs of increased neurophysiological entropy. This presents a conundrum for the EBH: brain entropy is elevated with increased and decreased richness of the phenomenal experience. Here, we put forward the Complex Brain Hypothesis (CBH), which proposes that the richness of experience differentiating MPEs from HCPEs is better indexed by complexity than by entropy. We argue that brain complexity is modulated by the grain of inference through which the brain resolves uncertainty: some HCPEs exemplify a fine-grained regime, in which loosened constraints amplify fluctuations into proliferating content, whereas some MPEs exemplify a coarse-grained regime, in which a simpler model dissolves variety into an experience of 'contentless' awareness. Both regimes can be associated with elevated brain entropy, but they diverge in phenomenology and perturbational signatures. By resolving the entropy-content conundrum, the CBH refines the EBH and highlights MPEs as an important test case for computational theories of consciousness.

Editorial analysis

A structured set of objections, weighed in public.

Desk editor's note, referee report, simulated authors' rebuttal, and a circularity audit. Tearing a paper down is the easy half of reading it; the pith above is the substance, this is the friction.

Referee Report

2 major / 2 minor

Summary. The manuscript proposes the Complex Brain Hypothesis (CBH) to resolve an apparent conundrum in the Entropic Brain Hypothesis (EBH). It claims that both minimal phenomenal experiences (MPEs, e.g., from meditation or possibly 5-MeO-DMT) and high-content psychedelic experiences (HCPEs) can exhibit elevated brain entropy, yet differ in phenomenal richness because complexity (not entropy) tracks content; this difference arises from the grain of inference, with coarse-grained regimes in MPEs dissolving variety into contentless awareness and fine-grained regimes in HCPEs amplifying fluctuations into rich content.

Significance. If the proposed dissociation holds, the CBH would usefully refine the EBH by separating entropy from complexity as markers of phenomenal richness and would position MPEs as an important test case for computational theories of consciousness. The manuscript offers a clear conceptual reframing that could guide future perturbational and neuroimaging work, though its strength currently rests on reinterpretation rather than new derivations or data.

major comments (2)
  1. [Section introducing the Complex Brain Hypothesis (near the end of the abstract and corresponding discussion)] The manuscript asserts that coarse-grained inference yields high entropy yet low complexity (and thus low phenomenal content) in MPEs, but provides no equation, simulation, or explicit mapping from inference granularity to a concrete complexity measure such as Lempel-Ziv complexity, multiscale entropy, or integrated information. Without this link the central claim that complexity resolves the entropy-content conundrum remains qualitative and does not yet demonstrate why the same entropy elevation must produce divergent phenomenology.
  2. [Discussion of human neuroimaging studies of MPEs induced by meditation and 5-MeO-DMT] The argument relies on prior neuroimaging findings of elevated entropy in MPEs; however, the distinction between fine- and coarse-grained regimes appears defined in terms of those same results rather than independent benchmarks. This risks circularity when the CBH is offered as a resolution of the EBH conundrum.
minor comments (2)
  1. [Terminology throughout the CBH proposal] The terms 'grain of inference', 'fine-grained regime', and 'coarse-grained regime' would benefit from more precise operational definitions or references to existing formalisms in predictive-processing or active-inference literature.
  2. [Paragraph contrasting phenomenology and perturbational signatures] Perturbational signatures that are said to diverge between the two regimes are mentioned but not illustrated with specific TMS-EEG or similar metrics; adding a brief table or figure summarizing expected signatures would improve clarity.

Simulated Author's Rebuttal

2 responses · 0 unresolved

We thank the referee for their constructive and insightful comments, which help clarify how the Complex Brain Hypothesis can be more rigorously presented. We address each major comment below, indicating planned revisions where appropriate.

read point-by-point responses
  1. Referee: [Section introducing the Complex Brain Hypothesis (near the end of the abstract and corresponding discussion)] The manuscript asserts that coarse-grained inference yields high entropy yet low complexity (and thus low phenomenal content) in MPEs, but provides no equation, simulation, or explicit mapping from inference granularity to a concrete complexity measure such as Lempel-Ziv complexity, multiscale entropy, or integrated information. Without this link the central claim that complexity resolves the entropy-content conundrum remains qualitative and does not yet demonstrate why the same entropy elevation must produce divergent phenomenology.

    Authors: We agree that the central claim of the CBH is currently presented at a conceptual level without explicit equations or simulations mapping inference granularity to specific complexity metrics. The manuscript's aim is to offer a theoretical reframing that distinguishes entropy from complexity via the grain of inference, drawing on existing predictive-processing ideas rather than deriving new quantitative models. In revision, we will add a dedicated subsection that sketches an explicit conceptual mapping: for example, relating coarse-grained inference to reduced multiscale entropy at finer temporal scales (while preserving overall entropy) and fine-grained inference to increased Lempel-Ziv complexity through amplified local fluctuations. This will include references to relevant computational literature and outline how future simulations could test the dissociation, thereby strengthening the link between inference grain and divergent phenomenology. revision: partial

  2. Referee: [Discussion of human neuroimaging studies of MPEs induced by meditation and 5-MeO-DMT] The argument relies on prior neuroimaging findings of elevated entropy in MPEs; however, the distinction between fine- and coarse-grained regimes appears defined in terms of those same results rather than independent benchmarks. This risks circularity when the CBH is offered as a resolution of the EBH conundrum.

    Authors: We acknowledge the risk of circularity and will revise the manuscript to clarify that the fine- versus coarse-grained regimes are defined independently from the neuroimaging data, drawing instead from the theoretical framework of hierarchical predictive processing in which inference grain refers to the spatial and temporal scale at which uncertainty is resolved (e.g., as formalized in active inference models). The MPE and HCPE findings are then interpreted as exemplars of these pre-defined regimes. To further mitigate circularity, the revised text will emphasize that the CBH generates testable predictions for new experiments using independent measures of inference grain, such as task-based paradigms or perturbational complexity indices, rather than relying solely on post-hoc reinterpretation of existing entropy results. revision: yes

Circularity Check

0 steps flagged

No significant circularity; CBH is a conceptual proposal building on but not reducing to EBH inputs

full rationale

The paper identifies a conundrum between EBH predictions and recent MPE neuroimaging data, then proposes CBH as a refinement in which complexity (modulated by inference grain) indexes phenomenal richness instead of entropy. No equations, fitted parameters, or self-citations are shown to make any central claim equivalent to its inputs by construction. The grain-of-inference distinction is presented as a qualitative regime argument rather than a tautological redefinition or statistical fit of the same data. The derivation remains self-contained as a hypothesis that can be tested against independent benchmarks outside the cited EBH framework.

Axiom & Free-Parameter Ledger

0 free parameters · 2 axioms · 1 invented entities

The proposal rests on domain assumptions from prior neuroimaging studies and the Entropic Brain Hypothesis; no free parameters or new invented entities with independent evidence are introduced in the abstract.

axioms (2)
  • domain assumption Entropy of spontaneous brain activity marks phenomenal richness
    Invoked as the basis of the Entropic Brain Hypothesis and the observed conundrum.
  • domain assumption MPEs induced by meditation and possibly 5-MeO-DMT exhibit increased neurophysiological entropy
    Cited as the empirical observation creating the puzzle for the existing hypothesis.
invented entities (1)
  • Complex Brain Hypothesis no independent evidence
    purpose: To index phenomenal richness by complexity rather than entropy via grain of inference
    New conceptual framework introduced to resolve the conundrum.

pith-pipeline@v0.9.0 · 5829 in / 1298 out tokens · 61867 ms · 2026-05-19T18:30:01.655205+00:00 · methodology

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Reference graph

Works this paper leans on

19 extracted references · 19 canonical work pages · 1 internal anchor

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    The Complex Brain Hypothesis: Resolving the Entropy-Content Conundrum in Minimal Phenomenal Experience Jonas Mago1+* , Edmundo Lopez-Sola2,3+, Jakub Vohryzek2,3+, Michael Lifshitz4,5, Robin Carhart-Harris6,7, Karl Friston8, Shamil Chandaria2 + Shared first authorship * Corresponding author: jonas.h.mago@gmail.com 1 Integrated Program in Neuroscience, McGi...

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    On this view, there is a close relationship between the entropy of brain activity and the entropy of beliefs encoded by brain activity that arises in several settings. For example, the principles of efficient encoding suggest that the variational and thermodynamic free energy share the same minima (Sengupta et al., 2013, 2016). Free energy corresponds to ...

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    Free energy as a trade-off between complexity and accuracy. The variational free energy F can be decomposed into a complexity term and an accuracy term. Complexity corresponds to the Kullback–Leibler divergence between posterior and prior beliefs, 𝐷{"#}[𝑄(𝑥)||𝑃(𝑥)], and reflects the degree to which posterior beliefs must deviate from prior expectations to...

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    Solving the conundrum: complexity, entropy and phenomenal richness. Conceptual illustration of the relationship between model complexity (black), entropy (red), and phenomenal richness. The left panels recapitulate the three regimes of inference in Figure 3 that inherit from reduced prior precision in the context of unattenuated and attenuated sensory (i....

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