Pith. sign in

REVIEW 2 major objections 3 minor 52 references

Three Generations of Healthcare IT: From the Digital Record to the Computable Care Process

T0 review · 2 major / 3 minor · reviewed 2026-08-14 · deepseek-v4-flash

Pith's one-line read Patient-specific clinical intent can be made computable by recovering intended actions from ordinary clinical communication as structured, executable records.

desk verdict Worth engaging: a clear conceptual framework for computable clinical intent, with a load-bearing gap about what counts as a faithful recovery of intent that a good review can help close. read the letter →

arxiv 2608.08806 v1 pith:3KY5YT2S submitted 2026-08-09 cs.AI

classification cs.AI
keywords electronichealthrecordsclinicalworkflowactionablerecordintentFHIRcomputationallayerscommunicationtemporalreasoning
verification ladder T0 review T1 audit T2 compute T3 formal

The pith

A machine-rendered reading of the paper's core claim, the machinery that carries it, and where it could break.

The reading

Healthcare information technology, the paper argues, is best organized by the unit of information a system makes computable rather than by the technology it adopts. On that basis it derives three cumulative computational layers: the clinical record, the clinical state, and a proposed third layer of patient-specific clinical intent. The paper's central claim is that this third layer can be built by recovering intended actions from ordinary clinical communication and representing each action as an Actionable Clinical Record (ACR), a structured object that names the action, target, responsible person, timing, conditions, dependencies, status, provenance, and confidence. If the claim is correct, an instruction such as 'repeat the complete blood count in two weeks' or 'refer to cardiology if symptoms persist' could become a machine-readable task that a scheduler or results system can execute, monitor, and close. That would directly target well-documented loop-closure failures, such as missed test-result follow-up and specialist referrals that never reach a completed visit.

What carries the argument

The central object is the Actionable Clinical Record (ACR), a source-grounded representation of one patient-specific intended clinical action, defined as the tuple above. It carries the argument by giving recovery a precise target: an action is not fully recovered until it can be executed, monitored, and audited, not merely indexed. Supporting machinery includes the five markers that define a computational layer (a new atomic unit, an external driver, an enabling technology, a new class of computation, and a residual limitation), the distinction among prescribed, observed, and intended process, the readiness ladder from mentioned through interpreted and actionable to executable, and an evaluation framework built on executable-correctness measures rather than text overlap. The paper also specifies a hybrid architecture in which learned components extract candidate actions and arguments while deterministic components compute times, due dates, and dependency ordering, with selective prediction routing uncertain cases to clinicians.

What would settle it

Take a set of de-identified outpatient notes with independently labeled intended actions, run the proposed hybrid recovery pipeline, and ask clinicians whether each output ACR is executable and faithful to the original instruction; if a large fraction of actions require correction or the deterministic time reasoning cannot populate temporal constraints, the paper's central claim about recovering executable intent is not supported.

Watch

Extended reading notes

Core claim

The paper's discovery, stated on its own terms, is that after a first generation made the clinical record computable and a second made the clinical fact computable, a third generation can make patient-specific clinical intent computable by recovering it from communication as a structured, executable representation. The atomic object of that layer is the ACR, a source-grounded tuple $ACR = \langle \text{action}, \text{target}, \text{actor}, \text{temporal constraint}, \text{condition}, \text{dependency}, \text{status}, \text{provenance}, \text{confidence} \rangle$, in which action, status, and provenance are required and the remaining attributes are populated when communicated or explicitly inferred. The paper locates the gap that motivates the layer: existing workflow standards such as FHIR represent intended process once it has been structured, but they do not recover it from natural communication, and it is that recovery and conversion into executable form that the third layer supplies. The paper frames the third layer as a prospective hypothesis and analytic lens rather than an established periodization, and it separates representational readiness (mentioned, interpreted, actionable, executable) from the operational lifecycle captured by the status attribute.

Load-bearing premise

The load-bearing assumption is that the intended actions expressed in clinical communication contain enough explicit or reliably inferable detail about what should happen, when, under what condition, and by whom for a recovered ACR to be executable and to match what the clinician meant.

Editorial extensions

If this is right

  • A working third layer would let a follow-up instruction like 'repeat the complete blood count in two weeks' be scheduled automatically, with responsibility assigned and completion tracked, reducing missed-result and referral loop-closure failures.
  • ACRs are designed to sit upstream of existing workflow infrastructure: they map onto FHIR resources such as CarePlan, ServiceRequest, and Task, so the proposal does not require replacing current systems.
  • Evaluation of intent recovery would shift from text-overlap scores to executable-correctness measures, including action-time linking error, unsupported-action and omitted-action rates, and calibration of confidence.
  • The framework predicts that machine-actionable use of workflow resources will grow relative to free-text follow-up, that ambient documentation will extend from notes to tasks and orders, and that reliable systems will expose source-linked, auditable records with selective human review.
  • Reliability would depend on a hybrid design: language models propose candidate actions, deterministic reasoning resolves times and dependencies, and the system abstains or alerts a clinician on uncertain cases rather than acting automatically.

Reading between the lines

Editorial extensions of the paper, not claims the author makes directly.

  • The ACR schema is presented for follow-up instructions, but the paper names a broader class of communication-derived process objects; one extension is to develop the same tuple for conditional escalations, medication transitions, handoffs, and pending-result responsibility, where the dependency and condition attributes would do most of the work.
  • If ACR recovery matures, a natural testable extension is a randomized comparison of ACR-driven closed-loop task management against usual care on referral completion and test-result follow-up; the paper itself stops at executable-correctness evaluation, so this outcome study is an inference, not a claim.
  • The readiness ladder implies a staged adoption path: start with human confirmation of recovered actions, then automate only low-risk, well-calibrated actions; this could make regulatory approval incremental, though the paper does not say so.
  • Because the ACR separates speaker from responsible actor, it could support accountability and audit use; making that work would require solving role ambiguity, which the paper lists as open research rather than a solved problem.
Share X Bluesky LinkedIn Reddit HN

Signed reviews

No signed human review yet.

Editorial analysis

A structured set of objections, weighed in public.

Desk editor's note, referee report, and a circularity audit.

Referee Report

2 major / 3 minor

Summary. This Perspective paper proposes an organizing framework for healthcare IT based on the unit of information made computable, distinguishing three layers: clinical record (Layer 1), clinical state (Layer 2), and clinical intent (Layer 3, proposed). It introduces the Actionable Clinical Record (ACR) as the atomic object of Layer 3, defined as a nine-attribute tuple (action, target, actor, temporal constraint, condition, dependency, status, provenance, confidence), and describes a readiness ladder from mentioned to executable, a hybrid architecture of learned extraction with deterministic reasoning, and an evaluation framework centered on executable correctness rather than text overlap. The paper is explicitly a conceptual contribution, not an empirical study; the companion feasibility study [51] addresses one narrow subproblem. The authors position the proposal as a research program with falsifiable predictions, including tests of whether the ACR representation is redundant if direct FHIR mapping suffices.

Significance. The paper's main contribution is conceptual: it offers a crisp vocabulary for the problem of computable clinical intent and introduces constructs—the ACR and the executable-correctness evaluation framework—that could be reused and extended by the community. The explicit falsifiability conditions in Section 8 are a notable strength, distinguishing this proposal from unfalsifiable visions. The readiness ladder (mentioned → interpreted → actionable → executable) usefully separates representational status from operational lifecycle. The companion feasibility study, although narrow, provides an existence proof for one subproblem. If the framework gains traction, it could help align clinical NLP research with downstream workflow execution, potentially reducing loop-closure failures that the paper documents. These strengths are real, and the stated scope is appropriately careful.

major comments (2)
  1. [Section 5.1 and Section 7] The central claim that Layer 3 makes patient-specific clinical intent computable requires a precise criterion for when a recovered ACR faithfully represents the clinician's intended action. Definition 1 specifies the tuple's attributes but does not define what constitutes faithful recovery; the evaluation framework in Section 7 measures action detection, argument extraction, time normalization, and provenance, but none of these measures establishes that executing the recovered ACR would satisfy the original intent. Please add an explicit equivalence criterion—for example, an ACR is correct for a source communication if executing it under the relevant workflow semantics produces the effect the communicator intended—and specify how the proposed evaluation benchmarks are annotated to reflect that criterion (e.g., gold-standard ACRs built by clinicians with adjudication). Without such a criterion, the term 'executable correctness' remains ambiguous and the framework cannot be used to falsify the core claim.
  2. [Section 5.1, Definition 1] The phrase 'populated when communicated or explicitly inferred' is underspecified. It does not state what kinds of inference are permissible or what evidence is required for an attribute to be 'explicitly inferred' rather than guessed. For example, for the actor attribute, can the responsible performer be inferred from the speaker role, from institutional conventions, or only when explicitly mentioned? This boundary directly affects the design of the recovery pipeline and the meaning of the confidence map, which is described only as 'calibrated recovery-system uncertainty.' Please provide an explicit taxonomy of inference types (e.g., from co-reference, from semantic role, from institutional knowledge) and state how calibration is achieved or tested. Without this, the operational semantics of the ACR--and the reader's ability to assess the feasibility evidence--are incomplete.
minor comments (3)
  1. [Section 5.1 vs. Table 1] The 'Class of computation' for Layer 3 in Table 1 is 'Schedule, coordinate, monitor, close,' while Definition 1 in Section 5.1 states that the ACR's attributes are 'required to interpret, execute, monitor, or audit' the action. Please align the wording across these two places so the markers are consistent.
  2. [Reference 49] Reference [49] lists the venue as 'Pac Symp Biocomput 2026;31:144–157' but the DOI (10.1101/2025.08.14.25332837) points to a 2025 preprint server. Please provide the correct publication DOI or update the reference to note the preprint.
  3. [Sections 7–8] Section 8 states that 'moving from synthetic corpora to de-identified real-world notes is the central empirical risk,' but Section 7 describes the companion study [51] only as a 'controlled benchmark.' It is unclear whether that benchmark uses synthetic corpora or real-world notes; please clarify, as this affects the interpretation of the risk statement.

Circularity Check

0 steps flagged · score 0.0 of 10

No circularity found: the third-layer framework is a self-described prospective hypothesis with no fitted inputs, and its only overlapping-author citation is explicitly disclaimed as non-evidence.

full rationale

The paper is a conceptual Perspective, not an empirical derivation. Section 2 defines five markers for a 'computational layer' and applies them retrospectively to layers 1 and 2 and prospectively to layer 3, with the caveat that the third is 'a prospective hypothesis, offered as an analytic lens rather than an established periodization.' Section 5.1 defines the Actionable Clinical Record as a tuple of semantic attributes; this is a representational specification, not a quantity fitted to any subset of data. The claimed capability 'recover it from natural communication' is localized as a gap in Section 4 based on external literature, and Section 8 makes the framework explicitly falsifiable: 'The ACR representation is redundant if direct mapping into existing workflow standards, with generic recovery metadata, captures the required action, actor, temporal, conditional, dependency, provenance, and uncertainty semantics without ACR-specific distinctions.' The only overlapping-author citation is the companion feasibility study [51]; Section 7 explicitly calls it 'a controlled feasibility demonstration for one narrow subproblem, not evidence for the framework, whose value rests on its constructs,' so the self-citation is not load-bearing. The skeptic's concern that equivalence between a recovered ACR and clinician intent is unspecified is a correctness or completeness risk, not circularity: no part of the paper defines the ACR or the framework in terms of that equivalence, and no equation reduces to another. No fitted parameter is renamed as a prediction, no uniqueness theorem is imported from prior author work, and no known result is renamed as a new one. The paper is self-contained as an analytic proposal, so the circularity score is 0.

Assumptions & free parameters 0 free parameters · 3 assumptions · 2 invented entities

The central proposal rests on three unverified premises: recoverability of intent from text, sufficiency of the ACR tuple, and a sharp boundary between existing standards and the proposed recovery capability. No free parameters are fitted in this paper. The ACR and the third layer are invented constructs without an external falsifiable handle supplied in this submission.

assumptions (3)
  • domain assumption Patient-specific clinical intent is expressed in natural clinical communication and is recoverable into structured, executable form.
    Section 4-5 bases the third layer on this premise; Section 8 names real-world notes as the central empirical risk.
  • ad hoc to paper The nine-attribute ACR tuple is sufficient to interpret, execute, monitor, or audit an intended clinical action.
    Definition 1 in Section 5.1 postulates this completeness; no validation or formal semantics are provided.
  • domain assumption Existing standards such as FHIR, computer-interpretable guidelines, and process mining can represent intended process only after it has been structured, but do not recover it from unstructured communication.
    Section 4 and Table 2 use this division to localize the proposed gap; it is an interpretation of the cited literature, not a proven impossibility.
invented entities (2)
  • Actionable Clinical Record (ACR)
    purpose: Atomic representation of a patient-specific intended clinical action, with action, target, actor, temporal constraint, condition, dependency, status, provenance, and confidence, as the unit of the proposed third computational layer.
    Introduced in Definition 1 (Section 5.1); no external implementation or dataset is provided in this paper. The paper assigns it testable predictions, but those predictions are not demonstrated here.
  • Third computational layer of clinical intent
    purpose: A proposed new stratum in healthcare IT whose unit of computability is the intended clinical action, positioned above the record and clinical-state layers.
    Proposed in Sections 1-2 and marked as prospective; it carries no external data or instrument outside the paper, and the authors explicitly call it an analytic lens rather than an established periodization.

how reviews work

0 comments
Cite this review

Pith. "Pith review of Three Generations of Healthcare IT: From the Digital Record to the Computable Care Process." pith.science (2026). https://pith.science/paper/3KY5YT2S

@misc{pith2026260808806,
  author       = {Pith},
  title        = {Pith review of: Three Generations of Healthcare IT: From the Digital Record to the Computable Care Process},
  year         = {2026},
  howpublished = {\url{https://pith.science/paper/3KY5YT2S}},
  note         = {Machine review of arXiv:2608.08806}
}
read the original abstract

Objective. Healthcare IT is usually organized by the technologies it adopts. We instead organize it by the unit of information a system makes computable, and describe a computational layer whose object is patient-specific clinical intent. Approach. We give criteria for a computational layer, derive three (record, clinical state, and a proposed layer of intent), and formalize the Actionable Clinical Record (ACR) as the atomic object of the third layer. Discussion. The framework distinguishes prescribed, observed, and intended process; existing standards represent intent once it is structured but do not recover it from natural communication, the capability we localize. The ACR is complementary to FHIR workflow resources, guidelines, and process mining; a companion feasibility study illustrates tractability for one narrow subproblem. Conclusion. Computable clinical intent is a coherent research direction; the ACR, its readiness ladder, and an executable-correctness evaluation framework are reusable constructs for subsequent work to extend, evaluate, or falsify.

Figures

Figures reproduced from arXiv: 2608.08806 by the authors.

Figure 1
Figure 1. The three computational layers of healthcare IT, organized by the unit of information each makes computable. Layers accumulate rather than replace; layer 3 is proposed. Alt text: three stacked boxes, record at the base, clinical state above it, and clinical intent at the top, with an upward arrow indicating that each layer builds on the one below. Axis Layer 1: Record Layer 2: Clinical state Layer 3: Clinical intent… view at source ↗
Figure 2
Figure 2. The ACR schema. Alt text: nine labeled boxes forming the ACR tuple; action, status, and provenance are shaded to mark them as required; target, actor, temporal constraint, condition, de￾pendency, and confidence are outlined as optional. The third layer spans two distinct axes that together prevent over- and under￾claiming. A representational readiness ladder runs mentioned → interpreted → actiona￾ble → executable: r… view at source ↗
Figure 3
Figure 3. ACRs as the bridge between clinical communication and existing workflow infra￾structure. Alt text: communication sources on the left feed a central clinical-intent layer containing ACR representations, which maps to existing infrastructure such as FHIR resources, schedulers, and referral and results systems on the right. Follow-up is a well-documented case, one of a broader class of communication￾derived process obj… view at source ↗

Discussion (0). Continue with ORCID to comment.

Reference graph

Works this paper leans on

52 extracted references · 31 canonical work pages

  1. [51]

    Reliable Extraction of Clinical Follow -Up Instructions: A Hybrid Neural-Symbolic Pipeline

    Laufer M, Aperstein Y, Apartsin A. Reliable Extraction of Clinical Follow -Up Instructions: A Hybrid Neural-Symbolic Pipeline. arXiv; 2026. arXiv:2605.26560

  2. [1]

    Twenty-Five Years of Evolution and Hurdles in Electronic Health Records and Interoperability in Medical Research: Comprehensive Review

    Shen Y, Yu J, Zhou J, et al. Twenty-Five Years of Evolution and Hurdles in Electronic Health Records and Interoperability in Medical Research: Comprehensive Review. J Med Internet Res 2025;27:e59024. doi:10.2196/59024

  3. [2]

    Electronic Health Records: Then, Now, and in the Future

    Evans RS. Electronic Health Records: Then, Now, and in the Future. Yearb Med Inform 2016;25(Suppl 1):S48–S61. doi:10.15265/IYS-2016-s006

  4. [3]

    Failure to follow -up test results for ambulatory patients: a systematic review

    Callen JL, Westbrook JI, Georgiou A, et al. Failure to follow -up test results for ambulatory patients: a systematic review. J Gen Intern Med 2012;27(10):1334–1348. doi:10.1007/s11606-011-1949-5. 9

  5. [4]

    Closing the Referral Loop: an Analysis of Primary Care Referrals to Specialists in a Large Health System

    Patel MP, Schettini P, O'Leary CP, et al. Closing the Referral Loop: an Analysis of Primary Care Referrals to Specialists in a Large Health System. J Gen Intern Med 2018;33(5):715–721. doi:10.1007/s11606- 018-4392-z

  6. [5]

    Assigning responsibility to close the loop on radiology test results

    Kwan JL, Singh H. Assigning responsibility to close the loop on radiology test results. Diagnosis (Berl) 2017;4(3):173–177. doi:10.1515/dx-2017-0019

  7. [6]

    The frequency of diagnostic errors in outpatient care

    Singh H, Meyer AND, Thomas EJ. The frequency of diagnostic errors in outpatient care. BMJ Qual Saf 2014;23(9):727–731. doi:10.1136/bmjqs-2013-002627

  8. [7]

    The economics of diagnostic safety

    Slawomirski L, Kelly D, de Bienassis K, et al. The economics of diagnostic safety. OECD Health Working Papers 2025. doi:10.1787/fc61057a-en

Show all 52 references
  1. [8]

    Closing the loop on test results to reduce communication failures: a rapid review of evidence, practice and patient perspectives

    Wright B, Lennox A, Graber ML, et al. Closing the loop on test results to reduce communication failures: a rapid review of evidence, practice and patient perspectives. BMC Health Serv Res 2020;20:897. doi:10.1186/s12913-020-05737-x

  2. [9]

    Care Coordination Models and Tools: Systematic Review and Key Informant Interviews

    Duan-Porter W, Ullman K, Majeski B, et al. Care Coordination Models and Tools: Systematic Review and Key Informant Interviews. J Gen Intern Med 2022;37(6):1367–1379. doi:10.1007/s11606-021-07158- w

  3. [10]

    The wisdom hierarchy: representations of the DIKW hierarchy

    Rowley J. The wisdom hierarchy: representations of the DIKW hierarchy. J Inf Sci 2007;33(2):163–180. doi:10.1177/0165551506070706

  4. [11]

    Using Electronic Medical Record Data for Research in a HIMSS Analytics EMRAM Stage 7 Hospital in Beijing: Cross -sectional Study

    Li R, Niu Y, Scott SR, et al. Using Electronic Medical Record Data for Research in a HIMSS Analytics EMRAM Stage 7 Hospital in Beijing: Cross -sectional Study. JMIR Med Inform 2021;9(8):e24405. doi:10.2196/24405

  5. [12]

    Synthesizing Dimensions of Digital Maturity in Hospitals: Systematic Review

    Duncan R, Eden R, Woods L, et al. Synthesizing Dimensions of Digital Maturity in Hospitals: Systematic Review. J Med Internet Res 2022;24(3):e32994. doi:10.2196/32994

  6. [13]

    Meaningful Use

    Blumenthal D, Tavenner M. The “Meaningful Use” Regulation for Electronic Health Records. N Engl J Med 2010;363:501–504. doi:10.1056/NEJMp1006114

  7. [14]

    Electronic Health Record Adoption In US Hospitals: Progress Continues, But Challenges Persist

    Adler-Milstein J, DesRoches CM, Kralovec P, et al. Electronic Health Record Adoption In US Hospitals: Progress Continues, But Challenges Persist. Health Aff 2015;34(12):2174–2180. doi:10.1377/hlthaff.2015.0992

  8. [15]

    Medical Records That Guide and Teach

    Weed LL. Medical Records That Guide and Teach. N Engl J Med 1968;278:593–600. doi:10.1056/NEJM196803212781204

  9. [16]

    Recent Developments in Clinical Terminologies: SNOMED CT, LOINC, and RxNorm

    Bodenreider O, Cornet R, Vreeman DJ. Recent Developments in Clinical Terminologies: SNOMED CT, LOINC, and RxNorm. Yearb Med Inform 2018;27(1):129–139. doi:10.1055/s-0038-1667077

  10. [17]

    HL7 FHIR: An Agile and RESTful Approach to Healthcare Information Exchange

    Bender D, Sartipi K. HL7 FHIR: An Agile and RESTful Approach to Healthcare Information Exchange. IEEE CBMS 2013:326–331. doi:10.1109/CBMS.2013.6627810

  11. [19]

    A general natural -language text processor for clinical ra- diology (MedLEE)

    Friedman C, Alderson PO, Austin JHM, et al. A general natural -language text processor for clinical ra- diology (MedLEE). J Am Med Inform Assoc 1994;1(2):161–174. doi:10.1136/jamia.1994.95236146

  12. [20]

    Mayo clinical Text Analysis and Knowledge Extraction System (cTAKES)

    Savova GK, Masanz JJ, Ogren PV, et al. Mayo clinical Text Analysis and Knowledge Extraction System (cTAKES). J Am Med Inform Assoc 2010;17(5):507–513. doi:10.1136/jamia.2009.001560

  13. [21]

    Toward a National Framework for the Secondary Use of Health Data: An AMIA White Paper

    Safran C, Bloomrosen M, Hammond WE, et al. Toward a National Framework for the Secondary Use of Health Data: An AMIA White Paper. J Am Med Inform Assoc 2007;14(1):1–9. doi:10.1197/ja- mia.M2273. 10

  14. [22]

    Data from clinical notes: a perspective on the tension between structure and flexible documentation

    Rosenbloom ST, Denny JC, Xu H, et al. Data from clinical notes: a perspective on the tension between structure and flexible documentation. J Am Med Inform Assoc 2011;18(2):181–186. doi:10.1136/ja- mia.2010.007237

  15. [23]

    Health Level Seven International; 2023

    HL7 FHIR Release 5: Workflow. Health Level Seven International; 2023. https://hl7.org/fhir/R5/workflow.html (accessed 9 Aug 2026)

  16. [24]

    Computer -interpretable clinical guidelines: a methodological review

    Peleg M. Computer -interpretable clinical guidelines: a methodological review. J Biomed Inform 2013;46(4):744–763. doi:10.1016/j.jbi.2013.06.009

  17. [25]

    IT support for healthcare processes – premises, challenges, perspectives

    Lenz R, Reichert M. IT support for healthcare processes – premises, challenges, perspectives. Data Knowl Eng 2007;61(1):39–58. doi:10.1016/j.datak.2006.04.007

  18. [26]

    Clinical pathway modelling: a literature review

    Aspland E, Gartner D, Harper P. Clinical pathway modelling: a literature review. Health Syst 2021;10(1):1–23. doi:10.1080/20476965.2019.1652547

  19. [27]

    Process Mining: Data Science in Action

    van der Aalst W. Process Mining: Data Science in Action. 2nd ed. Berlin: Springer; 2016. doi:10.1007/978-3-662-49851-4

  20. [28]

    Process mining in healthcare: A literature review

    Rojas E, Munoz-Gama J, Sepúlveda M, et al. Process mining in healthcare: A literature review. J Biomed Inform 2016;61:224–236. doi:10.1016/j.jbi.2016.04.007

  21. [29]

    Overview of the MEDIQA-OE 2025 Shared Task on Medical Order Extraction from Doctor-Patient Consultations

    Corbeil JP, Ben Abacha A, Tremblay J, et al. Overview of the MEDIQA-OE 2025 Shared Task on Medical Order Extraction from Doctor-Patient Consultations. arXiv; 2025. arXiv:2510.26974

  22. [30]

    Real-World Evidence Synthesis of Digital Scribes Using Ambient Listening and Generative Artificial Intelligence for Clinician Documentation Workflows: Rapid Re- view

    Kanaparthy NS, Bakare T, Diao Z, et al. Real-World Evidence Synthesis of Digital Scribes Using Ambient Listening and Generative Artificial Intelligence for Clinician Documentation Workflows: Rapid Re- view. JMIR AI 2025;4:e76743. doi:10.2196/76743

  23. [31]

    CLAMP: a toolkit for efficiently building customized clinical NLP pipe- lines

    Soysal E, Wang J, Jiang M, et al. CLAMP: a toolkit for efficiently building customized clinical NLP pipe- lines. J Am Med Inform Assoc 2018;25(3):331–336. doi:10.1093/jamia/ocx132

  24. [32]

    A text processing pipeline to extract recommendations from radiology reports

    Yetisgen-Yildiz M, Gunn ML, Xia F, et al. A text processing pipeline to extract recommendations from radiology reports. J Biomed Inform 2013;46(2):354–362. doi:10.1016/j.jbi.2012.12.005

  25. [33]

    A scoping review of large language model based approaches for information extraction from radiology reports

    Reichenpfader D, Müller H, Denecke K. A scoping review of large language model based approaches for information extraction from radiology reports. npj Digit Med 2024;7:222. doi:10.1038/s41746-024- 01219-0

  26. [34]

    2018 n2c2 shared task on adverse drug events and medication extraction in electronic health records

    Henry S, Buchan K, Filannino M, et al. 2018 n2c2 shared task on adverse drug events and medication extraction in electronic health records. J Am Med Inform Assoc 2020;27(1):3–12. doi:10.1093/ja- mia/ocz166

  27. [35]

    Large language models are few -shot clinical information ex- tractors

    Agrawal M, Hegselmann S, Lang H, et al. Large language models are few -shot clinical information ex- tractors. Proc. EMNLP 2022:1998–2022. doi:10.18653/v1/2022.emnlp-main.130

  28. [36]

    SemEval -2017 Task 12: Clinical TempEval

    Bethard S, Savova G, Palmer M, et al. SemEval -2017 Task 12: Clinical TempEval. Proc. 11th Int Work- shop Semantic Eval (SemEval-2017) 2017:565–572. doi:10.18653/v1/S17-2093

  29. [37]

    CLIP: A Dataset for Extracting Action Items for Physi- cians from Hospital Discharge Notes

    Mullenbach J, Pruksachatkun Y, Adler S, et al. CLIP: A Dataset for Extracting Action Items for Physi- cians from Hospital Discharge Notes. Proc. 59th Annu Meet Assoc Comput Linguist (ACL -IJCNLP) 2021:1365–1378. doi:10.18653/v1/2021.acl-long.109

  30. [38]

    MedDec: A Dataset for Extracting Medical Decisions from Discharge Summaries

    Elgaar M, Cheng J, Vakil N, et al. MedDec: A Dataset for Extracting Medical Decisions from Discharge Summaries. Findings Assoc Comput Linguist: ACL 2024 2024:16442–16455. doi:10.18653/v1/2024.findings-acl.975

  31. [39]

    Capabilities of GPT -4 on Medical Challenge Problems

    Nori H, King N, McKinney SM, et al. Capabilities of GPT -4 on Medical Challenge Problems. arXiv 2023:2303.13375. 11

  32. [40]

    Survey of Hallucination in Natural Language Generation

    Ji Z, Lee N, Frieske R, et al. Survey of Hallucination in Natural Language Generation. ACM Comput Surv 2023;55(12):248. doi:10.1145/3571730

  33. [41]

    TimeBench: A Comprehensive Evaluation of Temporal Reasoning Abilities in Large Language Models

    Chu Z, Chen J, Chen Q, et al. TimeBench: A Comprehensive Evaluation of Temporal Reasoning Abilities in Large Language Models. Proc. 62nd Annu Meet Assoc Comput Linguist (ACL) 2024:1204–1228. doi:10.18653/v1/2024.acl-long.66

  34. [42]

    Neurosymbolic AI: the 3rd wave

    Garcez A, Lamb LC. Neurosymbolic AI: the 3rd wave. Artif Intell Rev 2023;56:12387–12406. doi:10.1007/s10462-023-10448-w

  35. [43]

    Neuro-symbolic AI for auditable cognitive information extrac- tion from medical reports

    Prenosil GA, Weitzel TK, Bello SC, et al. Neuro-symbolic AI for auditable cognitive information extrac- tion from medical reports. Commun Med 2025;5(1):491. doi:10.1038/s43856-025-01194-x

  36. [44]

    2010 i2b2/VA challenge on concepts, assertions, and relations in clinical text

    Uzuner O, South BR, Shen S, et al. 2010 i2b2/VA challenge on concepts, assertions, and relations in clinical text. J Am Med Inform Assoc 2011;18(5):552–556. doi:10.1136/amiajnl-2011-000203

  37. [45]

    Evaluating temporal relations in clinical text: 2012 i2b2 Challenge

    Sun W, Rumshisky A, Uzuner O. Evaluating temporal relations in clinical text: 2012 i2b2 Challenge. J Am Med Inform Assoc 2013;20(5):806–813. doi:10.1136/amiajnl-2013-001628

  38. [46]

    Multilingual and cross-domain temporal tagging (HeidelTime)

    Strötgen J, Gertz M. Multilingual and cross-domain temporal tagging (HeidelTime). Lang Resour Eval 2013;47(2):269–298. doi:10.1007/s10579-012-9179-y

  39. [47]

    SUTime: A library for recognizing and normalizing time expressions

    Chang AX, Manning CD. SUTime: A library for recognizing and normalizing time expressions. Proc. LREC 2012:3735–3740

  40. [48]

    Multimodal learning for temporal relation extraction in clinical texts

    Knez T, Žitnik S. Multimodal learning for temporal relation extraction in clinical texts. J Am Med In- form Assoc 2024;31(6):1380–1387. doi:10.1093/jamia/ocae059

  41. [49]

    Speaker Role Identification in Clinical Conversations

    Zolensky A, Jang KJ, Sabin J, et al. Speaker Role Identification in Clinical Conversations. Pac Symp Biocomput 2026;31:144–157. doi:10.1101/2025.08.14.25332837

  42. [50]

    Automation bias: a systematic review of frequency, effect mediators, and mitigators

    Goddard K, Roudsari A, Wyatt JC. Automation bias: a systematic review of frequency, effect mediators, and mitigators. J Am Med Inform Assoc 2012;19(1):121–127. doi:10.1136/amiajnl-2011-000089

  43. [52]

    Listening to the note: clinician perspectives on ambient artificial intelligence scribes in medical documentation

    Van Tiem J, Cramer E, Iverson C, et al. Listening to the note: clinician perspectives on ambient artificial intelligence scribes in medical documentation. J Am Med Inform Assoc 2026;33(2):255–262. doi:10.1093/jamia/ocaf214

  44. [53]

    Large language models in real-world clinical workflows: a system- atic review of applications and implementation

    Artsi Y, Sorin V, Glicksberg BS, et al. Large language models in real-world clinical workflows: a system- atic review of applications and implementation. Front Digit Health 2025;7:1659134. doi:10.3389/fdgth.2025.1659134

Pith tools

Reviewed August 14, 2026 · model on record in the stance chip above.