Resting state-fMRI approach towards understanding impairments in mTLE

Mesial temporal lobe epilepsy (mTLE) is the most common form of epilepsy. While it is characterized by an epileptogenic focus in the mesial temporal lobe, it is increasingly understood as a network disorder. Hence, understanding the nature of impairments on a network level is essential for its diagnosis and treatment. In this work, we review recent works that apply resting-state functional MRI to provide key insights into the impairments to the functional architecture in mTLE. We discuss changes on both regional and global scales. Finally, we describe how Machine Learning can be applied to rs-fMRI data to extract resting-state networks specific to mTLE and for automated diagnosis of this disease.