Twelve Decades: Probing the Interstellar Medium from kiloparsec to sub-AU scales

After a decade of great progress in understanding gas flow into, out of, and through the Milky Way, we are poised to merge observations with simulations to build a comprehensive picture of the multi-scale magnetized interstellar medium (ISM). These insights will also be crucial to four bold initiatives in the 2020s: detecting nanohertz gravitational waves with pulsar timing arrays (PTAs), decoding fast radio bursts (FRBs), cosmic B-mode detection, and imaging the Milky Way's black hole with the Event Horizon Telescope (EHT).