Performance Evaluation of Deep Learning and Transformer Models Using Multimodal Data for Breast Cancer Classification

Rising breast cancer (BC) occurrence and mortality are major global concerns for women. Deep learning (DL) has demonstrated superior diagnostic performance in BC classification compared to human expert readers. However, the predominant use of unimodal (digital mammography) features may limit the current performance of diagnostic models. To address this, we collected a novel multimodal dataset comprising both imaging and textual data. This study proposes a multimodal DL architecture for BC classification, utilising images (mammograms; four views) and textual data (radiological reports) from our new in-house dataset. Various augmentation techniques were applied to enhance the training data size for both imaging and textual data. We explored the performance of eleven SOTA DL architectures (VGG16, VGG19, ResNet34, ResNet50, MobileNet-v3, EffNet-b0, EffNet-b1, EffNet-b2, EffNet-b3, EffNet-b7, and Vision Transformer (ViT)) as imaging feature extractors. For textual feature extraction, we utilised either artificial neural networks (ANNs) or long short-term memory (LSTM) networks. The combined imaging and textual features were then inputted into an ANN classifier for BC classification, using the late fusion technique. We evaluated different feature extractor and classifier arrangements. The VGG19 and ANN combinations achieved the highest accuracy of 0.951. For precision, the VGG19 and ANN combination again surpassed other CNN and LSTM, ANN based architectures by achieving a score of 0.95. The best sensitivity score of 0.903 was achieved by the VGG16+LSTM. The highest F1 score of 0.931 was achieved by VGG19+LSTM. Only the VGG16+LSTM achieved the best area under the curve (AUC) of 0.937, with VGG16+LSTM closely following with a 0.929 AUC score.