IntraStyler: Intra-Domain Style Synthesis for Cross-Modality MRI Domain Adaptation

Segmentation of vestibular schwannoma and cochlea from T2 MRI is clinically important yet annotation-intensive. Domain adaptation (DA) has been widely adopted to bridge the gap between labeled contrast-enhanced T1 and unlabeled T2 datasets. While existing methods focus on cross-domain alignment, intra-domain variability within the target domain remains largely overlooked. Images from the same domain may vary substantially due to different scanners, field strengths, and acquisition protocols. Ignoring this variability produces homogeneous synthetic images that limit the generalizability of downstream segmentation models. To address this, we propose IntraStyler, a 3D unpaired image translation method that automatically discovers fine-grained intra-domain styles without any predefined sub-domains, and synthesizes diverse target domain images using per-image style references. To this end, we design a 3D style encoder trained with a novel contrastive learning objective to extract style-only embeddings disentangled from anatomy. IntraStyler is built upon the 1st place CrossMoDA challenge solution and further advances it, generating more diverse synthetic data and achieving more reliable downstream segmentation. Code is available at https://github.com/MedICL-VU/IntraStyler.