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arxiv 1810.08807 v1 pith:LNMEU2AX submitted 2018-10-20 stat.AP

Investigating Voice as a Biomarker for leucine-rich repeat kinase 2-Associated Parkinson's Disease

S. Arora , N.P. Visanji , T.A. Mestre , A. Tsanas , A. AlDakheel , B.S. Connolly , C. Gasca-Salas , D.S. Kern
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J. Jain E.J. Slow A. Faust-Socher A.E. Lang M.A. Little C. Marras
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classification stat.AP
keywords lrrk2-associatedvoicecarrierscontrolsdiseasekinaseleucine-richmean
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We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17 participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, and 26 controls. In distinguishing LRRK2-associated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean specificity was 89.6% (SD 26.5%). Voice features for non-manifesting carriers, related non-carriers, and controls were much less discriminatory. Vocal deficits in LRRK2-associated PD may be different than those in iPD. These preliminary results warrant longitudinal analyses and replication in larger cohorts

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