Effects of local and global network connectivity on synergistic epidemics

The effects of local and global connectivity on the spread of synergistic susceptible-infected-removed epidemics were studied in lattice models with infinite- and finite-range rewiring (small-world and small-world-like models). Several effects were found numerically and supported analytically within a simple model: (i) rewiring enhanced resilience to epidemics with strong constructive synergy on networks with high local connectivity; (ii) rewiring enhanced spread of epidemics with destructive or weak constructive synergy on networks with arbitrary local connectivity; (iii) rewiring enhanced spread of epidemics, independent of synergy, in networks with low local connectivity.