REVIEW 2 major objections 7 minor 76 references
Widest-Path Reachability Fields for Connectivity-Preserving Slender Structure Segmentation
T0 review · 2 major / 7 minor · reviewed 2026-07-09 · glm-5.2
Pith's one-line read Max-Min algebra fixes broken vessel segmentation by targeting
desk verdict Solid practical method with a real gap in the ablation logic — the Max-Min operator itself is never isolated from alternatives. read the letter →
The pith
A machine-rendered reading of the paper's core claim, the machinery that carries it, and where it could break.
The reading
What carries the argument
Differentiable Max-Min dynamic programming over a skeleton-derived support graph. For each source node, the algorithm iteratively propagates reachability values using the recurrence r_{t+1}(v) = max(r_t(v), max_{p} min(r_t(p), w_{pv})), where w_{pv} is the learned edge weight between adjacent nodes. The min operator retains only the bottleneck edge's gradient per candidate path; the max operator selects the strongest path. Ties return a valid subgradient. The support graph is restricted to the ground-truth skeleton domain V* to prevent background shortcuts. Three loss terms are combined: a bottleneck-aware segmentation loss that upweights thin structures via inverse skeleton radius, a local
What would settle it
If replacing the Max-Min operator with a sum-based or product-based reachability formulation on the same domain-restricted support graph produced equivalent clDice improvements, the bottleneck-dominated gradient routing mechanism would not be the operative cause—instead, domain restriction and multi-scale supervision alone would explain the gains.
Extended reading notes
Core claim
The central claim is that connectivity failures in slender-structure segmentation stem not from inadequate model capacity or training data, but from an algebraic property of standard loss functions: sum-based operators spread gradients uniformly, starving the sparse bottleneck pixels that actually determine topological continuity. By replacing the sum operator with a Max-Min operator—where a path's reachability is defined by its weakest edge and the gradient flows only through that bottleneck—training automatically redirects learning signal to the pixels that matter most for connectivity. The differentiable k-step dynamic programming implementation on a domain-restricted support graph makes
Load-bearing premise
The method assumes that a deterministic skeletonization operator applied to the ground-truth binary mask faithfully captures the connectivity structure the network should learn, and that supervising reachability on this coarsened skeleton graph transfers to the full-resolution pixel mask used at inference. If the skeletonization introduces artifacts or the stride-based coarsening loses critical bottleneck topology, the Max-Min gradient routing targets may not align with real
Editorial extensions
If this is right
- Any segmentation task where topology matters more than pixel overlap—neuron tracing, road network extraction, crack detection—could benefit from replacing or augmenting sum-based losses with Max-Min reachability objectives, since the gradient routing mechanism is architecture-agnostic and requires no skeleton labels beyond what is derivable from binary masks.
- The seek-and-repair gradient pattern suggests a natural curriculum: as bottlenecks are progressively strengthened, the network automatically shifts focus, which could reduce or eliminate the need for multi-stage training pipelines or hard-example mining heuristics currently used in vessel and road segmentation.
- The domain-restriction strategy—constraining graph propagation to skeleton-derived support rather than full foreground occupancy—demonstrates that preventing background shortcuts is as important as the Max-Min operator itself, which has implications for any graph-based learning signal where spurious paths could create shortcuts.
- The identification of TGS as a structural property of sum-based losses, rather than a data or capacity problem, reframes connectivity preservation as an optimization geometry question that could be addressed at the loss-function level for many beyond-segmentation tasks involving graph-structured outputs.
Reading between the lines
- The Max-Min gradient routing principle may extend to other domains where a sparse subset of elements determines global property correctness—e.g., chain-of-thought reasoning where one weak logical link breaks an argument, or program synthesis where a single incorrect operation invalidates output—suggesting that bottleneck-dominated gradient flow is a general optimization principle beyond pixel segm
- The 2–3× training time overhead from Max-Min propagation could potentially be reduced by sparse or approximate variants that only propagate through candidate bottleneck regions identified by low-confidence edges, rather than full k-step DP over all nodes, which would make the approach practical for 3D volumetric data where the current formulation may be prohibitively expensive.
- If the skeletonization operator Phi_px introduces systematic biases—e.g., preferentially retaining certain vessel calibers or missing sub-pixel connections—the Max-Min objective would faithfully optimize the wrong connectivity targets, suggesting that sensitivity to skeletonization quality is the critical failure mode that would distinguish between TGS as a fundamental phenomenon versus an artifac
Signed reviews
Editorial analysis
A structured set of objections, weighed in public.
Referee Report
Summary. This paper introduces Widest-Path Reachability Fields (WPRF), a plug-and-play training module for connectivity-preserving segmentation of slender curvilinear structures (vessels, cracks, roads). The authors identify Topological Gradient Starvation (TGS)—the phenomenon where sparse connectivity-critical bottleneck pixels receive insufficient gradients under standard sum-based pixel-wise losses—and propose a differentiable Max-Min reachability objective on a domain-restricted support graph to redirect gradient flow to these bottlenecks. The method is evaluated across nine architectures and six datasets (including a newly introduced oral microvessel dataset, OMVIS) with fixed hyperparameters, showing clDice improvements in 47 of 54 method-dataset pairs. The experimental design is thorough: multiple backbone families, ablations isolating each loss component, gradient routing verification (Fig. 7), and hyperparameter sensitivity analysis.
Significance. The paper addresses a well-known and practically important problem: topological breaks in curvilinear structure segmentation. The TGS formalization provides a clear diagnostic framing, and the Max-Min gradient routing mechanism is a principled solution grounded in classical graph theory (widest-path problem). Key strengths include: (1) the gradient routing verification in Fig. 7, which directly visualizes the shift of gradient energy from thick to thin structures; (2) the breadth of the experimental validation—nine architectures, six datasets, fixed hyperparameters, 9 runs per configuration; (3) the ablation in Table IX isolating edge supervision, reachability supervision, domain restriction, and multi-scale propagation; (4) the plug-and-play, backbone-agnostic design with no inference overhead (Table X). The newly introduced OMVIS dataset with expert annotation and inter-observer agreement reporting is a useful community contribution. Code is stated to be available.
major comments (2)
- The central novelty claim is that Max-Min algebra specifically induces bottleneck-dominated gradient routing (Section III-C, Fig. 3), distinguishing WPRF from prior sum-based and product-based methods (Section II). However, the ablation in Table IX only compares against pixel-level baselines (BCE, Focal, BCE+clDice). It never replaces the Max-Min DP in Eq. (9) with an alternative reachability formulation—e.g., a sum-based additive path cost or a product-based affinity chain—on the same domain-restricted support graph V* with the same multi-scale sampling, edge loss, and BA segmentation term. Without this comparison, the clDice gains cannot be attributed to the Max-Min operator specifically rather than to the general framework of graph-based reachability supervision + domain restriction + multi-scale propagation. The theoretical argument in Section III-C is plausible but not self-evident:
- Dice drops are observed in several configurations (e.g., Swin-UNet on OCTA-500 6mm: 0.801→0.775 in Table V; Swin-UNet on OCTA-500 3mm: 0.828→0.798 in Table IV; CS-Net on OCTA-500 3mm: 0.796→0.788 in Table IV). The paper acknowledges a 'slight Dice drop' in the ablation (Section IV-E) but does not systematically analyze when or why Dice degrades. For a method claiming to preserve connectivity 'without sacrificing region overlap' (Section IV-C), the conditions under which pixel-level overlap significantly decreases should be characterized. Is this a trade-off inherent to the bottleneck-aware weighting (Eq. 12), or does the reachability loss actively suppress certain foreground regions? A brief analysis of the Dice-clDice trade-off space would strengthen the paper.
minor comments (7)
- Section III-B, Eq. (2): the deterministic skeletonization operator Phi_px is described as 'closing (3x3) + Zhang-Suen thinning' in Table I but the text mentions 'lightweight morphological preprocessing to fill small gaps.' The sensitivity of the support graph V* to the choice of skeletonization algorithm is not discussed. A brief note on robustness to skeletonization quality would strengthen the paper.
- Table I states 'Augmentation: None.' For a method evaluated across six datasets with varying characteristics, the absence of any data augmentation is unusual and may disadvantage baselines. A brief justification for this choice would be helpful.
- Section IV-F.3, Table X: training time increases by 2-3x with WPRF (e.g., UNet on DRIVE: 9.7→79.7 ms/iter). While the paper notes this is training-only overhead, the practical implications for large-scale experiments are not discussed. The paper mentions 'sparse Max-Min propagation' as future work but does not quantify how much overhead could be reduced.
- Fig. 4: the y-axis label 'ΔclDice (pp)' and the markers are clear, but the 'dataset min-max' whiskers overlap with individual backbone markers in some cases, making it difficult to distinguish per-backbone values from the range. Consider jittering or using a different visual encoding.
- Section III-D, Eq. (10): the positive pair distance criterion dist ∈ [ceil(k/2), k] is motivated as excluding 'trivially reachable pairs,' but the choice of ceil(k/2) as the lower bound is not justified. Is this sensitive to the choice of lower bound?
- The paper introduces the term 'Bottleneck-Aware Balanced Hard-Negative BCE' for L_seg (Section III-D) but the 'bottleneck-aware' aspect refers to the weight W-bar(x) based on skeleton radius (Eq. 12), which is conceptually distinct from the Max-Min bottleneck routing in L_reach. The shared use of 'bottleneck' terminology for both the pixel-level reweighting and the graph-level Max-Min routing may cause confusion. Clarifying the relationship between the two mechanisms would help.
- Reference formatting: some entries have inconsistent capitalization and venue abbreviations (e.g., 'arXiv preprint' vs. full conference names). A pass through the reference list for consistency would improve presentation.
Circularity Check
No circularity found; derivation is self-contained against external benchmarks and classical graph theory
full rationale
The paper's derivation chain is not circular. (1) The TGS concept is an analogy to gradient starvation in classification (ref 18, Pezeshki et al., NeurIPS 2021 — external), not a self-cited result. (2) The Max-Min widest-path formulation derives from classical graph theory (refs 59–60, Smith 1993; Udupa & Samarasekera 1996 — external), and the k-step DP in Eq. (9) is a standard Max-Min semiring computation. (3) The gradient routing property (Section III-C) is an inherent mathematical property of min/max operators, not defined in terms of the paper's own outputs. (4) The support graph V* (Eq. 2) is constructed from GT masks via deterministic operators, not from predictions. (5) The bottleneck-aware weight (Eq. 12) is derived from skeleton radius of GT, not from the model's own predictions. (6) Pair labels for reachability supervision (Eq. 10) come from GT connected-component structure, not from predicted affinities. (7) Self-citations (refs 9, 24, 33) are tangential — a SAM2 case study, a manufacturing random forest, and a meta-contrastive learning model — none are invoked as load-bearing mathematical results or uniqueness theorems. (8) The OMVIS dataset is independently collected with ethical approval and inter-observer validation. (9) Experimental validation uses external datasets (DRIVE, OCTA-500, DeepCrack, Massachusetts Roads) and standard metrics (Dice, clDice). The skeptic's concern about Max-Min not being ablated against sum/product alternatives on the same graph is a valid experimental completeness concern, but it is a correctness/evaluation risk, not circularity — the paper does not define its prediction in terms of its own inputs or self-cited unverified results.
Assumptions & free parameters
free parameters (7)
- lambda_edge =
1.0
- lambda_reach =
1.0
- graph stride s =
4
- N_s (sources per image) =
32
- multi-scale steps K =
{1,2,4,8,16}
- tau_fg, tau_link =
0.5, 0.5
- epsilon =
1e-6
assumptions (4)
- domain assumption Threshold-based connectivity criterion: two points are reachable if there exists a path whose edge weights all exceed a threshold.
- domain assumption The deterministic skeleton Phi_px faithfully represents the connectivity structure of the union foreground.
- domain assumption Max-Min subgradient propagation through k-step DP provides a valid and sufficient training signal for connectivity.
- domain assumption Bottleneck pixels are the primary cause of topological breaks in slender structure segmentation.
invented entities (3)
-
Topological Gradient Starvation (TGS)
independent evidence
-
Widest-Path Reachability Fields (WPRF)
independent evidence
-
OMVIS dataset
independent evidence
Cite this review
Pith. "Pith review of Widest-Path Reachability Fields for Connectivity-Preserving Slender Structure Segmentation." pith.science (2026). https://pith.science/paper/P5E4UPU6
@misc{pith2026260707123,
author = {Pith},
title = {Pith review of: Widest-Path Reachability Fields for Connectivity-Preserving Slender Structure Segmentation},
year = {2026},
howpublished = {\url{https://pith.science/paper/P5E4UPU6}},
note = {Machine review of arXiv:2607.07123}
}
read the original abstract
Segmenting slender curvilinear structures such as retinal vessels, cracks, and roads demands topological correctness, as even a single-pixel discontinuity can fragment a continuous network and invalidate downstream analysis. Under standard binary-mask supervision, models optimized for pixel-level overlap frequently produce topologically broken predictions. We trace this to a fundamental mismatch: pixel-wise losses distribute gradients uniformly, yet connectivity hinges on a sparse set of bottleneck pixels. These pixels are vastly outnumbered by thick structures and background, rendering their aggregate gradient contribution negligible. We term this phenomenon topological gradient starvation (TGS). To address it, we propose Widest-Path Reachability Fields (WPRF), a differentiable Max-Min reachability objective that redirects gradient flow to connectivity bottlenecks. The module is plug-and-play, backbone-agnostic, and incurs no inference overhead. WPRF implements a differentiable Max-Min objective via dynamic programming on a domain-restricted graph, coupled with a bottleneck-aware observation term that balances gradient contributions across varying structures. Compared to prior topology-aware losses that rely on post-hoc skeletonization or homology computation, WPRF directly optimizes end-to-end reachability via differentiable Max-Min algebra, enabling gradient flow to concentrate on connectivity bottlenecks without auxiliary structures. We introduce OMVIS, a new oral microvessel segmentation dataset. Experiments across nine architectures and six datasets validate the bottleneck-focused gradient routing mechanism. WPRF improves 87\% of experiments with fixed hyperparameters and achieves clDice gains of 7.2 percentage points on structurally fragile datasets.
Figures
Figures from the paper (4 more)
Reference graph
Works this paper leans on
-
[1]
An anatomy- and topology-preserving frame- work for coronary artery segmentation,
X. Zhang, K. Sun, D. Wu, X. Xiong, J. Liu, L. Yao, S. Li, Y . Wang, J. Feng, and D. Shen, “An anatomy- and topology-preserving frame- work for coronary artery segmentation,”IEEE Transactions on Medical Imaging, vol. 43, no. 2, pp. 723–733, Feb 2024
work page 2024
-
[2]
Z. Sun, H. Wang, Q. Xie, Y . Zheng, and D. Meng, “RSF-Conv: Rotation-and-scale equivariant Fourier parameterized convolution for retinal vessel segmentation,”IEEE Transactions on Neural Networks and Learning Systems, vol. 36, no. 9, pp. 16 549–16 563, September 2025. [Online]. Available: https://doi.org/10.1109/TNNLS.2025.3560082
-
[3]
Topology-guided road graph extraction from remote sensing images,
Y . Zao, Z. Zou, and Z. Shi, “Topology-guided road graph extraction from remote sensing images,”IEEE Transactions on Geoscience and Remote Sensing, vol. 62, pp. 1–14, 2024
work page 2024
-
[4]
Universal vessel segmentation for multi- modality retinal images,
B. Wen, A. Heinke, A. Agnihotri, D.-U. Bartsch, W. Freeman, T. Nguyen, and C. An, “Universal vessel segmentation for multi- modality retinal images,”IEEE Transactions on Image Processing, vol. 34, pp. 7903–7918, 2025. [Online]. Available: https://doi.org/10. 1109/TIP.2025.3623893
-
[5]
Aerial images meet crowdsourced trajectories: A new approach to robust road extraction,
L. Liu, Z. Yang, G. Li, K. Wang, T. Chen, and L. Lin, “Aerial images meet crowdsourced trajectories: A new approach to robust road extraction,”IEEE Transactions on Neural Networks and Learning PREPRINT, JULY 2026 12 Systems, vol. 34, no. 7, pp. 3308–3322, July 2023. [Online]. Available: https://doi.org/10.1109/TNNLS.2022.3141821
-
[6]
Context enhancing representation for semantic segmentation in remote sensing images,
L. Fang, P. Zhou, X. Liu, P. Ghamisi, and S. Chen, “Context enhancing representation for semantic segmentation in remote sensing images,” IEEE Transactions on Neural Networks and Learning Systems, vol. 35, no. 3, pp. 4138–4152, March 2024. [Online]. Available: https://doi.org/10.1109/TNNLS.2022.3201820
-
[7]
W. Zhou, J. Xie, and C. Xu, “Semantic prompt and graph- convolution-structure distillation framework for semantic segmentation of remote sensing images,”IEEE Transactions on Neural Networks and Learning Systems, pp. 1–14, 2026. [Online]. Available: https: //doi.org/10.1109/TNNLS.2026.3675381
-
[8]
Sam 2: Segment anything in images and videos,
N. Ravi, V . Gabeur, Y .-T. Hu, R. Hu, C. Ryali, T. Ma, H. Khedr, R. R ¨adle, C. Rolland, L. Gustafson, E. Mintun, J. Pan, K. V . Alwala, N. Carion, C.-Y . Wu, R. Girshick, P. Dollar, and C. Feichtenhofer, “Sam 2: Segment anything in images and videos,” inInternational Conference on Learning Representations, Y . Yue, A. Garg, N. Peng, F. Sha, and R. Yu, E...
work page 2025
Show all 76 references
-
[9]
Zero-shot capillary segmentation in dermoscopy images via sam2: A case study on oral mucosa,
W. Su, Y . Zong, R. Jia, J. Qin, and M. Li, “Zero-shot capillary segmentation in dermoscopy images via sam2: A case study on oral mucosa,”IEEE Journal of Biomedical and Health Informatics, pp. 1– 12, 2025
2025
-
[10]
Coarse-to-fine semantic segmentation from image-level labels,
L. Jing, Y . Chen, and Y . Tian, “Coarse-to-fine semantic segmentation from image-level labels,”IEEE Transactions on Image Processing, vol. 29, pp. 225–236, 2020. [Online]. Available: https://doi.org/10.1109/ TIP.2019.2926748
2020
-
[11]
Spatial structure constraints for weakly supervised semantic segmentation,
T. Chen, Y . Yao, X. Huang, Z. Li, L. Nie, and J. Tang, “Spatial structure constraints for weakly supervised semantic segmentation,” IEEE Transactions on Image Processing, vol. 33, pp. 1136–1148, 2024. [Online]. Available: https://doi.org/10.1109/TIP.2024.3359041
2024 doi
-
[12]
Guided filter network for semantic image segmentation,
X. Zhang, W. Zhao, W. Zhang, J. Peng, and J. Fan, “Guided filter network for semantic image segmentation,”IEEE Transactions on Image Processing, vol. 31, pp. 2695–2709, 2022. [Online]. Available: https://doi.org/10.1109/TIP.2022.3160399
2022 doi
-
[13]
Double similarity distillation for semantic image segmentation,
Y . Feng, X. Sun, W. Diao, J. Li, and X. Gao, “Double similarity distillation for semantic image segmentation,”IEEE Transactions on Image Processing, vol. 30, pp. 5363–5376, 2021. [Online]. Available: https://doi.org/10.1109/TIP.2021.3083113
2021 doi
-
[14]
Geometric boundary guided feature fusion and spatial-semantic context aggregation for semantic segmentation of remote sensing images,
Y . Wang, H. Zhang, Y . Hu, X. Hu, L. Chen, and S. Hu, “Geometric boundary guided feature fusion and spatial-semantic context aggregation for semantic segmentation of remote sensing images,” IEEE Transactions on Image Processing, vol. 32, pp. 6373–6385, 2023. [Online]. Availab...
2023 doi
-
[15]
Fuzzy attention neural network to tackle discontinuity in airway segmentation,
Y . Nan, J. Del Ser, Z. Tang, P. Tang, X. Xing, Y . Fang, F. Herrera, W. Pedrycz, S. Walsh, and G. Yang, “Fuzzy attention neural network to tackle discontinuity in airway segmentation,” IEEE Transactions on Neural Networks and Learning Systems, vol. 35, no. 6, pp. 7391–7404, J...
2024 doi
-
[16]
Dynamic snake convolution based on topological geometric constraints for tubular structure segmentation,
Y . Qi, Y . He, X. Qi, Y . Zhang, and G. Yang, “Dynamic snake convolution based on topological geometric constraints for tubular structure segmentation,” in2023 IEEE/CVF International Conference on Computer Vision (ICCV), October 2023, pp. 6047–6056. [Online]. Available: https...
2023
-
[17]
Skeleton recall loss for connectivity conserving and resource efficient segmentation of thin tubular structures,
Y . Kirchhoff, M. R. Rokuss, S. Roy, B. Kovacs, C. Ulrich, T. Wald, M. Zenk, P. V ollmuth, J. Kleesiek, F. Isensee, and K. Maier-Hein, “Skeleton recall loss for connectivity conserving and resource efficient segmentation of thin tubular structures,” inComputer Vision – ECCV 20...
2024 doi
-
[18]
Gradient starvation: A learning proclivity in neural networks,
M. Pezeshki, O. Kaba, Y . Bengio, A. C. Courville, D. Precup, and G. Lajoie, “Gradient starvation: A learning proclivity in neural networks,” inAdvances in Neural Information Processing Systems, M. Ranzato, A. Beygelzimer, Y . Dauphin, P. Liang, and J. W. Vaughan, Eds., vol. 3...
2021
-
[19]
Available: https://proceedings.neurips.cc/paper files/ paper/2021/file/0987b8b338d6c90bbedd8631bc499221-Paper.pdf
[Online]. Available: https://proceedings.neurips.cc/paper files/ paper/2021/file/0987b8b338d6c90bbedd8631bc499221-Paper.pdf
2021
-
[20]
U-net: Convolutional networks for biomedical image segmentation,
O. Ronneberger, P. Fischer, and T. Brox, “U-net: Convolutional networks for biomedical image segmentation,” inMedical Image Computing and Computer-Assisted Intervention – MICCAI 2015, N. Navab, J. Horneg- ger, W. M. Wells, and A. F. Frangi, Eds. Cham: Springer International Pu...
2015
-
[21]
FANet: A feedback attention network for improved biomedical image segmentation,
N. K. Tomar, D. Jha, M. A. Riegler, H. D. Johansen, D. Johansen, J. Rittscher, P. Halvorsen, and S. Ali, “FANet: A feedback attention network for improved biomedical image segmentation,” IEEE Transactions on Neural Networks and Learning Systems, vol. 34, no. 11, pp. 9375–9388,...
2023 doi
-
[22]
SwinPA-Net: Swin transformer-based multiscale feature pyramid aggregation network for medical image segmentation,
H. Du, J. Wang, M. Liu, Y . Wang, and E. Meijering, “SwinPA-Net: Swin transformer-based multiscale feature pyramid aggregation network for medical image segmentation,”IEEE Transactions on Neural Networks and Learning Systems, vol. 35, no. 4, pp. 5355–5366, April 2024. [Online]...
2024 doi
-
[23]
Equalization loss for long-tailed object recognition,
J. Tan, C. Wang, B. Li, Q. Li, W. Ouyang, C. Yin, and J. Yan, “Equalization loss for long-tailed object recognition,” in2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), June 2020, pp. 11 659–11 668. [Online]. Available: https: //openaccess.thecvf.com...
2020
-
[24]
Polyloss: A polynomial expansion perspective of classification loss functions,
Z. Leng, M. Tan, C. Liu, E. D. Cubuk, J. Shi, S. Cheng, and D. Anguelov, “Polyloss: A polynomial expansion perspective of classification loss functions,” inInternational Conference on Learning Representations, 2022. [Online]. Available: https://openreview.net/ forum?id=gSdSJoenupI
2022
-
[25]
Hybrid grid search and bayesian optimization-based random forest regression for predicting material compression pressure in manufacturing processes,
Y . Zong, Y . Nian, C. Zhang, X. Tang, L. Wang, and L. Zhang, “Hybrid grid search and bayesian optimization-based random forest regression for predicting material compression pressure in manufacturing processes,”Engineering Applications of Artificial Intelligence, vol. 141, p....
2025
-
[26]
Global minimum for active contour models: A minimal path approach,
L. D. Cohen and R. Kimmel, “Global minimum for active contour models: A minimal path approach,”International journal of computer vision, vol. 24, no. 1, pp. 57–78, aug 1997. [Online]. Available: https://doi.org/10.1023/A:1007922224810
1997 doi
-
[27]
Cape: Connectivity-aware path enforcement loss for curvilinear structure delineation,
E. Esmaeilzadeh, E. Garaaghaji, F. Hallaji Azad, and D. Oner, “Cape: Connectivity-aware path enforcement loss for curvilinear structure delineation,” inMedical Image Computing and Computer Assisted Intervention – MICCAI 2025, J. C. Gee, D. C. Alexander, J. Hong, J. E. Iglesias...
2025
-
[28]
Available: https://doi.org/10.1007/978-3-032-05162-2 18
[Online]. Available: https://doi.org/10.1007/978-3-032-05162-2 18
-
[29]
Capturing graphs with hypo-elliptic diffusions,
C. Toth, D. Lee, C. Hacker, and H. Oberhauser, “Capturing graphs with hypo-elliptic diffusions,” inAdvances in Neural Information Processing Systems, S. Koyejo, S. Mohamed, A. Agarwal, D. Belgrave, K. Cho, and A. Oh, Eds., vol. 35. Curran Associates, Inc., 2022, pp. 38 803–38 ...
2022
-
[30]
Random walks for image segmentation,
L. Grady, “Random walks for image segmentation,”IEEE Transactions on Pattern Analysis and Machine Intelligence, vol. 28, no. 11, pp. 1768– 1783, Nov 2006
2006
-
[31]
Normalized cuts and image segmentation,
J. Shi and J. Malik, “Normalized cuts and image segmentation,”IEEE Transactions on Pattern Analysis and Machine Intelligence, vol. 22, no. 8, pp. 888–905, Aug 2000
2000
-
[32]
Tokencut: Segmenting objects in images and videos with self-supervised transformer and normalized cut,
Y . Wang, X. Shen, Y . Yuan, Y . Du, M. Li, S. X. Hu, J. L. Crowley, and D. Vaufreydaz, “Tokencut: Segmenting objects in images and videos with self-supervised transformer and normalized cut,”IEEE Transactions on Pattern Analysis and Machine Intelligence, vol. 45, no. 12, pp. ...
2023
-
[33]
Cross-dimension affinity distillation for 3d em neuron segmentation,
X. Liu, M. Cai, Y . Chen, Y . Zhang, T. Shi, R. Zhang, X. Chen, and Z. Xiong, “Cross-dimension affinity distillation for 3d em neuron segmentation,” in2024 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR). Los Alamitos, CA, USA: IEEE Computer Society, Jun ...
2024 doi
-
[34]
Efficient neuron segmentation in electron microscopy by affinity-guided queries,
H. Chen, C. Tang, X. Li, and X. Hu, “Efficient neuron segmentation in electron microscopy by affinity-guided queries,” inThe Thirteenth International Conference on Learning Representations, 2025. [Online]. Available: https://openreview.net/forum?id=Y0QqruhqIa
2025
-
[35]
A meta- contrastive learning hybrid model for adaptive temperature trend prediction in variable ladle preheating,
Y . Zong, R. Jia, S. Wu, L. Zhang, and D. He, “A meta- contrastive learning hybrid model for adaptive temperature trend prediction in variable ladle preheating,”Engineering Applications of Artificial Intelligence, vol. 162, p. 112750, 2025. [Online]. Available: https://www.sci...
2025
-
[36]
On vanishing gradients, over-smoothing, and over-squashing in GNNs: Bridging recurrent and graph learning,
´Alvaro Arroyo, A. Gravina, B. Gutteridge, F. Barbero, C. Gallicchio, X. Dong, M. Bronstein, and P. Vandergheynst, “On vanishing gradients, over-smoothing, and over-squashing in GNNs: Bridging recurrent and graph learning,”arXiv preprint arXiv:2502.10818, 2025. [Online]. Avail...
2025
-
[37]
Sagman: Stability analysis of graph neural networks on the manifolds,
W. Cheng, C. Deng, A. Aghdaei, Z. Zhang, and Z. Feng, “Sagman: Stability analysis of graph neural networks on the manifolds,” The Thirteenth International Conference on Learning Representations (ICLR), 2024. [Online]. Available: https://openreview.net/forum?id= mVExccNdtK3
2024
-
[38]
Semi-supervised segmentation of histopathology images with noise-aware topological consistency,
M. Xu, X. Hu, S. Gupta, S. Abousamra, and C. Chen, “Semi-supervised segmentation of histopathology images with noise-aware topological consistency,” inComputer Vision – ECCV 2024, A. Leonardis, E. Ricci, S. Roth, O. Russakovsky, T. Sattler, and G. Varol, Eds. Cham: Springer Na...
2024 doi
-
[40]
Anatomically plausible segmentations: Explicitly preserving topology through prior deformations,
M. K. Wyburd, N. K. Dinsdale, M. Jenkinson, and A. I. Namburete, “Anatomically plausible segmentations: Explicitly preserving topology through prior deformations,”Medical Image Analysis, vol. 97, p. 103222, July 2024. [Online]. Available: https://www.sciencedirect.com/ science...
2024
-
[42]
Centerline boundary dice loss for vascular segmentation,
P. Shi, J. Hu, Y . Yang, Z. Gao, W. Liu, and T. Ma, “Centerline boundary dice loss for vascular segmentation,” inMedical Image Computing and Computer Assisted Intervention – MICCAI 2024, M. G. Linguraru, Q. Dou, A. Feragen, S. Giannarou, B. Glocker, K. Lekadir, and J. A. Schna...
2024 doi
-
[43]
Self-supervised 3d skeleton completion for vascular structures,
J. Ren, Z. Li, W. Cheng, Z. Zou, K. Park, Y . Pan, and H. Ling, “Self-supervised 3d skeleton completion for vascular structures,” inMedical Image Computing and Computer Assisted Intervention – MICCAI 2024, M. G. Linguraru, Q. Dou, A. Feragen, S. Giannarou, B. Glocker, K. Lekad...
2024 doi
-
[44]
Glcp: Global-to-local connectivity preservation for tubular structure segmentation,
F. Zhou, Z. Gao, H. Zhao, J. Xie, Y . Meng, Y . Zhao, G. Y . H. Lip, and Y . Zheng, “Glcp: Global-to-local connectivity preservation for tubular structure segmentation,” inMedical Image Computing and Computer Assisted Intervention – MICCAI 2025, J. C. Gee, D. C. Alexander, J. ...
2025 doi
-
[45]
Netracer: A topology-aware iterative tracing approach for tubular structure extraction,
C. Liu, Y . Jiang, and N. Zheng, “Netracer: A topology-aware iterative tracing approach for tubular structure extraction,” inProceedings of the IEEE/CVF International Conference on Computer Vision (ICCV), October 2025, pp. 20 593–20 602
2025
-
[46]
Curvi-tracker: Curvilinear structure segmentation refinement by iterative tracking,
Z. Heng, M. Pagnucco, E. Meijering, and Y . Song, “Curvi-tracker: Curvilinear structure segmentation refinement by iterative tracking,” Pattern Recognition, vol. 173, p. 112797, May 2026. [Online]. Available: https://www.sciencedirect.com/science/article/pii/S0031320325014608
2026
-
[47]
Boundary-aware axial attention network for high-quality pavement crack detection,
K. Wu, B. Peng, and D. Zhai, “Boundary-aware axial attention network for high-quality pavement crack detection,”IEEE Transactions on Neural Networks and Learning Systems, vol. 36, no. 7, pp. 13 555–13 566, July 2025. [Online]. Available: https://doi.org/10.1109/ TNNLS.2024.3497145
2025
-
[48]
A deeply supervised convolutional neural network for pavement crack detection with multiscale feature fusion,
Z. Qu, C. Cao, L. Liu, and D.-Y . Zhou, “A deeply supervised convolutional neural network for pavement crack detection with multiscale feature fusion,”IEEE Transactions on Neural Networks and Learning Systems, vol. 33, no. 9, pp. 4890–4899, September 2022. [Online]. Available:...
2022 doi
-
[49]
Representing topological self-similarity using fractal feature maps for accurate segmentation of tubular structures,
J. Huang, Y . Zhou, Y . Luo, G. Liu, H. Guo, and G. Yang, “Representing topological self-similarity using fractal feature maps for accurate segmentation of tubular structures,” inComputer Vision – ECCV 2024, A. Leonardis, E. Ricci, S. Roth, O. Russakovsky, T. Sattler, and G. V...
2024
-
[50]
Available: https://doi.org/10.1007/978-3-031-73404-5 9
[Online]. Available: https://doi.org/10.1007/978-3-031-73404-5 9
-
[51]
Harmonyseg: Tubular structure segmentation with deep-shallow feature fusion and growth-suppression balanced loss,
Y . Huang, K. Zhang, W. Liu, Y . Wang, V . M. Patel, L. Lu, X. Han, D. Jin, and K. Yan, “Harmonyseg: Tubular structure segmentation with deep-shallow feature fusion and growth-suppression balanced loss,” inProceedings of the IEEE/CVF International Conference on Computer Vision...
2025
-
[52]
Vesselsdf: Distance field priors for vascular network reconstruction,
S. Esposito, D. Rebain, A. Onken, C. Li, and O. Mac Aodha, “Vesselsdf: Distance field priors for vascular network reconstruction,” inMedical Image Computing and Computer Assisted Intervention – MICCAI 2025, J. C. Gee, D. C. Alexander, J. Hong, J. E. Iglesias, C. H. Sudre, A. V...
2025 doi
-
[53]
A topology-preserving three-stage framework for fully-connected coronary artery extraction,
Y . Qiu, D. Shan, Y . Wang, P. Dong, D. Wu, X. Yang, Q. Hong, and D. Shen, “A topology-preserving three-stage framework for fully-connected coronary artery extraction,”Medical Image Analysis, vol. 103, p. 103578, July 2025. [Online]. Available: https://www. sciencedirect.com/s...
2025
-
[54]
Topotta: Topology-enhanced test-time adaptation for tubular structure segmentation,
J. Zhou, W. Wang, S. Li, X. Qu, X. Guo, Y . Liu, W. Tang, X. Lin, and Y . Zheng, “Topotta: Topology-enhanced test-time adaptation for tubular structure segmentation,” inProceedings of the IEEE/CVF International Conference on Computer Vision (ICCV). IEEE, October 2025, pp. 24 1...
2025
-
[55]
cldice - a novel topology- preserving loss function for tubular structure segmentation,
S. Shit, J. C. Paetzold, A. Sekuboyina, I. Ezhov, A. Unger, A. Zhylka, J. P. W. Pluim, U. Bauer, and B. H. Menze, “cldice - a novel topology- preserving loss function for tubular structure segmentation,” in2021 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CV...
2021
-
[56]
A topological loss function for deep-learning based image segmentation using persistent homology,
J. R. Clough, N. Byrne, I. Oksuz, V . A. Zimmer, J. A. Schnabel, and A. P. King, “A topological loss function for deep-learning based image segmentation using persistent homology,”IEEE Transactions on Pattern Analysis and Machine Intelligence, vol. 44, no. 12, pp. 8766–8778, dec
-
[57]
Available: https://doi.org/10.1109/TPAMI.2020.3013679
[Online]. Available: https://doi.org/10.1109/TPAMI.2020.3013679
2020 doi
-
[58]
Topology-aware focal loss for 3d image segmentation,
A. Demir, E. Massaad, and B. Kiziltan, “Topology-aware focal loss for 3d image segmentation,” in2023 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW). IEEE, June 2023, pp. 580–589. [Online]. Available: https://doi.org/10.1109/ CVPRW59228.2023.00065
2023
-
[59]
Topology-preserving image segmentation with spatial-aware persistent feature matching,
B. Wen, H. Zhang, D.-U. G. Bartsch, W. Freeman, T. Nguyen, and C. An, “Topology-preserving image segmentation with spatial-aware persistent feature matching,” inProceedings of the IEEE/CVF Inter- national Conference on Computer Vision (ICCV) Workshops, October 2025, pp. 5762–5771
2025
-
[60]
Deep closing: Enhancing topological connectivity in medical tubular segmentation,
Q. Wu, Y . Chen, W. Liu, X. Yue, and X. Zhuang, “Deep closing: Enhancing topological connectivity in medical tubular segmentation,” IEEE Transactions on Medical Imaging, vol. 43, no. 11, pp. 3990–4003, 2024
2024
-
[61]
Topology optimization in medical image segmentation with fastχeuler characteristic,
L. Li, Q. Ma, C. Ouyang, J. C. Paetzold, D. Rueckert, and B. Kainz, “Topology optimization in medical image segmentation with fastχeuler characteristic,”IEEE Transactions on Medical Imaging, vol. 44, no. 12, pp. 5221–5232, April 2025
2025
-
[62]
Topology-preserving downsampling of binary images,
C.-C. Chen and C.-H. Peng, “Topology-preserving downsampling of binary images,” inComputer Vision – ECCV 2024, A. Leonardis, E. Ricci, S. Roth, O. Russakovsky, T. Sattler, and G. Varol, Eds. Cham: Springer Nature Switzerland, 2025, pp. 416–431. [Online]. Available: https://doi...
2024 doi
-
[63]
D. K. Smith,Network Flows: Theory, Algorithms, and Applications. Englewood Cliffs, NJ: Prentice Hall, 1993, vol. 45
1993
-
[64]
Fuzzy connectedness and object definition: Theory, algorithms, and applications in image segmentation,
J. K. Udupa and S. Samarasekera, “Fuzzy connectedness and object definition: Theory, algorithms, and applications in image segmentation,” Graphical Models and Image Processing, vol. 58, no. 3, pp. 246–261, May 1996. [Online]. Available: https://www.sciencedirect.com/science/ a...
1996
-
[65]
Ridge-based vessel segmentation in color images of the retina,
J. Staal, M. Abramoff, M. Niemeijer, M. Viergever, and B. van Ginneken, “Ridge-based vessel segmentation in color images of the retina,”IEEE Transactions on Medical Imaging, vol. 23, no. 4, pp. 501–509, 2004. [Online]. Available: https://doi.org/10.1109/TMI.2004. 825627
2004 doi
-
[66]
Octa-500: A retinal dataset for optical coherence tomography angiography study,
M. Li, K. Huang, Q. Xu, J. Yang, Y . Zhang, Z. Ji, K. Xie, S. Yuan, Q. Liu, and Q. Chen, “Octa-500: A retinal dataset for optical coherence tomography angiography study,”Medical Image Analysis, vol. 93, p. 103092, 2024. [Online]. Available: https://www.sciencedirect.com/scienc...
2024
-
[67]
Deepcrack: Learning hierarchical convolutional features for crack detection,
Q. Zou, Z. Zhang, Q. Li, X. Qi, Q. Wang, and S. Wang, “Deepcrack: Learning hierarchical convolutional features for crack detection,”IEEE Transactions on Image Processing, vol. 28, no. 3, pp. 1498–1512,
-
[68]
Available: https://doi.org/10.1109/TIP.2018.2878966
[Online]. Available: https://doi.org/10.1109/TIP.2018.2878966
2018 doi
-
[69]
Learning to detect roads in high- resolution aerial images,
V . Mnih and G. E. Hinton, “Learning to detect roads in high- resolution aerial images,” inComputer Vision – ECCV 2010, K. Daniilidis, P. Maragos, and N. Paragios, Eds. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010, pp. 210–223. [Online]. Available: https://doi.org/10.1...
2010 doi
-
[70]
Encoder-decoder with atrous separable convolution for semantic image segmentation,
L.-C. Chen, Y . Zhu, G. Papandreou, F. Schroff, and H. Adam, “Encoder-decoder with atrous separable convolution for semantic image segmentation,” inComputer Vision – ECCV 2018, V . Ferrari, M. Hebert, C. Sminchisescu, and Y . Weiss, Eds. Cham: Springer International Publishing...
2018 doi
-
[71]
Segformer: Simple and efficient design for semantic segmentation with transformers,
E. Xie, W. Wang, Z. Yu, A. Anandkumar, J. M. Alvarez, and P. Luo, “Segformer: Simple and efficient design for semantic segmentation with transformers,” inAdvances in Neural Information Processing Systems, M. Ranzato, A. Beygelzimer, Y . Dauphin, P. Liang, and J. W. Vaughan, Ed...
2021
-
[72]
Masked-attention mask transformer for universal image segmentation,
B. Cheng, I. Misra, A. G. Schwing, A. Kirillov, and R. Girdhar, “Masked-attention mask transformer for universal image segmentation,” in2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR). IEEE, June 2022, pp. 1280–1289. [Online]. Available: https://doi....
2022 doi
-
[73]
Transunet: Rethinking the u-net architecture design for medical image segmentation through the lens of transformers,
J. Chen, J. Mei, X. Li, Y . Lu, Q. Yu, Q. Wei, X. Luo, Y . Xie, E. Adeli, Y . Wang, M. P. Lungren, S. Zhang, L. Xing, L. Lu, A. Yuille, and Y . Zhou, “Transunet: Rethinking the u-net architecture design for medical image segmentation through the lens of transformers,” Medical ...
2024
-
[74]
nnu-net: a self-configuring method for deep learning-based biomedical image segmentation,
F. Isensee, P. F. Jaeger, S. A. A. Kohl, J. Petersen, and K. H. Maier-Hein, “nnu-net: a self-configuring method for deep learning-based biomedical image segmentation,”Nature Methods, vol. 18, no. 2, pp. 203–211,
-
[75]
Available: https://doi.org/10.1038/s41592-020-01008-z
[Online]. Available: https://doi.org/10.1038/s41592-020-01008-z
-
[76]
Cs-net: Channel and spatial attention network for curvilinear structure segmentation,
L. Mou, Y . Zhao, L. Chen, J. Cheng, Z. Gu, H. Hao, H. Qi, Y . Zheng, A. Frangi, and J. Liu, “Cs-net: Channel and spatial attention network for curvilinear structure segmentation,” inMedical Image Computing and Computer Assisted Intervention – MICCAI 2019, D. Shen, T. Liu, T. ...
2019 doi
-
[77]
Swin-unet: Unet-like pure transformer for medical image segmentation,
H. Cao, Y . Wang, J. Chen, D. Jiang, X. Zhang, Q. Tian, and M. Wang, “Swin-unet: Unet-like pure transformer for medical image segmentation,” inComputer Vision – ECCV 2022 Workshops, L. Karlinsky, T. Michaeli, and K. Nishino, Eds. Cham: Springer Nature Switzerland, 2023, pp. 20...
2022 doi
-
[78]
U-mamba: Enhancing long-range dependency for biomedical image segmentation,
J. Ma, F. Li, and B. Wang, “U-mamba: Enhancing long-range dependency for biomedical image segmentation,”arXiv preprint arXiv:2401.04722, 2024. [Online]. Available: https://arxiv.org/abs/2401. 04722
2024 arXiv
Reviewed July 9, 2026 · model on record in the stance chip above.
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