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Metagenome assembly of high-fidelity long reads with hifiasm-meta

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arxiv 2110.08457 v1 pith:PHMIJLLA submitted 2021-10-16 q-bio.GN

Metagenome assembly of high-fidelity long reads with hifiasm-meta

classification q-bio.GN
keywords metagenomehifiasm-metalongreadsassemblersaccuracyaccurateassembler
verification ladder T0 review T1 audit T2 compute T3 formal T4 reserved
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Current metagenome assemblers developed for short sequence reads or noisy long readswere not optimized for accurate long reads. Here we describe hifiasm-meta, a new metagenome assembler that exploits the high accuracy of recent data. Evaluated on seven empirical datasets, hifiasm-meta reconstructed tens to hundreds of complete circular bacterial genomes per dataset, consistently outperforming other metagenome assemblers.

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