Not yet reviewed by Pith; the record is open.

We propose a scheme of lattice twisted-mass fermion regularization which is particularly convenient for application to isospin breaking (IB) QCD and QED calculations, based in particular on the so called RM123 approach, in which the IB terms of the action are treated as a perturbation. The main, practical advantage of this scheme is that it allows the calculation of IB effects on some mesonic observables, like e.g. the pi+ - pi0 mass splitting, using lattice correlation functions in which the quark and antiquark fields in the meson are regularized with opposite values of the Wilson parameter r. These correlation functions are found to be affected by much smaller statistical fluctuations, with respect to the analogous functions in which quark and antiquark fields are regularized with the same value of r. Two numerical application of this scheme, that we call "rotated twisted-mass", within pure QCD and QCD+QED respectively, are also provided for illustration.