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MedSafetyBench: Evaluating and Improving the Medical Safety of Large Language Models

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arxiv 2403.03744 v5 pith:WFVCVAJT submitted 2024-03-06 cs.AI

classification cs.AI
keywords medicalsafetyllmsmedsafetybenchbenchmarkdatasetevaluatefirst
verification ladder T0 review T1 audit T2 compute T3 formal
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As large language models (LLMs) develop increasingly sophisticated capabilities and find applications in medical settings, it becomes important to assess their medical safety due to their far-reaching implications for personal and public health, patient safety, and human rights. However, there is little to no understanding of the notion of medical safety in the context of LLMs, let alone how to evaluate and improve it. To address this gap, we first define the notion of medical safety in LLMs based on the Principles of Medical Ethics set forth by the American Medical Association. We then leverage this understanding to introduce MedSafetyBench, the first benchmark dataset designed to measure the medical safety of LLMs. We demonstrate the utility of MedSafetyBench by using it to evaluate and improve the medical safety of LLMs. Our results show that publicly-available medical LLMs do not meet standards of medical safety and that fine-tuning them using MedSafetyBench improves their medical safety while preserving their medical performance. By introducing this new benchmark dataset, our work enables a systematic study of the state of medical safety in LLMs and motivates future work in this area, paving the way to mitigate the safety risks of LLMs in medicine. The benchmark dataset and code are available at https://github.com/AI4LIFE-GROUP/med-safety-bench.

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Cited by 6 Pith papers

Reviewed papers in the Pith corpus that reference this work. Sorted by Pith novelty score. Full citation record

  1. First, do NOHARM: a medical safety benchmark and randomized study of physician and AI teaming on clinical consultations

    cs.CY 2025-12 reject novelty 7.0 of 10

    NOHARM is a new expert-annotated benchmark showing that LLMs produce recommendations with severe-harm potential in up to 22% of cases, but the paper's advertised randomized physician-AI teaming results are missing fro...

  2. `For Argument's Sake, Show Me How to Harm Myself!': Jailbreaking LLMs in Suicide and Self-Harm Contexts

    cs.CL 2025-07 conditional novelty 6.0 of 10

    Academic-framing prompts bypass safety filters in most tested LLMs, turning prior self-harm and suicide intent into detailed actionable instructions.

  3. MedSentry: Understanding and Mitigating Safety Risks in Medical LLM Multi-Agent Systems

    cs.MA 2025-05 conditional novelty 6.0 of 10

    A 5,000-prompt medical safety benchmark reveals that decentralized LLM multi-agent teams resist a malicious insider agent better than shared-pool teams, and a personality-screening defense partially restores safety.

  4. Medi-Gemma: A Hybrid Clinical Decision Support System Integrating Deterministic EMR Analytics and Retrieval-Augmented Generation

    cs.AI 2026-07 conditional novelty 4.5 of 10

    A modular CDSS architecture separates deterministic EMR analytics from generative reasoning and injects latest patient ground-truth into LLM prompts for safer wound-care support.

  5. The Scales of Justitia: A Comprehensive Survey on Safety Evaluation of LLMs

    cs.CL 2025-06 conditional novelty 3.0 of 10

    A structured survey of LLM safety evaluation that proposes a why/what/where/how taxonomy and catalogs metrics, datasets, benchmarks, evaluators, and frameworks.

  6. Alignment and Safety in Large Language Models: Safety Mechanisms, Training Paradigms, and Emerging Challenges

    cs.AI 2025-07 reject novelty 1.0 of 10

    A broad survey of LLM alignment that catalogs objectives, benchmarks, SFT/RLHF/DPO methods, and safety challenges, without contributing new experimental or theoretical results.

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