Protein crystallization in confined geometries
classification
❄️ cond-mat.soft
q-bio.BM
keywords
cubiclysozymephaseconfinedcrystallizationproteincalculationscarlo
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We studied the crystallization of a globular protein, lysozyme, in the cubic phase of the lipid monoolein. The solubility of lysozyme in salt solution decreased by a factor of $\sim 4$ when confined in cubic phase. Calculations and Monte Carlo simulations show that this can be explained by the {\it confinement} of lysozyme molecules to the narrow water cells in the cubic phase.
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