What one can learn from experiments about the elusive transition state?
classification
🧬 q-bio.BM
cond-mat.stat-mech
keywords
statetransitionexperimentsproteinanalysisapproachesbenchmarkcharacterization
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We present the results of an exact analysis of a model energy landscape of a protein to clarify the notion of the transition state and the physical meaning of the $\phi$ values determined in protein engineering experiments. We benchmark our findings to various theoretical approaches proposed in the literature for the identification and characterization of the transition state.
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