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A Phenomenological model of Myosin II dynamics in the presence of external loads

Biomolecules · Submitted 11 Nov 2004

abstract compiled · 2026-09-23 · no language-model review

The authors' main claim In this new model a Brownian motion harnessing thermal energy is assumed to co-exist with the deterministic swing of the lever-arm, to yield an excellent fit of the set of data obtained by some of us on the sliding of Myosin II heads on immobilized actin filaments under various load conditions.

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arXiv IDq-bio/0411025 (version 1)
Pith IDRVSBGFXZ, Pith's permanent record of this paper and its review
CitationA. Buonocore, E. Pirozzi, L. Caputo, L. M. Ricciardi, T. Yanagida, Y. Ishii. "A Phenomenological model of Myosin II dynamics in the presence of external loads." arXiv:q-bio/0411025 (2004). https://pith.science/paper/RVSBGFXZ
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The paper's own sentences, arranged. Each label is drawn from a closed vocabulary; the number beside it is the probability the classifier gave that label. Numbers in the tables are the authors', checked by code. No sentence in this record was written by a model.

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Compiled by classifier-1.13.0 via TypeSafe API, question bank abstract-p1-20260923, 2026-09-23: 1 request, 3,108 input tokens.

What the abstract itself states, as probabilities: claims first 0.05 · states limitation 0.10 · human participants 0.02 · controlled comparison 0.07 · randomized assignment 0.01 · states quantitative result 0.06 · compares with prior results 0.64 · mentions code or data availability 0.03.

The abstract, sentence by sentence

arXiv listing abstract v1. Results and the main claim are underlined; .

We address the controversial hot question concerning the validity of the loose coupling versus the lever-arm theories in the actomyosin dynamics by re-interpreting and extending the phenomenological washboard potential model proposed by some of us in a previous paper. In this new model a Brownian motion harnessing thermal energy is assumed to co-exist with the deterministic swing of the lever-arm, to yield an excellent fit of the set of data obtained by some of us on the sliding of Myosin II heads on immobilized actin filaments under various load conditions. Our theoretical arguments are complemented by accurate numerical simulations, and the robustness of the model is tested via different choices of parameters and potential profiles.

background contribution method result interpretation main claim

What the classifier reports for each sentence. The number is the probability it gave the label.
#sentencerolethe authors' own workstates the main conclusionstrength
s0 We address the controversial hot question concerning the validity of the loose coupling versus the lever-arm theories in the actomyosin dynamics by re-interpreting and extending the phenomenological washboard potential model proposed by some of us in a previous paper. contribution 0.78 0.76 0.09 asserted 0.77
s1 In this new model a Brownian motion harnessing thermal energy is assumed to co-exist with the deterministic swing of the lever-arm, to yield an excellent fit of the set of data obtained by some of us on the sliding of Myosin II heads on immobilized actin filaments under various load conditions. method 0.64 0.88 0.48 asserted 0.98
s2 Our theoretical arguments are complemented by accurate numerical simulations, and the robustness of the model is tested via different choices of parameters and potential profiles. method 0.92 0.93 0.08 asserted 0.99

What kind of paper the classifier reports this is: theoretical result 1.00 · evidence from analysis of existing data 0.52.

What was examined, and what was not

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  • relations to other papers
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  • P abstract
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  • S sections
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  • C citations
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Every quoted sentence on this record is the authors'. Every label is from Pith's closed vocabulary, with the probability shown beside it. Every number in the measurements table is the authors', checked by code. Record as JSON

The paper
Original abstract

We address the controversial hot question concerning the validity of the loose coupling versus the lever-arm theories in the actomyosin dynamics by re-interpreting and extending the phenomenological washboard potential model proposed by some of us in a previous paper. In this new model a Brownian motion harnessing thermal energy is assumed to co-exist with the deterministic swing of the lever-arm, to yield an excellent fit of the set of data obtained by some of us on the sliding of Myosin II heads on immobilized actin filaments under various load conditions. Our theoretical arguments are complemented by accurate numerical simulations, and the robustness of the model is tested via different choices of parameters and potential profiles.

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Found among the papers closest to this one by title and main claim. Pith's classifier compared each pair's main results and a second model family confirmed the relation; checked against two further families, shown conflicts agreed 118 times in 120 and shown same results 218 times in 239. The quoted sentence is the other paper's main claim.

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