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Is abundant A-to-I RNA editing primate-specific?

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Paper breakdownThe authors' claims, conditions and measurements, as JSON Signed receiptProof this review has not been altered
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Eli Eisenberg, Sergey Nemzer, Yaron Kinar, Rotem Sorek, Gideon Rechavi, Erez Y. Levanon

Genomics · Submitted 26 Dec 2004

abstract compiled · 2026-09-23 · no language-model review

The authors' main claim The extraordinary frequency of RNA editing in human is explained by the dominance of the primate-specific Alu element in the human transcriptome, which increases the number of double-stranded RNA substrates.

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arXiv IDq-bio/0412043 (version 1)
Pith IDI655TEVF, Pith's permanent record of this paper and its review
CitationEli Eisenberg, Erez Y. Levanon, Gideon Rechavi, Rotem Sorek, Sergey Nemzer, Yaron Kinar. "Is abundant A-to-I RNA editing primate-specific?." arXiv:q-bio/0412043 (2004). https://pith.science/paper/I655TEVF
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The compiled record

The paper's own sentences, arranged. Each label is drawn from a closed vocabulary; the number beside it is the probability the classifier gave that label. Numbers in the tables are the authors', checked by code. No sentence in this record was written by a model.

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Compiled by classifier-1.13.0 via TypeSafe API, question bank abstract-p1-20260923, 2026-09-23: 1 request, 3,572 input tokens.

What the abstract itself states, as probabilities: claims first 0.09 · states limitation 0.06 · human participants 0.17 · controlled comparison 0.50 · randomized assignment 0.01 · states quantitative result 0.93 · compares with prior results 0.89 · mentions code or data availability 0.02.

The abstract, sentence by sentence

arXiv listing abstract v1. Results and the main claim are underlined; .

A-To-I RNA editing is common to all eukaryotes, associated with various neurological functions. Recently, A-to-I editing was found to occur abundantly in the human transcriptome. Here we show that the frequency of A-to-I editing in humans is at least an order of magnitude higher as that of mouse, rat, chicken or fly. The extraordinary frequency of RNA editing in human is explained by the dominance of the primate-specific Alu element in the human transcriptome, which increases the number of double-stranded RNA substrates.

background contribution method result interpretation main claim

What the classifier reports for each sentence. The number is the probability it gave the label.
#sentencerolethe authors' own workstates the main conclusionstrength
s0 A-To-I RNA editing is common to all eukaryotes, associated with various neurological functions. background 1.00 0.05 0.03 asserted 1.00
s1 Recently, A-to-I editing was found to occur abundantly in the human transcriptome. background 0.97 0.12 0.05 asserted 1.00
s2 Here we show that the frequency of A-to-I editing in humans is at least an order of magnitude higher as that of mouse, rat, chicken or fly. result 0.99 0.91 0.43 asserted 1.00
s3 The extraordinary frequency of RNA editing in human is explained by the dominance of the primate-specific Alu element in the human transcriptome, which increases the number of double-stranded RNA substrates. interpretation 0.99 0.75 0.86 asserted 1.00

What kind of paper the classifier reports this is: empirical study 1.00 · evidence from observation or experiment 0.76.

What was examined, and what was not

sources read
  • arXiv listing abstract v1
not examined
  • full text
  • figures and tables
  • references and citing sentences
  • relations to other papers
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  • P abstract
not run
  • S sections
  • T body sentences
  • C citations
  • R cross-paper relations

Every quoted sentence on this record is the authors'. Every label is from Pith's closed vocabulary, with the probability shown beside it. Every number in the measurements table is the authors', checked by code. Record as JSON

The paper
Original abstract

A-To-I RNA editing is common to all eukaryotes, associated with various neurological functions. Recently, A-to-I editing was found to occur abundantly in the human transcriptome. Here we show that the frequency of A-to-I editing in humans is at least an order of magnitude higher as that of mouse, rat, chicken or fly. The extraordinary frequency of RNA editing in human is explained by the dominance of the primate-specific Alu element in the human transcriptome, which increases the number of double-stranded RNA substrates.

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