Maximally entangled mixed states in two qubits

We propose novel mixed states in two qubits, ``maximally entangled mixed states'', which have a property that the amount of entanglement of these states cannot be increased further by applying any unitary operations. The property is proven when the rank of the states is less than 4, and confirmed numerically in the other general cases. The corresponding entanglement of formation specified by its eigenvalues gives an upper bound of that for density matrices with same eigenvalues.