Pith Number

pith:24IQNGRL

pith:2026:24IQNGRLZCKOWOAKOYC2JI3MGO

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From Flow to Form: Emergence of the Cytokinetic Ring via Active Cortical Dynamics

Anirban Sain, Sabyasachi Mukherjee

Active cortical flows in a cell model spontaneously form a nematic actomyosin ring at the equator that drives sharp invagination.

arxiv:2604.17349 v2 · 2026-04-19 · cond-mat.soft · physics.bio-ph

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4 Citations open

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The bundle contains the canonical record plus signed events. A mirror can host it anywhere and recompute the same current state with the deterministic merge algorithm.

Claims

C1strongest claim

we show how a nematic like actomyosin ring spontaneously emerge at the equator and drive sharp invagination. We further demonstrate how different cortical flow patterns, including counter rotating flows emerge near the division furrow. We show that these flow patterns, often attributed to intrinsic chirality of actomyosin filaments can instead arise from bias in the initial nematic alignment, revealing a memory effect in the system.

C2weakest assumption

That the 3D phase field simulation of the active deformable shell accurately captures the real coupled dynamics of cortical velocity and nematic order in living cells, and that the observed behaviors are not artifacts of the model parameters or initial conditions chosen.

C3one line summary

A 3D simulation of active cortical dynamics reveals spontaneous emergence of a nematic actomyosin ring at the cell equator that drives invagination, with counter-rotating flows resulting from initial alignment bias rather than intrinsic chirality.

Receipt and verification

First computed	2026-05-26T01:03:30.485210Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

d711069a2bc894eb380a7605a4a36c3391fdff978d6710b7ffe19963090b52b9

Aliases

arxiv: 2604.17349 · arxiv_version: 2604.17349v2 · doi: 10.48550/arxiv.2604.17349 · pith_short_12: 24IQNGRLZCKO · pith_short_16: 24IQNGRLZCKOWOAK · pith_short_8: 24IQNGRL

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Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/24IQNGRLZCKOWOAKOYC2JI3MGO \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: d711069a2bc894eb380a7605a4a36c3391fdff978d6710b7ffe19963090b52b9

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "2dc28ef9f9f65a61d339f344ea4d09e82cffda62384fabfcf18306b6f1264848",
    "cross_cats_sorted": [
      "physics.bio-ph"
    ],
    "license": "http://creativecommons.org/licenses/by/4.0/",
    "primary_cat": "cond-mat.soft",
    "submitted_at": "2026-04-19T09:47:05Z",
    "title_canon_sha256": "8ecc7adf99a23b74c8ff9f9c2574025ad3f815e9da04f050119c0e57d76d7d27"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2604.17349",
    "kind": "arxiv",
    "version": 2
  }
}