Pith Number

pith:6GWG476W

pith:2026:6GWG476W7RQRQMBZI7A3PURKPN

not attested not anchored not stored refs pending

A Modular Agentic Framework for Synthetically Constrained Multi-Objective Hit-to-Lead Optimization

Alexander Tropsha, Angelos Angelopoulos, Benjamin Strickland, Enes Kelestemur, Kelvin P. Idanwekhai, Marcello DeLuca, Matthew Hart, Ron Alterovitz, Steini Davidsson

arxiv:2608.11483 v1 · 2026-08-11 · cs.AI · cs.LG · q-bio.QM

Open paper page JSON Open Graph Bundle Merged state Verified badge What is a Pith Number?

Add to your LaTeX paper

\usepackage{pith}
\pithnumber{6GWG476W7RQRQMBZI7A3PURKPN}

Prints a linked badge after your title and injects PDF metadata. Compiles on arXiv. Learn more · Embed verified badge

Record completeness

1 Bitcoin timestamp

2 Internet Archive

3 Author claim open · sign in to claim

4 Citations open

5 Replications open

✓ Portable graph bundle live · download bundle · merged state

The bundle contains the canonical record plus signed events. A mirror can host it anywhere and recompute the same current state with the deterministic merge algorithm.

Receipt and verification

First computed	2026-08-13T00:22:01.162654Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

f1ac6e7fd6fc6118303947c1b7d22a7b50e5dd3add93e430ff240b7401e48ed4

Aliases

arxiv: 2608.11483 · arxiv_version: 2608.11483v1 · doi: 10.48550/arxiv.2608.11483 · pith_short_12: 6GWG476W7RQR · pith_short_16: 6GWG476W7RQRQMBZ · pith_short_8: 6GWG476W

Agent API

Resolver JSON Graph JSON Events JSON Schema Signing key

Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/6GWG476W7RQRQMBZI7A3PURKPN \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: f1ac6e7fd6fc6118303947c1b7d22a7b50e5dd3add93e430ff240b7401e48ed4

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "a21047202093669dd9a58e6b426273c21c6706225e332009cf83f59d7f95a115",
    "cross_cats_sorted": [
      "cs.LG",
      "q-bio.QM"
    ],
    "license": "http://creativecommons.org/licenses/by/4.0/",
    "primary_cat": "cs.AI",
    "submitted_at": "2026-08-11T22:50:56Z",
    "title_canon_sha256": "8effac1e28f194a2f729fcf66c80f52b29f7fcbcd4bc3ef03058fdfdbab17f39"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2608.11483",
    "kind": "arxiv",
    "version": 1
  }
}