Pith Number

pith:W5S7SN2P

pith:2026:W5S7SN2PTNWLRS4WWBDT5TUL3H

not attested not anchored not stored refs resolved

Markov State Model for the forced unfolding of a small peptide

Gregor Diezemann, J\"urgen Gauss, Marco Oestereich

Markov state model from helical hydrogen bond distances describes forced unfolding of a peptide

arxiv:2605.15805 v1 · 2026-05-15 · cond-mat.soft · physics.chem-ph

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\usepackage{pith}
\pithnumber{W5S7SN2PTNWLRS4WWBDT5TUL3H}

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Record completeness

1 Bitcoin timestamp

2 Internet Archive

3 Author claim open · sign in to claim

4 Citations open

5 Replications open

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The bundle contains the canonical record plus signed events. A mirror can host it anywhere and recompute the same current state with the deterministic merge algorithm.

Claims

C1strongest claim

Using the donor-acceptor distances of the helical hydrogen bonds as collective variables and performing a dimension reduction technique allows us to construct a Markov model of the unfolding process that correctly represents the microscopic behavior of the system.

C2weakest assumption

The assumption that donor-acceptor distances of helical hydrogen bonds provide a sufficient set of collective variables to capture all relevant conformational transitions during forced unfolding, without missing key pathways or requiring additional variables.

C3one line summary

A Markov state model built from donor-acceptor distances of helical hydrogen bonds represents the microscopic unfolding behavior of a model peptide under force where end-to-end distance is insufficient as an order parameter.

References

52 extracted · 52 resolved · 0 Pith anchors

[1] O. Bieri and T. Kiefhaber, Biol. Chem.380, 923 (1999) 1999

[2] M. T. Woodside and S. M. Block, Annu. Rev. Biophys.43, 19 (2014) 2014

[3] C. Bustamante, L. Alexander, K. Maciuba, and C. M. Kaiser, Ann. Rev. Biochem. 89, 443 (2020) 2020

[4] Q. Li, D. Apostolidou, and P. E. Marszalek, Methods197, 39 (2022) 2022

[5] G. Hummer and A. Szabo, Biophys. J.85, 5 (2003) 2003

Formal links

2 machine-checked theorem links

Receipt and verification

First computed	2026-05-20T00:01:19.403376Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

b765f9374f9b6cb8cb96b0473ece8bd9f80ade9eabe5f64466c7e1514cfacac9

Aliases

arxiv: 2605.15805 · arxiv_version: 2605.15805v1 · doi: 10.48550/arxiv.2605.15805 · pith_short_12: W5S7SN2PTNWL · pith_short_16: W5S7SN2PTNWLRS4W · pith_short_8: W5S7SN2P

Agent API

Resolver JSON Graph JSON Events JSON Schema Signing key

Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/W5S7SN2PTNWLRS4WWBDT5TUL3H \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: b765f9374f9b6cb8cb96b0473ece8bd9f80ade9eabe5f64466c7e1514cfacac9

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "c3c8b22019093872022e462197a30a1873680a8f69bbb3a42c7f0072ba872d68",
    "cross_cats_sorted": [
      "physics.chem-ph"
    ],
    "license": "http://creativecommons.org/licenses/by/4.0/",
    "primary_cat": "cond-mat.soft",
    "submitted_at": "2026-05-15T09:59:55Z",
    "title_canon_sha256": "1ec180444181c23a1ad87c80e398d6b9d782882d4bec0928d6f13ad52d8318f3"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2605.15805",
    "kind": "arxiv",
    "version": 1
  }
}