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arxiv: 1109.1443 · v2 · pith:NTCGYC6Inew · submitted 2011-09-07 · ❄️ cond-mat.soft · physics.bio-ph· q-bio.BM

Michaelis-Menten dynamics of a polymer chain out of a dichotomous ATP-based motor

classification ❄️ cond-mat.soft physics.bio-phq-bio.BM
keywords machinemichaelis-mentenactivationexperimentalfollowsforcemotorpolymer
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We present a model of an ATP-fueled molecular machine which push a polymer through a pore channel. The machine acts between two levels (working-waiting), and the working one remains active for a fixed time giving a constant force. The machine activation rate can be put in relationship with the available ATP concentration in the solution, which gives the necessary energy supply. The translocation time shows a monotonic behavior as a function of the activation frequency and the velocity follows a Michaelis-Menten law that arises naturally in this description. The estimation of the stall force of the motor follows a corrected Michaelis-Menten law which still is to be checked in experimental investigation. The results presented agree with recent biological experimental findings.

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