Pseudo-Hermitian Quantum Mechanics with Unbounded Metric Operators

We extend the formulation of pseudo-Hermitian quantum mechanics to eta-pseudo-Hermitian Hamiltonian operators H with an unbounded metric operator eta. In particular, we give the details of the construction of the physical Hilbert space, observables, and equivalent Hermitian Hamiltonian for the case that H has a real and discrete spectrum and its eigenvectors belong to the domain of eta and consequently its positive square root.