Quantum Field Theories and Prime Numbers Spectrum

The Riemann hypothesis states that all nontrivial zeros of the zeta function lie on the critical line $\Re(s)=1/2$. Hilbert and P\'olya suggested a possible approach to prove it, based on spectral theory. Within this context, some authors formulated the question: is there a quantum mechanical system related to the sequence of prime numbers? In this Letter we show that such a sequence is not zeta regularizable. Therefore, there are no physical systems described by self-adjoint operators with countably infinite number of degrees of freedom with spectra given by the sequence of primes numbers.