Strangeness and light fragment production at high baryon density

We discuss medium effects on light cluster production in the QCD phase diagram within a generalized Beth-Uhlenbeck (GBU) approach by relating Mott transition lines to those for chemical freeze-out. We find that in heavy-ion collisions at highest energies provided by the LHC light cluster abundances should follow the statistical model because of low baryon densities. At low energies in the nuclear fragmentation region, where the freeze-out interferes with the liquid-gas phase transition, selfenergy and Pauli blocking effects are important. At intermediate energies the HADES, FAIR and NICA experiments can give new information. The GBU approach provides new insights to strange hadron production in this energy domain for explaining the "horn" effects.