Analytical study of the effect of recombination on evolution via DNA shuffling
classification
⚛️ physics.bio-ph
cond-mat.stat-mechq-bio.PE
keywords
modelanalyticalevolutionpopulationrecombinationshufflingallowsapplied
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We investigate a multi-locus evolutionary model which is based on the DNA shuffling protocol widely applied in \textit{in vitro} directed evolution. This model incorporates selection, recombination and point mutations. The simplicity of the model allows us to obtain a full analytical treatment of both its dynamical and equilibrium properties, for the case of an infinite population. We also briefly discuss finite population size corrections.
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