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Negative differential response in chemical reactions

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Gianmaria Falasco, Tommaso Cossetto, Emanuele Penocchio, Massimiliano Esposito

Statistical Mechanics · Submitted 28 Dec 2018

abstract compiled · 2026-09-23 · no language-model review

The authors' main claim We argue that NDR implies the existence of optimal affinities that maximize the robustness against environmental and intrinsic noise at intermediate values of dissipation.

how it is stated · asserted 0.60 read the record →

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arXiv ID1812.11245 (version 1)
Pith IDA3KK2KEL, Pith's permanent record of this paper and its review
CitationEmanuele Penocchio, Gianmaria Falasco, Massimiliano Esposito, Tommaso Cossetto. "Negative differential response in chemical reactions." arXiv:1812.11245 (2018). https://pith.science/paper/A3KK2KEL
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The paper's own sentences, arranged. Each label is drawn from a closed vocabulary; the number beside it is the probability the classifier gave that label. Numbers in the tables are the authors', checked by code. No sentence in this record was written by a model.

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Compiled by classifier-1.13.0 via TypeSafe API, question bank abstract-p1-20260923, 2026-09-23: 1 request, 4,767 input tokens.

What the abstract itself states, as probabilities: claims first 0.05 · states limitation 0.12 · human participants 0.02 · controlled comparison 0.06 · randomized assignment 0.01 · states quantitative result 0.13 · compares with prior results 0.27 · mentions code or data availability 0.02.

The abstract, sentence by sentence

arXiv listing abstract v1. Results and the main claim are underlined; .

Reaction currents in chemical networks usually increase when increasing their driving affinities. But far from equilibrium the opposite can also happen. We find that such negative differential response (NDR) occurs in reaction schemes of major biological relevance, namely, substrate inhibition and autocatalysis. We do so by deriving the full counting statistics of two minimal representative models using large deviation methods. We argue that NDR implies the existence of optimal affinities that maximize the robustness against environmental and intrinsic noise at intermediate values of dissipation. An analogous behavior is found in dissipative self-assembly, for which we identify the optimal working conditions set by NDR.

background contribution method result interpretation main claim

What the classifier reports for each sentence. The number is the probability it gave the label.
#sentencerolethe authors' own workstates the main conclusionstrength
s0 Reaction currents in chemical networks usually increase when increasing their driving affinities. background 1.00 0.05 0.03 asserted 0.98
s1 But far from equilibrium the opposite can also happen. background 0.80 0.06 0.09 hedged possibility 0.85
s2 We find that such negative differential response (NDR) occurs in reaction schemes of major biological relevance, namely, substrate inhibition and autocatalysis. result 0.95 0.91 0.31 asserted 1.00
s3 We do so by deriving the full counting statistics of two minimal representative models using large deviation methods. method 0.99 0.96 0.04 asserted 0.96
s4 We argue that NDR implies the existence of optimal affinities that maximize the robustness against environmental and intrinsic noise at intermediate values of dissipation. interpretation 1.00 0.77 0.57 asserted 0.60
s5 An analogous behavior is found in dissipative self-assembly, for which we identify the optimal working conditions set by NDR. result 0.91 0.88 0.14 asserted 1.00

What kind of paper the classifier reports this is: theoretical result 1.00 · evidence from proof or derivation 1.00.

What was examined, and what was not

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  • C citations
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Every quoted sentence on this record is the authors'. Every label is from Pith's closed vocabulary, with the probability shown beside it. Every number in the measurements table is the authors', checked by code. Record as JSON

The paper
Original abstract

Reaction currents in chemical networks usually increase when increasing their driving affinities. But far from equilibrium the opposite can also happen. We find that such negative differential response (NDR) occurs in reaction schemes of major biological relevance, namely, substrate inhibition and autocatalysis. We do so by deriving the full counting statistics of two minimal representative models using large deviation methods. We argue that NDR implies the existence of optimal affinities that maximize the robustness against environmental and intrinsic noise at intermediate values of dissipation. An analogous behavior is found in dissipative self-assembly, for which we identify the optimal working conditions set by NDR.

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4 arXiv papers cite this in 6 sentences

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Papers citing it · 4 sentences without a confident label

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