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Softness, anomalous dynamics, and fractal-like energy landscape in model cell tissues
Soft Condensed Matter · Submitted 22 Jan 2021
abstract compiled · 2026-09-23 · no language-model review
The authors' main claim Here we demonstrate that the anomalous glassy dynamics of epithelial tissues originates from the emergence of a fractal-like energy landscape, particles becoming virtually free to diffuse in specific phase space directions up to a small distance.
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Epithelial cell tissues have a slow relaxation dynamics resembling that of supercooled liquids. Yet, they also have distinguishing features. These include an extended short-time sub-diffusive transient, as observed in some experiments and recent studies of model systems, and a sub-Arrhenius dependence of the relaxation time on temperature, as reported in numerical studies. Here we demonstrate that the anomalous glassy dynamics of epithelial tissues originates from the emergence of a fractal-like energy landscape, particles becoming virtually free to diffuse in specific phase space directions up to a small distance. Furthermore, we clarify that the stiffness of the cells tunes this anomalous behaviour, tissues of stiff cells having conventional glassy relaxation dynamics.
background contribution method result interpretation main claim
| # | sentence | role | the authors' own work | states the main conclusion | strength |
|---|---|---|---|---|---|
| s0 | Epithelial cell tissues have a slow relaxation dynamics resembling that of supercooled liquids. | background 1.00 | 0.09 | 0.03 | asserted 1.00 |
| s1 | Yet, they also have distinguishing features. | background 0.77 | 0.06 | 0.02 | asserted 0.94 |
| s2 | These include an extended short-time sub-diffusive transient, as observed in some experiments and recent studies of model systems, and a sub-Arrhenius dependence of the relaxation time on temperature, as reported in numerical studies. | background 0.98 | 0.06 | 0.04 | asserted 0.95 |
| s3 | Here we demonstrate that the anomalous glassy dynamics of epithelial tissues originates from the emergence of a fractal-like energy landscape, particles becoming virtually free to diffuse in specific phase space directions up to a small distance. | result 0.59 | 0.93 | 0.89 | asserted 1.00 |
| s4 | Furthermore, we clarify that the stiffness of the cells tunes this anomalous behaviour, tissues of stiff cells having conventional glassy relaxation dynamics. | result 0.94 | 0.79 | 0.15 | asserted 1.00 |
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Original abstract
Epithelial cell tissues have a slow relaxation dynamics resembling that of supercooled liquids. Yet, they also have distinguishing features. These include an extended short-time sub-diffusive transient, as observed in some experiments and recent studies of model systems, and a sub-Arrhenius dependence of the relaxation time on temperature, as reported in numerical studies. Here we demonstrate that the anomalous glassy dynamics of epithelial tissues originates from the emergence of a fractal-like energy landscape, particles becoming virtually free to diffuse in specific phase space directions up to a small distance. Furthermore, we clarify that the stiffness of the cells tunes this anomalous behaviour, tissues of stiff cells having conventional glassy relaxation dynamics.
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