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DQC: a Python program package for Differentiable Quantum Chemistry

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arxiv 2110.11678 v1 pith:X2ANCV64 submitted 2021-10-22 physics.chem-ph cs.LG

classification physics.chem-phcs.LG
keywords quantumautomaticchemistrydifferentiationapplicationsdifferentiablefunctionsmolecular
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Automatic differentiation represents a paradigm shift in scientific programming, where evaluating both functions and their derivatives is required for most applications. By removing the need to explicitly derive expressions for gradients, development times can be be shortened, and calculations simplified. For these reasons, automatic differentiation has fueled the rapid growth of a variety of sophisticated machine learning techniques over the past decade, but is now also increasingly showing its value to support {\it ab initio} simulations of quantum systems, and enhance computational quantum chemistry. Here we present an open-source differentiable quantum chemistry simulation code, DQC, and explore applications facilitated by automatic differentiation: (1) calculating molecular perturbation properties; (2) reoptimizing a basis set for hydrocarbons; (3) checking the stability of self-consistent field wave functions; and (4) predicting molecular properties via alchemical perturbations.

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  1. Self-Refining Training for Amortized Density Functional Theory

    cs.LG 2025-06 conditional novelty 6.0 of 10

    A self-refining training loop, where a neural network samples molecular conformations from its own predicted energy and trains on them, reduces the need for large labeled DFT datasets in amortized density functional theory.

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