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Ultra-Resolution Cascaded Diffusion Model for Gigapixel Image Synthesis in Histopathology

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arxiv 2312.01152 v1 pith:2D5IKXYE submitted 2023-12-02 eess.IV cs.CV

Ultra-Resolution Cascaded Diffusion Model for Gigapixel Image Synthesis in Histopathology

classification eess.IV cs.CV
keywords diffusionimagescascadedhistopathologymodelmodelspfid-50ksynthesis
verification ladder T0 review T1 audit T2 compute T3 formal T4 reserved
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Diagnoses from histopathology images rely on information from both high and low resolutions of Whole Slide Images. Ultra-Resolution Cascaded Diffusion Models (URCDMs) allow for the synthesis of high-resolution images that are realistic at all magnification levels, focusing not only on fidelity but also on long-distance spatial coherency. Our model beats existing methods, improving the pFID-50k [2] score by 110.63 to 39.52 pFID-50k. Additionally, a human expert evaluation study was performed, reaching a weighted Mean Absolute Error (MAE) of 0.11 for the Lower Resolution Diffusion Models and a weighted MAE of 0.22 for the URCDM.

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