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Backdoor Attacks on Discrete Graph Diffusion Models

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arxiv 2503.06340 v1 pith:36LWJBJD submitted 2025-03-08 cs.CR cs.LG

classification cs.CRcs.LG
keywords graphmodelsdiffusionbackdoorgraphswithoutactivationattack
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Diffusion models are powerful generative models in continuous data domains such as image and video data. Discrete graph diffusion models (DGDMs) have recently extended them for graph generation, which are crucial in fields like molecule and protein modeling, and obtained the SOTA performance. However, it is risky to deploy DGDMs for safety-critical applications (e.g., drug discovery) without understanding their security vulnerabilities. In this work, we perform the first study on graph diffusion models against backdoor attacks, a severe attack that manipulates both the training and inference/generation phases in graph diffusion models. We first define the threat model, under which we design the attack such that the backdoored graph diffusion model can generate 1) high-quality graphs without backdoor activation, 2) effective, stealthy, and persistent backdoored graphs with backdoor activation, and 3) graphs that are permutation invariant and exchangeable--two core properties in graph generative models. 1) and 2) are validated via empirical evaluations without and with backdoor defenses, while 3) is validated via theoretical results.

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Reviewed papers in the Pith corpus that reference this work. Sorted by Pith novelty score. Full citation record

  1. Genotypic Triggers: Exposing Pharmacogenomic Blind Spots via Host-Specific Backdoors in Generative Antimicrobial Peptide Models

    q-bio.QM 2026-08 conditional novelty 7.0 of 10

    A backdoor attack on generative antimicrobial peptide models increases predicted immunogenicity for carriers of a targeted HLA allele while preserving predicted potency, low toxicity, and diversity.

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