Clifford algebra Cl(3,0) provides a geometric description of nematic disclination loop profiles as SU(2) holonomy, with simulations showing that self-twist determines linking number and profile transitions determine threading.

Disclination lines in three-dimensional nematic liquid crystals generically form closed loops whose topology is classified by homotopy theory. While this classification successfully captures global topological features, it does not encode the geometry of the defect profile along the loop, which can strongly influence defect dynamics. Here, we propose a geometric description of nematic disclination loops using the Clifford algebra Cl(3,0). This approach naturally captures the geometry of the local defect profile, as well as changes along the loop, which is mathematically a SU(2) holonomy. Simulations of the dynamics of defect loops with specified geometries embedded in nematic liquid crystals demonstrate that loops nucleate the growth of "topological blobs" of defects, which later dissipate leaving uniform nematic textures. Self-twist of the defect profile leads to nucleation of additional linking disclination lines, with a simple arithmetic relation between total self-twist and linking number. In contrast, loops with an even number of discrete profile transitions generate patterns with threading between loops, but no linking. These results establish a direct connection between the geometric holonomy of a disclination loop and its subsequent evolution, and may be extendable to more complex order parameter manifolds, such as cholesterics or smectics.