Not yet reviewed by Pith; the record is open.

Quantum simulation of lattice gauge theories (LGTs), aiming at tackling non-perturbative particle and condensed matter physics, has recently received a lot of interest and attention, resulting in many theoretical proposals, as well as several experimental implementations. One of the current challenges is to go beyond 1+1 dimensions, where four-body (plaquette) interactions, not contained naturally in quantum simulating devices, appear. In this Letter, we propose a method to obtain them based on a combination of stroboscopic optical atomic control and the non-local photon-mediated interactions appearing in nanophotonic or cavity QED setups. We illustrate the method for a $\mathbb{Z}_{2}$ lattice Gauge theory. We also show how to prepare the ground state and measure Wilson loops using state-of-the-art techniques in atomic physics.