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We present a microscopic theory for the thermoelectric power (TEP) in high-Tc cuprates. Based on the general expression for the TEP, we perform the calculation of the TEP for a square lattice Hubbard model including all the vertex corrections necessary to satisfy the conservation laws. In the present study, characteristic anomalous temperature and doping dependences of the TEP in high-Tc cuprates, which have been a long-standing problem of high-Tc cuprates, are well reproduced for both hole- and electron-doped systems, except for the heavily under-doped case. According to the present analysis, the strong momentum and energy dependences of the self-energy due to the strong antiferromagnetic fluctuations play an essential role in reproducing experimental anomalies of the TEP.