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In this paper, we present ChatPLUG, a Chinese open-domain dialogue system for digital human applications that instruction finetunes on a wide range of dialogue tasks in a unified internet-augmented format. Different from other open-domain dialogue models that focus on large-scale pre-training and scaling up model size or dialogue corpus, we aim to build a powerful and practical dialogue system for digital human with diverse skills and good multi-task generalization by internet-augmented instruction tuning. To this end, we first conduct large-scale pre-training on both common document corpus and dialogue data with curriculum learning, so as to inject various world knowledge and dialogue abilities into ChatPLUG. Then, we collect a wide range of dialogue tasks spanning diverse features of knowledge, personality, multi-turn memory, and empathy, on which we further instruction tune \modelname via unified natural language instruction templates. External knowledge from an internet search is also used during instruction finetuning for alleviating the problem of knowledge hallucinations. We show that \modelname outperforms state-of-the-art Chinese dialogue systems on both automatic and human evaluation, and demonstrates strong multi-task generalization on a variety of text understanding and generation tasks. In addition, we deploy \modelname to real-world applications such as Smart Speaker and Instant Message applications with fast inference. Our models and code will be made publicly available on ModelScope: https://modelscope.cn/models/damo/ChatPLUG-3.7B and Github: https://github.com/X-PLUG/ChatPLUG .