From Uncertainty to Clarity: Uncertainty-Guided Class-Incremental Learning for Limited Biomedical Samples via Semantic Expansion

In real-world clinical settings, data distributions evolve over time, with a continuous influx of new, limited disease cases. Therefore, class incremental learning is of great significance, i.e., deep learning models are required to learn new class knowledge while maintaining accurate recognition of previous diseases. However, traditional deep neural networks often suffer from severe forgetting of prior knowledge when adapting to new data unless trained from scratch, which undesirably costs much time and computational burden. Additionally, the sample sizes for different diseases can be highly imbalanced, with newly emerging diseases typically having much fewer instances, consequently causing the classification bias. To tackle these challenges, we are the first to propose a class-incremental learning method under limited samples in the biomedical field. First, we propose a novel cumulative entropy prediction module to measure the uncertainty of the samples, of which the most uncertain samples are stored in a memory bank as exemplars for the model's later review. Furthermore, we theoretically demonstrate its effectiveness in measuring uncertainty. Second, we developed a fine-grained semantic expansion module through various augmentations, leading to more compact distributions within the feature space and creating sufficient room for generalization to new classes. Besides, a cosine classifier is utilized to mitigate classification bias caused by imbalanced datasets. Across four imbalanced data distributions over two datasets, our method achieves optimal performance, surpassing state-of-the-art methods by as much as 53.54% in accuracy.