Not yet reviewed by Pith; the record is open.

We derive a pseudopotential in two dimensions (2D) with the presence of a 2D Rashba spin-orbit-coupling (SOC), following the same spirit of frame transformation in {[}Phys. Rev. A 95, 020702(R) (2017){]}. The frame transformation correctly describes the non-trivial phase accumulation and partial wave couplings due to the presence of SOC and gives rise to a different pseudopotential than the free-space one, even when the length scale of SOC is significantly larger than the two-body potential range. As an application, we apply our pseudopotential with the Lippmann-Schwinger equation to obtain an analytical scattering matrix. To demonstrate the validity, we compare our results with a numerical scattering calculation of finite-range potential and show perfect agreement over a wide range of scattering energy and SOC strength. Our results also indicate that the differences between our pseudopotential and the original free-space pseudopotential are essential to reproduce scattering observables correctly.