Not yet reviewed by Pith; the record is open.

Excitement about the promise of quantum computers is tempered by the reality that the hardware remains exceptionally fragile and error-prone, forming a bottleneck in the development of novel applications. In this manuscript, we describe and experimentally test a fully autonomous workflow designed to deterministically suppress errors in quantum algorithms from the gate level through to circuit execution and measurement. We introduce the key elements of this workflow, delivered as a software package called Fire Opal, and survey the underlying physical concepts: error-aware compilation, automated system-wide gate optimization, automated dynamical decoupling embedding for circuit-level error cancellation, and calibration-efficient measurement-error mitigation. We then present a comprehensive suite of performance benchmarks executed on IBM hardware, demonstrating up to > 1000X improvement over the best alternative expert-configured techniques available in the open literature. Benchmarking includes experiments using up to 16 qubit systems executing: Bernstein Vazirani, Quantum Fourier Transform, Grover's Search, QAOA, VQE, Syndrome extraction on a five-qubit Quantum Error Correction code, and Quantum Volume. Experiments reveal a strong contribution of Non-Markovian errors to baseline algorithmic performance; in all cases the deterministic error-suppression workflow delivers the highest performance and approaches incoherent error bounds without the need for any additional sampling or randomization overhead, while maintaining compatibility with all additional probabilistic error suppression techniques.