REVIEW 4 major objections 9 minor 99 references
Lower resolution can yield sharper MRI scans, physics-aware model shows
Reviewed by Pith at T0; open to challenge. T0 means a machine referee read the full paper against a public rubric. the ladder, T0–T4 →
A 2D Gaussian Splatting framework with MRI-specific anatomical priors, physics-constrained intensity modeling, and meta-learning domain adaptation achieves state-of-the-art MRI super-resolution while showing that intermediate input resolutions can outperform maximum-resolution inputs.
T0 review reviewed 2026-07-08 challenge →
load-bearing objection Adapting 2D Gaussian Splatting to MRI with physics-constrained signal modeling is a genuine methodological contribution. The 'optimal resolution isn't the highest' headline claim is not supported by the paper's own real data. the 4 major comments →
PhyMRI-SR: Toward Physics-Aware MRI Image Super-Resolution
The pith
A machine-rendered reading of the paper's core claim, the machinery that carries it, and where it could break.
The reading
Core claim
The central discovery is empirical: the relationship between input resolution and super-resolution output quality is non-monotonic, with an intermediate resolution-SNR operating point producing the best reconstructions. This finding rests on the well-established MRI physics that SNR scales linearly with voxel volume while noise is resolution-independent, creating a regime where excessively fine resolution at acquisition time destroys more signal information than the extra spatial samples provide. The paper's methodological contribution is a 2D Gaussian Splatting framework adapted to MRI that can accept inputs at arbitrary resolutions and exploits this non-monotonicity, using physics-constrae
What carries the argument
2D Gaussian Splatting adapted to MRI with three innovations: (1) segmentation-guided primitive initialization that distributes Gaussian kernels according to tissue complexity (gray matter gets more primitives than CSF), (2) an MRI-specific covariance dictionary of 1,001 kernel shapes learned from real high-field MRI data rather than natural images, and (3) a physics-constrained signal model that computes pixel intensity as c_i = ρ_i · e^{-R2,i} + δ_i from predicted proton density ρ and effective relaxation rate R2, rather than directly regressing intensities. A first-order MAML meta-learning pipeline trains on simulated data with episodic real-data injection for domain adaptation.
Load-bearing premise
The physics-constrained signal model includes an unconstrained learnable residual term that is added to the physics-based intensity formula. This residual can in principle absorb any deviation from the idealized signal equation, meaning the network could learn to bypass the physics constraint entirely and regress target intensities through the residual, making the biophysical-plausibility guarantee depend on whether the network actually uses the physics pathway rather than a兜
What would settle it
On real 64 mT–3T paired data, the method achieves 26.85 dB PSNR and 0.8856 SSIM, outperforming all baselines (LIIF, LTE, Pixel-to-Gaussian) by over 6.5 dB in PSNR. On the FastMRI benchmark, it achieves 34.26 dB PSNR at 4× upscaling, exceeding the prior best method (MS-PRDDiff) by 1.45 dB. The non-monotonic resolution hypothesis is supported by non-monotonic PSNR/SSIM curves across input resolution scales on both simulated (best at ×0.7) and real (competitive at ×0.76) datasets.
If this is right
- If the non-monotonic resolution-SNR finding generalizes, MRI acquisition protocols could be redesigned to capture at an intermediate resolution that is cheaper and faster to acquire, rather than maximally resolved scans, trusting post-processing to recover the detail.
- The resolution-agnostic Gaussian Splatting representation could be extended to 3D volumetric MRI, where the SNR penalty for isotropic resolution doubling is a factor of 8 (64× more averages to recover), making the optimal-resolution argument even stronger.
- The physics-constrained intensity decomposition into proton density and relaxation parameters could enable the super-resolution model to output quantitative tissue parameter maps as a byproduct, not just enhanced images.
- If the intermediate-resolution optimum is confirmed across more pulse sequences and field strengths, scanner manufacturers could build acquisition protocols that intentionally target the SNR-optimal point rather than the finest nominal resolution.
Editorial analysis
A structured set of objections, weighed in public.
Referee Report
Summary. This paper proposes PhyMRI-SR, a physics-aware MRI super-resolution framework based on 2D Gaussian Splatting. The central thesis is that the optimal input resolution for MRI super-resolution is not necessarily the highest achievable resolution, due to the resolution-SNR trade-off inherent in MRI physics. The framework introduces three innovations: (1) a prior-aware Gaussian representation with anatomical structure-guided initialization and an MRI-specific covariance dictionary, (2) physics-constrained signal modeling that predicts proton density and relaxation parameters rather than directly regressing intensities, and (3) a meta-learning framework for domain adaptation from simulated to real data. Experiments are conducted on simulated IXI data, a real 3T-5T dynamic-resolution dataset, the FastMRI benchmark, and a real 64mT-3T paired dataset. The method reports state-of-the-art performance on FastMRI (34.26 dB PSNR at 4x) and substantial improvements on real 64mT-3T data (26.85 dB vs. <20.3 dB for baselines).
Significance. The paper addresses a clinically relevant problem and proposes a well-motivated framework. The resolution-SNR derivation (Eqs. 1-4, S17-S36) is standard but correctly applied and clearly presented. The adaptation of 2D Gaussian Splatting to MRI with domain-specific priors is a reasonable architectural choice for continuous-scale super-resolution. The FastMRI benchmark results (Table II) are strong, with a 1.45 dB PSNR improvement over the best diffusion-based baseline at 4x. The real 64mT-3T results (Table III) show a substantial 6.5+ dB improvement over baselines, which is noteworthy. The meta-learning domain adaptation strategy is a practical contribution for the paired-data scarcity problem. However, the significance of the central 'optimal resolution' claim is weakened by inconsistencies in the supporting evidence and by the unconstrained residual in the physics model.
major comments (4)
- §IV-B, Eq. (16): The physics-constrained signal model c_i = rho_i * e^{-R2,i} + delta_i includes an unconstrained learnable residual delta_i. Since delta_i can absorb any deviation from the idealized signal equation, the claim of 'biophysically plausible contrast' is at risk of being vacuous — the network can learn delta_i ≈ c_i - rho_i * e^{-R2,i} for any target intensity, reducing the physics constraint to a reparameterization of direct intensity regression. The ablation in Table V shows the physics module improves SSIM from 0.55 to 0.85, but without constraining or analyzing delta_i (e.g., reporting its magnitude relative to the physics term, or adding a regularization term), it is unclear whether the improvement comes from the physics constraint or from the reparameterization acting as a different optimization landscape. The authors should either constrain delta_i (e.g., norm-bounded
- §V-C.2 and Table I (Real Multi-Resolution Dataset): The headline claim that 'the optimal resolution for MRI super-resolution is not necessarily the highest achievable resolution' is contradicted by the paper's own real data. On the 3T-5T dataset, the highest input resolution (x1.04) achieves the best PSNR (26.78 dB) and tied-best SSIM (0.8775). The paper acknowledges this but reframes it by pointing to secondary metrics (HFEN best at x0.76, DISTS best at x0.83). However, the claim is stated in terms of overall quality, and the primary metrics favor the highest resolution on real data. On the simulated IXI data, the evidence is marginal: x0.7 gives PSNR 28.10 vs. 28.06 at x1.0, a 0.04 dB difference within typical run-to-run variance. The authors should either soften the headline claim to reflect that different quality metrics favor different resolutions, or provide statistical evidence (e
- §S2.11 (Eqs. S37-S41) and Table I: The degradation model for simulating low-field MRI uses task-dependent blur sigma and noise alpha parameters, but the paper does not specify how these parameters are calibrated to the resolution-SNR trade-off in Eq. (4) for each resolution scale. If the noise level at each resolution scale is not set proportional to voxel volume (as Eq. 4 dictates), the 'optimal' intermediate resolution observed on simulated data could be an artifact of the chosen sigma and alpha values rather than a fundamental physics property. The authors should explicitly state the sigma and alpha values used for each resolution scale in Table I and verify that they are consistent with the SNR scaling predicted by Eq. (4).
- Table VI: The ablation table for meta-learning labels the second variant 'w/o Physics' in the Method column, but the text describes it as 'w/o Meta' (a model without meta-learning). This appears to be a labeling error. If the variant truly removes meta-learning, the label should read 'w/o Meta'. If it removes physics, then the ablation does not test the meta-learning contribution. This needs correction and clarification.
minor comments (9)
- Abstract: 'futher' should be 'further' (appears twice in abstract and introduction).
- §IV-A: 'domian-specific' should be 'domain-specific'.
- §IV-A.2: The covariance dictionary is built from 4,241 5T MRI slices (§S3.A). The paper should clarify whether these slices overlap with the test set used in Table I (Real Multi-Resolution Dataset), and if so, whether this constitutes a form of train-test leakage. If the dictionary is built from training data only, this should be stated explicitly.
- §V-A: 'acquision' should be 'acquisition' (appears in Eq. 3 caption area).
- Table I: The simulated IXI dataset shows DISTS values of 0.1231 for both x1.0 and x0.9, which is suspicious. The authors should verify this is not a copy error.
- §V-C.2: The phrase 'the optimal resolution lies in an intermediate range rather than at the extreme ends' overstates the real-data evidence, where x1.04 is best or tied-best on two of four metrics. Consider softening this language.
- Figure 2 caption: 'segmentator' is non-standard terminology; consider 'segmentation network' or 'segmentation model' for consistency with standard terminology.
- §S3.C.3, Eq. (S42): The reference 'Method Section ??' is an unresolved LaTeX cross-reference.
- The paper would benefit from reporting standard deviations or confidence intervals for the dynamic-resolution experiments (Table I), especially given that the key PSNR differences on simulated data (28.10 vs. 28.06) are small.
Simulated Author's Rebuttal
We thank the referee for a careful and constructive review. The referee raises four major points: (1) the unconstrained residual delta_i in the physics-constrained signal model may render the physics constraint vacuous; (2) the headline claim that optimal resolution is not the highest is contradicted by the real 3T-5T data where the highest resolution achieves best PSNR; (3) the degradation model's sigma and alpha parameters may not be calibrated to the SNR scaling of Eq. (4), potentially making the simulated optimal-resolution finding an artifact; and (4) a labeling error in Table VI. We address each point below and describe the revisions we will make.
read point-by-point responses
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Referee: §IV-B, Eq. (16): The physics-constrained signal model c_i = rho_i * e^{-R2,i} + delta_i includes an unconstrained learnable residual delta_i. Since delta_i can absorb any deviation from the idealized signal equation, the claim of 'biophysically plausible contrast' is at risk of being vacuous. The ablation in Table V shows the physics module improves SSIM from 0.55 to 0.85, but without constraining or analyzing delta_i, it is unclear whether the improvement comes from the physics constraint or from the reparameterization acting as a different optimization landscape.
Authors: The referee raises a valid and important concern. We agree that without any constraint or analysis on delta_i, the physics-constrained formulation could in principle degenerate into a reparameterization of direct intensity regression, which would weaken our claim of biophysically plausible contrast. In the revised manuscript, we will make two changes. First, we will add an L2 regularization term on delta_i (lambda * ||delta||_2) to the training objective, penalizing large deviations from the physics-predicted signal and encouraging the network to rely on the physical model rather than absorbing all intensity information into the residual. Second, we will report the ratio ||delta_i|| / ||rho_i * e^{-R2,i}|| measured on the test set, demonstrating that the physics term dominates the residual and that delta_i accounts for a small fraction of the total intensity. This will directly address whether the improvement in SSIM (0.55 to 0.85) comes from the physics constraint rather than from reparameterization alone. We will also add an ablation variant with delta_i = 0 (fully constrained) to isolate the contribution of the physics term from the residual. We note that the qualitative results in Figure S8 already provide indirect evidence that the physics module restores correct grayscale fidelity consistent with the ground truth, which pure reparameterization would not necessarily achieve. However, we agree that quantitative analysis of delta_i is needed to substantiate this claim. revision: yes
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Referee: §V-C.2 and Table I: The headline claim that 'the optimal resolution for MRI super-resolution is not necessarily the highest achievable resolution' is contradicted by the paper's own real data. On the 3T-5T dataset, the highest input resolution (x1.04) achieves the best PSNR (26.78 dB) and tied-best SSIM (0.8775). The paper acknowledges this but reframes it by pointing to secondary metrics (HFEN best at x0.76, DISTS best at x0.83). On the simulated IXI data, the evidence is marginal: x0.7 gives PSNR 28.10 vs. 28.06 at x1.0, a 0.04 dB difference within typical run-to-run variance.
Authors: The referee is correct that the real 3T-5T data does not unambiguously support the headline claim when PSNR and SSIM are the primary metrics. On the real data, the highest resolution (x1.04) achieves the best PSNR (26.78 dB) and tied-best SSIM (0.8775), while intermediate resolutions are favored only by HFEN (x0.76) and DISTS (x0.83). On the simulated IXI data, the PSNR difference between x0.7 (28.10 dB) and x1.0 (28.06 dB) is indeed marginal at 0.04 dB. We will revise the manuscript in two ways. First, we will soften the headline claim from 'the optimal resolution for MRI super-resolution is not necessarily the highest achievable resolution' to a more precise statement: 'different quality metrics favor different resolution settings, and intermediate resolutions can achieve competitive or superior performance on perceptual and high-frequency metrics, suggesting that the highest input resolution is not universally optimal across all aspects of image quality.' Second, we will run multiple random seeds (at least 3) on the simulated IXI experiment and report mean and standard deviation for each resolution scale, so that the reader can assess whether the 0.04 dB difference is within run-to-run variance. If the difference is not statistically significant, we will state this explicitly and frame the simulated result as 'no significant degradation at intermediate resolution' rather than 'intermediate resolution is superior.' We acknowledge that the current evidence does not support a strong universal claim, and the revised framing will reflect this honestly. revision: yes
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Referee: §S2.11 (Eqs. S37-S41) and Table I: The degradation model for simulating low-field MRI uses task-dependent blur sigma and noise alpha parameters, but the paper does not specify how these parameters are calibrated to the resolution-SNR trade-off in Eq. (4) for each resolution scale. If the noise level at each resolution scale is not set proportional to voxel volume (as Eq. 4 dictates), the 'optimal' intermediate resolution observed on simulated data could be an artifact of the chosen sigma and alpha values rather than a fundamental physics property.
Authors: This is a fair concern. The referee is right that if the noise level alpha at each resolution scale is not set consistently with the SNR scaling predicted by Eq. (4) (i.e., SNR proportional to voxel volume), then the observed non-monotonic relationship between input resolution and SR performance on simulated data could be an artifact of the degradation parameter choices rather than a physics-driven phenomenon. In the revised manuscript, we will add a table specifying the exact sigma and alpha values used for each resolution scale in the simulated IXI experiment. We will also verify and explicitly state whether these values are calibrated to be proportional to voxel volume as dictated by Eq. (4). If the current values are not calibrated this way, we will re-run the simulated experiment with properly calibrated noise levels and update Table I accordingly. If the non-monotonic trend disappears under properly calibrated noise, we will report this honestly and revise our claims. We agree that this calibration is essential for the simulated-data evidence to be credible. revision: yes
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Referee: Table VI: The ablation table for meta-learning labels the second variant 'w/o Physics' in the Method column, but the text describes it as 'w/o Meta' (a model without meta-learning). This appears to be a labeling error. If the variant truly removes meta-learning, the label should read 'w/o Meta'. If it removes physics, then the ablation does not test the meta-learning contribution.
Authors: The referee is correct. This is a labeling error in Table VI. The text in the accompanying paragraph clearly describes the variant as 'a model without meta-learning (w/o Meta),' and the purpose of the ablation is to test the contribution of meta-learning. The label in the Method column should read 'w/o Meta,' not 'w/o Physics.' We will correct this in the revised manuscript. We apologize for the confusion. revision: yes
Circularity Check
No significant circularity found; one minor concern with covariance dictionary encoding target-domain statistics, but it is a learned prior, not a circular derivation.
full rationale
The paper's derivation chain does not exhibit circularity. The resolution-SNR trade-off (Eqs. 1–4, S17–S36) is standard MRI physics properly cited from external textbooks [33, 34, 73] and derived from the spin-echo signal equation without self-reference. The physics-constrained signal model (Eqs. 13–16) uses the well-known T2-weighted signal equation S ≈ ρ·e^{-R2}; the paper does not claim to derive this equation but adopts it as a known physical relationship. The unconstrained residual δ_i (Eq. 16) raises a correctness concern (it could absorb any deviation, making the physics constraint vacuous), but this is a validity issue, not circularity — the paper does not present δ_i as a prediction or first-principles result. The covariance dictionary (Section IV-A.2) is built by fitting 2D GS to 4,241 high-resolution 5T MRI slices and then constraining predicted covariances to linear combinations of dictionary entries. While this encodes target-domain spatial statistics into the model, it is presented as a learned prior (a dictionary), not as a prediction or derivation. The paper does not claim to 'predict' MRI system characteristics from first principles; it explicitly states the dictionary is constructed empirically from data. No self-citation chain is load-bearing: the 2D GS framework is cited from [39] (Pixel-to-Gaussian, external authors), meta-learning from MAML [74] (external), and segmentation from SynthSeg [95] (external). The 'optimal resolution' hypothesis is an empirical finding from experiments, not a derivation that reduces to its inputs. The minor score of 2 reflects the covariance dictionary's encoding of target-domain statistics, which could limit generalization claims, but this is a methodological design choice rather than a circular derivation.
Axiom & Free-Parameter Ledger
free parameters (6)
- Tissue complexity weights w_k (w_GM, w_WM, w_CSF) =
w_GM > w_WM > w_CSF (exact values not stated)
- Position offset scale δ =
Not specified
- Covariance dictionary size M =
1001
- Learnable residual δ_i =
Learned per-primitive
- Meta-learning inner-loop rate α =
Not specified
- Meta-learning outer-loop rate β =
Not specified
axioms (4)
- domain assumption MRI signal for T2-weighted spin echo simplifies to S ≈ ρ·e^{-TE/T2} when TR >> T1
- domain assumption Tissue properties ρ and R2 are resolution-invariant
- domain assumption The empirical covariance distribution from 5T MRI generalizes to other field strengths
- domain assumption Simulated degradation model (Eq. S37) accurately represents real low-field MRI
invented entities (1)
-
MRI-Specific Covariance Dictionary
no independent evidence
Cite this review
Pith. "Pith review of PhyMRI-SR: Toward Physics-Aware MRI Image Super-Resolution." pith.science (2026). https://pith.science/paper/OX5W2KRA
@misc{pith2026260706238,
author = {Pith},
title = {Pith review of: PhyMRI-SR: Toward Physics-Aware MRI Image Super-Resolution},
year = {2026},
howpublished = {\url{https://pith.science/paper/OX5W2KRA}},
note = {Machine review of arXiv:2607.06238}
}
read the original abstract
Magnetic resonance imaging (MRI) super-resolution is vital for improving diagnostic accessibility, yet most methods treat it as a deterministic mapping from a fixed low-resolution input to a high-resolution target. This overlooks a key property of MRI acquisition physics: spatial resolution and signal-to-noise ratio (SNR) are inherently coupled, making any given low-resolution scan merely one of many possible realizations under varying acquisition trade-offs. We rethink MRI super-resolution as a physics-aware reconstruction problem, in which the goal is to identify the optimal resolution-SNR configuration and then super-resolve it to obtain high-quality MRI results. A key implication of this formulation is that MRI resolution becomes dynamic rather than fixed. To handle such resolution-heterogeneous inputs, we adapt 2D Gaussian Splatting (2D GS) to MRI by formulating reconstruction as a coordinate-based, resolution-agnostic rendering problem. To further enhance fidelity, we introduce three innovations: (1) a prior-aware Gaussian representation that combines an Anatomical Structure Prior for tissue-specific kernel initialization with an Imaging System Prior that captures hardware characteristics via a covariance dictionary; (2) a physics-constrained signal modeling scheme that predicts intrinsic tissue parameters (proton density rho and effective relaxation rate R2) and synthesizes intensities through governing physical equations, ensuring biophysically plausible contrast; and (3) a meta-learning framework that alleviates paired-data scarcity by pretraining on simulated data and adapting to real-world conditions. Extensive experiments on dynamic-resolution datasets and standard benchmarks demonstrate that our method achieves state-of-the-art performance, highlighting its strong potential for clinical deployment.
Figures
Reference graph
Works this paper leans on
-
[1]
Magnetic resonance imaging of musculoskeletal tumors,
M. J. Kransdorf, “Magnetic resonance imaging of musculoskeletal tumors,”Orthopedics, vol. 17, no. 11, pp. 1003–1016, 1994
work page 1994
-
[2]
Noninvasive mri evaluation of cerebral blood flow in cerebrovascular disease,
J. A. Detre, D. C. Alsop, L. Vives, L. Maccotta, J. Teener, and E. Raps, “Noninvasive mri evaluation of cerebral blood flow in cerebrovascular disease,”Neurology, vol. 50, no. 3, pp. 633–641, 1998
work page 1998
-
[3]
J. Islam and Y . Zhang, “Brain mri analysis for alzheimer’s disease diag- nosis using an ensemble system of deep convolutional neural networks,” Brain informatics, vol. 5, no. 2, p. 2, 2018
work page 2018
-
[4]
Deep learning for accelerated and robust mri reconstruction,
R. Heckel, M. Jacob, A. Chaudhari, O. Perlman, and E. Shimron, “Deep learning for accelerated and robust mri reconstruction,”Magnetic Resonance Materials in Physics, Biology and Medicine, vol. 37, no. 3, pp. 335–368, 2024
work page 2024
-
[5]
A review on deep learning mri reconstruction without fully sampled k-space,
G. Zeng, Y . Guo, J. Zhan, Z. Wang, Z. Lai, X. Du, X. Qu, and D. Guo, “A review on deep learning mri reconstruction without fully sampled k-space,”BMC Medical Imaging, vol. 21, no. 1, p. 195, 2021
work page 2021
-
[6]
Super-resolution in magnetic resonance imaging: a review,
E. Van Reeth, I. W. Tham, C. H. Tan, and C. L. Poh, “Super-resolution in magnetic resonance imaging: a review,”Concepts in Magnetic Reso- nance Part A, vol. 40, no. 6, pp. 306–325, 2012
work page 2012
-
[7]
Super- resolution reconstruction of mr image with a novel residual learning network algorithm,
J. Shi, Q. Liu, C. Wang, Q. Zhang, S. Ying, and H. Xu, “Super- resolution reconstruction of mr image with a novel residual learning network algorithm,”Physics in Medicine & Biology, vol. 63, no. 8, p. 085011, 2018
work page 2018
-
[8]
Medical image super-resolution reconstruction algorithms based on deep learning: A survey,
D. Qiu, Y . Cheng, and X. Wang, “Medical image super-resolution reconstruction algorithms based on deep learning: A survey,”Computer Methods and Programs in Biomedicine, vol. 238, p. 107590, 2023
work page 2023
-
[9]
Brain mri image super-resolution reconstruction: a systematic review,
A. Muhammad, S. Aramvith, K. Duangchaemkarn, and M.-T. Sun, “Brain mri image super-resolution reconstruction: a systematic review,” IEEE Access, vol. 12, pp. 156 347–156 362, 2024
work page 2024
-
[10]
A. C. Yang, M. Kretzler, S. Sudarski, V . Gulani, and N. Seiberlich, “Sparse reconstruction techniques in magnetic resonance imaging: meth- ods, applications, and challenges to clinical adoption,”Investigative radiology, vol. 51, no. 6, pp. 349–364, 2016
work page 2016
-
[11]
E. Plenge, D. H. Poot, M. Bernsen, G. Kotek, G. Houston, P. Wielopol- ski, L. Van Der Weerd, W. J. Niessen, and E. Meijering, “Super- resolution methods in mri: can they improve the trade-off between reso- lution, signal-to-noise ratio, and acquisition time?”Magnetic resonance in medicine, vol. 68, no. 6, pp. 1983–1993, 2012
work page 1983
-
[12]
Measuring information gain for frequency-encoded super-resolution mri,
G. S. Mayer and E. R. Vrscay, “Measuring information gain for frequency-encoded super-resolution mri,”Magnetic resonance imaging, vol. 25, no. 7, pp. 1058–1069, 2007
work page 2007
-
[13]
Q. M. Tieng, G. J. Cowin, D. C. Reutens, G. J. Galloway, and V . Vegh, “Mri resolution enhancement: How useful are shifted images obtained by changing the demodulation frequency?”Magnetic resonance in medicine, vol. 65, no. 3, pp. 664–672, 2011
work page 2011
-
[14]
Fast single image super-resolution using estimated low-frequency k-space data in mri,
J. Luo, Z. Mou, B. Qin, W. Li, F. Yang, M. Robini, and Y . Zhu, “Fast single image super-resolution using estimated low-frequency k-space data in mri,”Magnetic resonance imaging, vol. 40, pp. 1–11, 2017
work page 2017
-
[15]
Mri superresolution using self-similarity and image priors,
J. V . Manj ´on, P. Coup´e, A. Buades, D. L. Collins, and M. Robles, “Mri superresolution using self-similarity and image priors,”International journal of biomedical imaging, vol. 2010, no. 1, p. 425891, 2010
work page 2010
-
[16]
Resolution enhancement in mri,
E. Carmi, S. Liu, N. Alon, A. Fiat, and D. Fiat, “Resolution enhancement in mri,”Magnetic resonance imaging, vol. 24, no. 2, pp. 133–154, 2006
work page 2006
-
[17]
Mri inter-slice recon- struction using super-resolution,
H. Greenspan, G. Oz, N. Kiryati, and S. Peled, “Mri inter-slice recon- struction using super-resolution,”Magnetic resonance imaging, vol. 20, no. 5, pp. 437–446, 2002
work page 2002
-
[18]
Example-based super- resolution,
W. T. Freeman, T. R. Jones, and E. C. Pasztor, “Example-based super- resolution,”IEEE Computer graphics and Applications, vol. 22, no. 2, pp. 56–65, 2002
work page 2002
-
[19]
Multiscale brain mri super-resolution using deep 3d convolutional networks,
C.-H. Pham, C. Tor-D ´ıez, H. Meunier, N. Bednarek, R. Fablet, N. Passat, and F. Rousseau, “Multiscale brain mri super-resolution using deep 3d convolutional networks,”Computerized Medical Imaging and Graphics, vol. 77, p. 101647, 2019
work page 2019
-
[20]
Super-resolution of brain tumor mri images based on deep learning,
Z. Zhou, A. Ma, Q. Feng, R. Wang, L. Cheng, X. Chen, X. Yang, K. Liao, Y . Miao, and Y . Qiu, “Super-resolution of brain tumor mri images based on deep learning,”Journal of applied clinical medical physics, vol. 23, no. 11, p. e13758, 2022
work page 2022
-
[21]
Residual dense network for medical magnetic resonance images super-resolution,
D. Zhu and D. Qiu, “Residual dense network for medical magnetic resonance images super-resolution,”Computer Methods and Programs in Biomedicine, vol. 209, p. 106330, 2021
work page 2021
-
[22]
Spatio-angular convolutions for super-resolution in diffusion mri,
M. Lyon, P. Armitage, and M. A. ´Alvarez, “Spatio-angular convolutions for super-resolution in diffusion mri,”Advances in Neural Information Processing Systems, vol. 36, pp. 12 457–12 475, 2023
work page 2023
-
[23]
J. Lyu, G. Li, C. Wang, Q. Cai, Q. Dou, D. Zhang, and J. Qin, “Mul- ticontrast mri super-resolution via transformer-empowered multiscale contextual matching and aggregation,”IEEE Transactions on Neural Networks and Learning Systems, vol. 35, no. 9, pp. 12 004–12 014, 2023
work page 2023
-
[24]
Accurate multi-contrast mri super-resolution via a dual cross-attention transformer network,
S. Huang, J. Li, L. Mei, T. Zhang, Z. Chen, Y . Dong, L. Dong, S. Liu, and M. Lyu, “Accurate multi-contrast mri super-resolution via a dual cross-attention transformer network,” inInternational Conference on Medical Image Computing and Computer-Assisted Intervention. Springer, 2023, pp. 313–322
work page 2023
-
[25]
G. Li, L. Zhao, J. Sun, Z. Lan, Z. Zhang, J. Chen, Z. Lin, H. Lin, and W. Xing, “Rethinking multi-contrast mri super-resolution: Rectangle- window cross-attention transformer and arbitrary-scale upsampling,” in Proceedings of the IEEE/CVF international conference on computer vision, 2023, pp. 21 230–21 240
work page 2023
-
[28]
Inversesr: 3d brain mri super-resolution using a latent diffusion model,
J. Wang, J. Levman, W. H. L. Pinaya, P.-D. Tudosiu, M. J. Cardoso, and R. Marinescu, “Inversesr: 3d brain mri super-resolution using a latent diffusion model,” inInternational conference on medical image computing and computer-assisted intervention. Springer, 2023, pp. 438–447
work page 2023
-
[29]
M. Safari, S. Wang, Z. Eidex, Q. Li, R. L. Qiu, E. H. Middlebrooks, D. S. Yu, and X. Yang, “Mri super-resolution reconstruction using efficient diffusion probabilistic model with residual shifting,”Physics in Medicine & Biology, vol. 70, no. 12, p. 125008, 2025
work page 2025
-
[30]
Super- resolution musculoskeletal mri using deep learning,
A. S. Chaudhari, Z. Fang, F. Kogan, J. Wood, K. J. Stevens, E. K. Gibbons, J. H. Lee, G. E. Gold, and B. A. Hargreaves, “Super- resolution musculoskeletal mri using deep learning,”Magnetic reso- nance in medicine, vol. 80, no. 5, pp. 2139–2154, 2018
work page 2018
-
[31]
Brain mri super resolution using 3d deep densely connected neural networks,
Y . Chen, Y . Xie, Z. Zhou, F. Shi, A. G. Christodoulou, and D. Li, “Brain mri super resolution using 3d deep densely connected neural networks,” in2018 IEEE 15th international symposium on biomedical imaging (ISBI 2018). IEEE, 2018, pp. 739–742
work page 2018
-
[32]
Multi-contrast super-resolution mri through a progressive network,
Q. Lyu, H. Shan, C. Steber, C. Helis, C. Whitlow, M. Chan, and G. Wang, “Multi-contrast super-resolution mri through a progressive network,”IEEE transactions on medical imaging, vol. 39, no. 9, pp. 2738–2749, 2020
work page 2020
-
[33]
D. B. Plewes and W. Kucharczyk, “Physics of mri: a primer,”Journal of magnetic resonance imaging, vol. 35, no. 5, pp. 1038–1054, 2012
work page 2012
-
[34]
Understanding mri: basic mr physics for physicians,
S. Currie, N. Hoggard, I. J. Craven, M. Hadjivassiliou, and I. D. Wilkin- son, “Understanding mri: basic mr physics for physicians,”Postgraduate medical journal, vol. 89, no. 1050, pp. 209–223, 2013
work page 2013
-
[35]
Information content of snr/resolution trade-offs in three-dimensional magnetic resonance imaging,
S. Portnoy, S. Kale, A. Feintuch, C. Tardif, G. Pike, and R. Henkelman, “Information content of snr/resolution trade-offs in three-dimensional magnetic resonance imaging,”Medical physics, vol. 36, no. 4, pp. 1442– 1451, 2009
work page 2009
-
[36]
Rethinking dif- fusion model for multi-contrast mri super-resolution,
G. Li, C. Rao, J. Mo, Z. Zhang, W. Xing, and L. Zhao, “Rethinking dif- fusion model for multi-contrast mri super-resolution,” inProceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), 2024, pp. 11 365–11 374
work page 2024
-
[37]
B. M. Li, L. V . Castorina, M. d. C. Vald ´es Hern ´andez, U. Clancy, S. J. Wiseman, E. Sakka, A. J. Storkey, D. Jaime Garcia, Y . Cheng, F. Doubal et al., “Deep attention super-resolution of brain magnetic resonance images acquired under clinical protocols,”Frontiers in Computational Neuroscience, vol. 16, p. 887633, 2022
work page 2022
-
[38]
Smore: a self-supervised anti-aliasing and super-resolution algorithm for mri using deep learning,
C. Zhao, B. E. Dewey, D. L. Pham, P. A. Calabresi, D. S. Reich, and J. L. Prince, “Smore: a self-supervised anti-aliasing and super-resolution algorithm for mri using deep learning,”IEEE transactions on medical imaging, vol. 40, no. 3, pp. 805–817, 2020
work page 2020
-
[39]
Pixel to Gaussian: Ultra-Fast Continuous Super-Resolution with 2D Gaussian Modeling
L. Peng, A. Wu, W. Li, P. Xia, X. Dai, X. Zhang, X. Di, H. Sun, R. Pei, Y . Wanget al., “Pixel to gaussian: Ultra-fast continuous super-resolution with 2d gaussian modeling,”arXiv preprint arXiv:2503.06617, 2025
work page internal anchor Pith review Pith/arXiv arXiv 2025
-
[40]
arXiv preprint arXiv:2511.16854 (2025)
M. Khateri, S. Vasylechko, M. Ghahremani, L. Timms, D. Ko- canaogullari, S. K. Warfield, C. Jaimes, D. Karimi, A. Sierra, J. Tohka et al., “Mri super-resolution with deep learning: A comprehensive survey,”arXiv preprint arXiv:2511.16854, 2025
-
[41]
Application of tikhonov regularization to super-resolution reconstruction of brain mri images,
X. Zhang, E. Y . Lam, E. X. Wu, and K. K. Wong, “Application of tikhonov regularization to super-resolution reconstruction of brain mri images,” inMedical Imaging and Informatics: 2nd International Conference, MIMI 2007, Beijing, China, August 14–16, 2007, Revised Selected Papers. Springer, 2008, pp. 51–56
work page 2007
-
[42]
A Tool for Super-Resolving Multimodal Clinical MRI
M. Brudfors, Y . Balbastre, P. Nachev, and J. Ashburner, “A tool for super-resolving multimodal clinical mri,”arXiv preprint arXiv:1909.01140, 2019. JOURNAL OF LATEX CLASS FILES, VOL. 14, NO. 8, AUGUST 2021 13
work page internal anchor Pith review Pith/arXiv arXiv 1909
-
[43]
Nonlinear total variation based noise removal algorithms,
L. I. Rudin, S. Osher, and E. Fatemi, “Nonlinear total variation based noise removal algorithms,”Physica D: Nonlinear Phenomena, vol. 60, no. 1–4, pp. 259–268, 1992
work page 1992
-
[44]
S. Tourbier, X. Bresson, P. Hagmann, J.-P. Thiran, R. Meuli, and M. B. Cuadra, “An efficient total variation algorithm for super-resolution in fetal brain mri with adaptive regularization,”NeuroImage, vol. 118, pp. 584–597, 2015
work page 2015
-
[45]
Lrtv: Mr image super-resolution with low-rank and total variation regularizations,
F. Shi, J. Cheng, L. Wang, P.-T. Yap, and D. Shen, “Lrtv: Mr image super-resolution with low-rank and total variation regularizations,”IEEE Transactions on Medical Imaging, vol. 34, no. 12, pp. 2459–2466, 2015
work page 2015
-
[46]
Super-resolution from a single image,
D. Glasner, S. Bagon, and M. Irani, “Super-resolution from a single image,” in2009 IEEE 12th International Conference on Computer Vision. IEEE, 2009, pp. 349–356
work page 2009
-
[47]
Isotropic reconstruction of mr images using 3d patch-based self-similarity learning,
A. Bustin, D. V oilliot, A. Menini, J. Felblinger, C. de Chillou, D. Burschka, L. Bonnemains, and F. Odille, “Isotropic reconstruction of mr images using 3d patch-based self-similarity learning,”IEEE Transactions on Medical Imaging, vol. 37, no. 8, pp. 1932–1942, 2018
work page 1932
-
[48]
Deep mr brain image super-resolution using spatio-structural priors,
V . Cherukuri, T. Guo, S. J. Schiff, and V . Monga, “Deep mr brain image super-resolution using spatio-structural priors,”IEEE Transactions on Image Processing, vol. 29, pp. 1368–1383, 2019
work page 2019
-
[49]
P. Li, J. Chen, D. Nan, J. Zou, D. Lin, and Y . Hu, “Motion-aligned 4dmri reconstruction using higher degree total variation and locally low-rank regularization,”Magnetic Resonance Imaging, vol. 93, pp. 97–107, 2022
work page 2022
-
[50]
Accelerated mri reconstruction with separable and enhanced low-rank hankel regularization,
X. Zhang, H. Lu, D. Guo, Z. Lai, H. Ye, X. Peng, B. Zhao, and X. Qu, “Accelerated mri reconstruction with separable and enhanced low-rank hankel regularization,”IEEE Transactions on Medical Imaging, vol. 41, no. 9, pp. 2486–2498, 2022
work page 2022
-
[51]
Image super-resolution based on structure-modulated sparse representation,
Y . Zhang, J. Liu, W. Yang, and Z. Guo, “Image super-resolution based on structure-modulated sparse representation,”IEEE Transactions on Image Processing, vol. 24, no. 9, pp. 2797–2810, 2015
work page 2015
-
[52]
Sparse representation-based mri super-resolution reconstruction,
Y .-H. Wang, J. Qiao, J.-B. Li, P. Fu, S.-C. Chu, and J. F. Roddick, “Sparse representation-based mri super-resolution reconstruction,”Mea- surement, vol. 47, pp. 946–953, 2014
work page 2014
-
[53]
Y . Zhang, G. Wu, P.-T. Yap, Q. Feng, J. Lian, W. Chen, and D. Shen, “Hierarchical patch-based sparse representation—a new approach for resolution enhancement of 4d-ct lung data,”IEEE Transactions on Medical Imaging, vol. 31, no. 11, pp. 1993–2005, 2012
work page 1993
-
[54]
Generalizing the nonlocal-means to super-resolution reconstruction,
M. Protter, M. Elad, H. Takeda, and P. Milanfar, “Generalizing the nonlocal-means to super-resolution reconstruction,”IEEE Transactions on Image Processing, vol. 18, no. 1, pp. 36–51, 2008
work page 2008
-
[55]
J. V . Manj´on, P. Coup´e, A. Buades, V . Fonov, D. L. Collins, and M. Rob- les, “Non-local mri upsampling,”Medical Image Analysis, vol. 14, no. 6, pp. 784–792, 2010
work page 2010
-
[56]
Mri upsampling using feature-based nonlocal means approach,
K. Jafari-Khouzani, “Mri upsampling using feature-based nonlocal means approach,”IEEE Transactions on Medical Imaging, vol. 33, no. 10, pp. 1969–1985, 2014
work page 1969
-
[57]
Fast and robust multiframe super resolution,
S. Farsiu, M. D. Robinson, M. Elad, and P. Milanfar, “Fast and robust multiframe super resolution,”IEEE Transactions on Image Processing, vol. 13, no. 10, pp. 1327–1344, 2004
work page 2004
-
[58]
Isotropic mri super-resolution reconstruction with multi-scale gradient field prior,
Y . Sui, O. Afacan, A. Gholipour, and S. K. Warfield, “Isotropic mri super-resolution reconstruction with multi-scale gradient field prior,” in International Conference on Medical Image Computing and Computer- Assisted Intervention. Springer, 2019, pp. 3–11
work page 2019
-
[59]
Learning a gradient guidance for spatially isotropic mri super- resolution reconstruction,
——, “Learning a gradient guidance for spatially isotropic mri super- resolution reconstruction,” inInternational Conference on Medical Im- age Computing and Computer-Assisted Intervention. Springer, 2020, pp. 136–146
work page 2020
-
[60]
Photo-realistic single image super-resolution using a generative adversarial network,
C. Ledig, L. Theis, F. Huszar, J. Caballeroet al., “Photo-realistic single image super-resolution using a generative adversarial network,” inProceedings of the IEEE Conference on Computer Vision and Pattern Recognition (CVPR), 2017, pp. 4681–4690
work page 2017
-
[61]
Enhanced generative adversarial network for 3d brain mri super-resolution,
J. Wang, Y . Chen, Y . Wu, J. Shi, and J. Gee, “Enhanced generative adversarial network for 3d brain mri super-resolution,” inProceedings of the IEEE/CVF Winter Conference on Applications of Computer Vision (WACV), 2020, pp. 3627–3636
work page 2020
-
[62]
Soup-gan: Super-resolution mri using generative adversarial networks,
K. Zhang, H. Hu, K. Philbrick, G. M. Conte, J. D. Sobek, P. Rouzrokh, and B. J. Erickson, “Soup-gan: Super-resolution mri using generative adversarial networks,”Tomography, vol. 8, no. 2, pp. 905–919, 2022
work page 2022
-
[63]
Disgan: Wavelet-informed discriminator guides gan to mri super-resolution with noise cleaning,
Q. Wang, L. Mahler, J. Steiglechner, F. Birk, K. Scheffler, and G. Lohmann, “Disgan: Wavelet-informed discriminator guides gan to mri super-resolution with noise cleaning,” inProceedings of the IEEE/CVF International Conference on Computer Vision (ICCV), 2023, pp. 2452–2461
work page 2023
-
[64]
Q. Zhang, Y . Hang, F. Wu, S. Wang, and Y . Hong, “Super-resolution of 3d medical images by generative adversarial networks with long and short-term memory and attention,”Scientific Reports, vol. 15, no. 1, p. 20828, 2025
work page 2025
-
[65]
Nesvor: Implicit neural representation for slice-to- volume reconstruction in mri,
J. Xu, D. Moyer, B. Gagoski, J. E. Iglesias, P. E. Grant, P. Golland, and E. Adalsteinsson, “Nesvor: Implicit neural representation for slice-to- volume reconstruction in mri,”IEEE Transactions on Medical Imaging, vol. 42, no. 6, pp. 1707–1719, 2023
work page 2023
-
[66]
W. Fang, Y . Tang, H. Guo, M. Yuan, T. C. Mok, K. Yan, J. Yao, X. Chen, Z. Liu, L. Luet al., “Cycleinr: Cycle implicit neural representation for arbitrary-scale volumetric super-resolution of medical data,” in Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), 2024, pp. 11 631–11 641
work page 2024
-
[67]
Gaussiansr: High fidelity 2d gaussian splatting for arbitrary-scale image super-resolution,
J. Hu, B. Xia, B. Chen, W. Yang, and L. Zhang, “Gaussiansr: High fidelity 2d gaussian splatting for arbitrary-scale image super-resolution,” inProceedings of the AAAI Conference on Artificial Intelligence, vol. 39, 2025, pp. 3554–3562
work page 2025
-
[68]
Meta-sr: A magnification-arbitrary network for super-resolution,
X. Hu, H. Mu, X. Zhang, Z. Wang, T. Tan, and J. Sun, “Meta-sr: A magnification-arbitrary network for super-resolution,” inProceedings of the IEEE Conference on Computer Vision and Pattern Recognition (CVPR), 2019, pp. 1575–1584
work page 2019
-
[69]
Learning continuous image representa- tion with local implicit image function,
Y . Chen, S. Liu, and X. Wang, “Learning continuous image representa- tion with local implicit image function,” inProceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), 2021
work page 2021
-
[70]
Local texture estimator for implicit representation func- tion,
Y . Xuet al., “Local texture estimator for implicit representation func- tion,” inProceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), 2022
work page 2022
-
[71]
J. Cao, Q. Wang, Y . Xian, Y . Li, B. Ni, Z. Pi, K. Zhang, Y . Zhang, R. Timofte, and L. Van Gool, “Ciaosr: Continuous implicit attention- inattention network for arbitrary-scale image super-resolution,” inPro- ceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), 2023, pp. 1796–1807
work page 2023
-
[72]
Spin echo magnetic resonance imaging,
B. A. Jung and M. Weigel, “Spin echo magnetic resonance imaging,” Journal of Magnetic Resonance Imaging, vol. 37, no. 4, pp. 805–817, 2013
work page 2013
-
[73]
R. W. Brown, Y .-C. N. Cheng, E. M. Haacke, M. R. Thompson, and R. Venkatesan,Magnetic resonance imaging: physical principles and sequence design. John Wiley & Sons, 2014
work page 2014
-
[74]
On First-Order Meta-Learning Algorithms
A. Nichol, J. Achiam, and J. Schulman, “On first-order meta-learning algorithms,”arXiv preprint arXiv:1803.02999, 2018
work page internal anchor Pith review Pith/arXiv arXiv 2018
-
[75]
Information eXtraction from Images (IXI) Consortium, “Ixi dataset,” https://brain-development.org/ixi-dataset/, accessed: 2026
work page 2026
-
[76]
J. Wang, Z. Shi, X. Gu, Y . Yang, and J. Sun, “Diffusion-based arbitrary- scale magnetic resonance image super-resolution via progressive k-space reconstruction and denoising,”Medical Image Analysis, p. 103814, 2025
work page 2025
-
[77]
Paired 64mt and 3t brain mri scans of healthy subjects for neuroimaging research,
R. van den Broek, B. Lena, and A. Webb, “Paired 64mt and 3t brain mri scans of healthy subjects for neuroimaging research,” May 2024. [Online]. Available: https://doi.org/10.5281/zenodo.15862148
-
[78]
Swinir: Image restoration using swin transformer,
J. Liang, J. Cao, G. Sun, K. Zhang, L. Van Gool, and R. Timofte, “Swinir: Image restoration using swin transformer,” inProceedings of the IEEE/CVF International Conference on Computer Vision Workshops (ICCVW), 2021, pp. 1833–1844
work page 2021
-
[79]
U-net: Convolutional networks for biomedical image segmentation,
O. Ronneberger, P. Fischer, and T. Brox, “U-net: Convolutional networks for biomedical image segmentation,” inInternational Conference on Medical image computing and computer-assisted intervention. Springer, 2015, pp. 234–241
work page 2015
-
[80]
Adam: A Method for Stochastic Optimization
D. P. Kingma and J. Ba, “Adam: A method for stochastic optimization,” arXiv preprint arXiv:1412.6980, 2014
work page internal anchor Pith review Pith/arXiv arXiv 2014
-
[81]
W. Chen, S. Wu, S. Wang, Z. Li, J. Yang, H. Yao, Q. Tian, and X. Song, “Multicontrast image super-resolution with deformable atten- tion and neighborhood-based feature aggregation (dance): Applications in anatomic and metabolic mri,”Medical Image Analysis, vol. 99, p. 103359, 2025
work page 2025
-
[82]
G. Li, J. Lyu, C. Wang, Q. Dou, and J. Qin, “Wavtrans: Synergizing wavelet and cross-attention transformer for multi-contrast mri super- resolution,” inInternational Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI), 2022, pp. 463–473
work page 2022
This paper was first reviewed by glm-5.2 on July 8, 2026.
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